ID   A0A1V2LDA4_CYBFA        Unreviewed;      1502 AA.
AC   A0A1V2LDA4;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 31.
DE   SubName: Full=Vacuolar protein sorting/targeting protein 10 {ECO:0000313|EMBL:ONH69366.1};
GN   ORFNames=BON22_0555 {ECO:0000313|EMBL:ONH69366.1};
OS   Cyberlindnera fabianii (Yeast) (Hansenula fabianii).
OC   Eukaryota; Fungi; Dikarya; Ascomycota; Saccharomycotina; Saccharomycetes;
OC   Saccharomycetales; Phaffomycetaceae; Cyberlindnera.
OX   NCBI_TaxID=36022 {ECO:0000313|EMBL:ONH69366.1, ECO:0000313|Proteomes:UP000189513};
RN   [1] {ECO:0000313|Proteomes:UP000189513}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=65 {ECO:0000313|Proteomes:UP000189513};
RX   PubMed=28385833; DOI=10.1128/genomeA.00064-17;
RA   van Rijswijck I.M.H., Derks M.F.L., Abee T., de Ridder D., Smid E.J.;
RT   "Genome sequences of Cyberlindnera fabianii 65, Pichia kudriavzevii 129,
RT   and Saccharomyces cerevisiae 131 isolated from fermented masau fruits in
RT   Zimbabwe.";
RL   Genome Announc. 5:E00064-E00064(2017).
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ONH69366.1}.
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DR   EMBL; MPUK01000001; ONH69366.1; -; Genomic_DNA.
DR   STRING; 36022.A0A1V2LDA4; -.
DR   VEuPathDB; FungiDB:BON22_0555; -.
DR   OMA; KANDGTC; -.
DR   OrthoDB; 5840at2759; -.
DR   Proteomes; UP000189513; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   GO; GO:0007034; P:vacuolar transport; IEA:UniProt.
DR   CDD; cd15482; Sialidase_non-viral; 1.
DR   Gene3D; 2.10.70.80; -; 2.
DR   Gene3D; 3.30.60.270; -; 2.
DR   Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 2.
DR   InterPro; IPR031777; Sortilin_C.
DR   InterPro; IPR031778; Sortilin_N.
DR   InterPro; IPR006581; VPS10.
DR   InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR   PANTHER; PTHR12106; SORTILIN RELATED; 1.
DR   PANTHER; PTHR12106:SF27; VPS10 HOMOLOG 1-RELATED; 1.
DR   Pfam; PF15902; Sortilin-Vps10; 2.
DR   Pfam; PF15901; Sortilin_C; 2.
DR   SMART; SM00602; VPS10; 2.
DR   SUPFAM; SSF110296; Oligoxyloglucan reducing end-specific cellobiohydrolase; 2.
PE   4: Predicted;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189513};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737}; Signal {ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..21
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           22..1502
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5012369532"
FT   TRANSMEM        1345..1366
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          44..668
FT                   /note="VPS10"
FT                   /evidence="ECO:0000259|SMART:SM00602"
FT   DOMAIN          700..1332
FT                   /note="VPS10"
FT                   /evidence="ECO:0000259|SMART:SM00602"
FT   REGION          1478..1502
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   1502 AA;  168226 MW;  59CF477FA5DAB4CC CRC64;
     MRSPTSACLI LLWCLSVAVS AFSPEVHRTE FNKLSKSLLY FDDAPVVFDL NDGNLLISED
     SGKNWEKSLD NIDRIHIDTV KKERAFAFTT GSTHYVTNNR GKSWKEFNVP IDKDLTYEVN
     VNYANPDQIL LALLTCDEDT GKCNSDIYYT TDGFNTDPKI MMEKTVKCLF AKSTPVFETH
     DDSRIICLKT ELDKFGYLQR SRLLTSTDFF KTTPDIINDN TDDLANGYVY DLQVIQTFVV
     AVVQSDRYDT DSGPVMLYVS KDGRNFNKAI LSEKLIAHGF EFLESTKHSL HISVWGYANS
     MGLSSVLASD TDGLHYRNLL SNVETDAVGF INMDKVENVE GVWIAAVANG FDQTSLEPLV
     RSKITFDDGR TWSFMRTEDC PGDVACSLNL LSIEERRGDG QSASGPTPGL LLGVGNTGVR
     LNNDVTKMHT YFSRDGGYSW KKVLDEPTIF SFGDFGNVIV AAPYSKKGDT RQLLTKKLYY
     SLDQAETWET IELEEELFPF MLTTAIDGSM TQFLFGGLVG DSLSVQNQIL YSLDFSRAFD
     KSCADDDFER WFGRSHGEGD GACLFGHKDI YQRRKADAKC FINKAWVDLK LEEVPCECTI
     ADYECNSGLY MNSKGECVPD RAYFARLCSS SPATSYEYLD RKKIPGNMCT GGDVQINEFI
     YDCTQDAAKT RDILTSEFSI PGKITRYLFL EQSEYHKSDE TVLVLNNLNQ LFISHDGGEK
     FHQFATDEEI IDVYLNPYFT DVAYLVTANK KLYVSADRAA TFVMSQAPSE VNHFGFPALQ
     FTNSSAEISV FFGQEGCEDA WSKDCRPVAY LSEDFGLHWQ LLLRDAVKCD YAGARSIQSD
     ANPETIICQV HKDQKYSLVS SSDKFATSQT EFENIVGFAT TGHFTVIAAR EGDSLKAYVT
     GDGKEFAAAE FPKNFVVNHQ QAYTVLGAES GAIFFHVTTN DRAGSEFGAI LKSNANGTSY
     VLSQSQVNRD ERGFVDYEKV EGLEGIAIIN TVSNHQEARQ GAMKQLQSKI TFNDGSDWDL
     IQPPSTDSDG NVYPCFGKSL KECSLHLHGY TERKDVRDTF SSGSATGLLL ARGNVGDKLG
     PLRDAATFLT SDGGSTWKEV KKGSYQWEFG DRGSIIALVN DEENTNTLTY SLDEGNTWQD
     YKFTNDTVKI ADIVTVPSDT SKKFLLITRS EASRGDESRT FTINFEKVFS RQCVLDLEYP
     DSDDFEYWSP KHPFESSNCL FGHEAKYLRK LPNRIDCFIG SAPLSAGFKI ERDCPCTRRD
     FECDYNYAKA EDGTCKLVNG LQPEDRSEIC RIDKNAVEYF EPTGYRKIPM STCKGGQEFD
     KWNPVPCPGK EDEFQERHGG KLKGLGLAMV IVIPILVFIG ATWFVYIKGI RRNGGFARFG
     EIRLGEEDDL IENNVTDKVV NHIVRGGITV IAAVIATYKV IRMMDSAVIE RVKGIFRRGN
     RYTARGDGFR AVGEADYRDE DDILDDVLND EDYEIDDETD LLPEADAGDD RLNNADNAEE
     EV
//