ID   A0A1V2M542_9FIRM        Unreviewed;      1026 AA.
AC   A0A1V2M542;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 23.
DE   RecName: Full=Penicillin-binding protein {ECO:0008006|Google:ProtNLM};
GN   ORFNames=AN641_01385 {ECO:0000313|EMBL:ONI43302.1};
OS   Epulopiscium sp. SCG-C07WGA-EpuloA2.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Candidatus Epulonipiscium.
OX   NCBI_TaxID=1712378 {ECO:0000313|EMBL:ONI43302.1, ECO:0000313|Proteomes:UP000189533};
RN   [1] {ECO:0000313|Proteomes:UP000189533}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Ngugi D.K., Miyake S., Stingl U.;
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004167}; Single-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004167}.
CC   -!- SIMILARITY: Belongs to the transpeptidase family.
CC       {ECO:0000256|ARBA:ARBA00007171}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ONI43302.1}.
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DR   EMBL; LJHE01000089; ONI43302.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V2M542; -.
DR   STRING; 1712378.AN641_01385; -.
DR   Proteomes; UP000189533; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0008658; F:penicillin binding; IEA:InterPro.
DR   Gene3D; 3.40.710.10; DD-peptidase/beta-lactamase superfamily; 2.
DR   Gene3D; 3.90.1310.10; Penicillin-binding protein 2a (Domain 2); 2.
DR   InterPro; IPR012338; Beta-lactam/transpept-like.
DR   InterPro; IPR005311; PBP_dimer.
DR   InterPro; IPR036138; PBP_dimer_sf.
DR   InterPro; IPR001460; PCN-bd_Tpept.
DR   PANTHER; PTHR30627; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE; 1.
DR   PANTHER; PTHR30627:SF2; PEPTIDOGLYCAN D,D-TRANSPEPTIDASE MRDA; 1.
DR   Pfam; PF03717; PBP_dimer; 2.
DR   Pfam; PF00905; Transpeptidase; 2.
DR   SUPFAM; SSF56601; beta-lactamase/transpeptidase-like; 2.
DR   SUPFAM; SSF56519; Penicillin binding protein dimerisation domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189533}.
FT   DOMAIN          41..93
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          118..286
FT                   /note="Penicillin-binding protein dimerisation"
FT                   /evidence="ECO:0000259|Pfam:PF03717"
FT   DOMAIN          462..640
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
FT   DOMAIN          852..1007
FT                   /note="Penicillin-binding protein transpeptidase"
FT                   /evidence="ECO:0000259|Pfam:PF00905"
SQ   SEQUENCE   1026 AA;  116068 MW;  536015D8C2D07BC6 CRC64;
     MMGGIIFLFS IILLRFYELQ IIEHSNYINK VQSGVERIVD VEATRGLIYD RYGRILASNE
     PIHVVKIDLQ VKQSEKELNN VILDLLQIFK KNGDIFIDTM PISKDAPFSY TASESTLNRF
     MYSIPYNSEE QRQELLKKSA QEIIEYLRAQ YDISDYISDR EARDIIAIRN IMYPYSYRQY
     KLPTIASDIS ELSATYIKEN YDKYPGVIVE FDSKRVYEYG EIIGNIIGYT RTMTDSLYKD
     LKDKGYDEND IVGHEGIEKS MEEILRGQKG TSLIEVDTLG RKVNTISEST AIKGNDIFLT
     IDIDLQQQVF DSIEKRLSEA LIVRLKGSKI GTKAITAREM LISMIECSQL LVNDMEYASE
     DSMSKHIYTQ LFNEYETLNH LVKEELTLQD LLLQWITAKE SPLTDKEIIL AMHEQGSLFL
     TEKEIENIYH NIEGDGKYIL ISQLEKGYLK PSQMAIDPFS AAATVVDVNT GEVLAMVGYP
     SVNSEALTSD FNNYYSTLFD NRSMLWNRSI MTVKAPGSIF KMVTAAAGLE EEVITPDTHI
     ECTGLYTKSG EPAPGCWIYP ITGGGHGSID LQKALEVSCN YYFFEVAHRL GLKYPQTYGG
     IDSLTYYAEM FGLSEPTGIE LPEKSPNIST PETVVKQSMS NVLNGLKNMR EETLTKKVDE
     VSDILKKDLF TDDYYNVEDI ETLALYQVRH TISRKLEPII LSTIGNEITE IAKIAFYSIQ
     GYLQLNIDNM LATIIEDTME NTKSVTLKNK VTTALKEQLF NMIGNITLEV VEEATHNIDV
     NSILEIYQDA YSELYENELK KNENENLIIF LYNEIKMIES LNYKYEKIVK DHIVFGLVDA
     LADYLLQNTN IQWDEGVTIR TAIGQGYNAF SPIQMARYVA AVANGETVYD LKIVGGILDH
     KEKLGYMPTK DKVNGVLNIK DEHIQEIQEG MLRVTQGTAG TSKKLFEGFP INVAGKTGTA
     EEANHTHSWF AGFAPSDNPQ IVVVTSVYNE DNLGSFGSQI AKDVFASYFK VSELPTLDTL
     GDIFLN
//