ID   A0A1V2MBX9_9FIRM        Unreviewed;       448 AA.
AC   A0A1V2MBX9;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 24.
DE   SubName: Full=Melibiose:sodium transporter MelB {ECO:0000313|EMBL:ONI45600.1};
GN   ORFNames=AN641_03755 {ECO:0000313|EMBL:ONI45600.1};
OS   Epulopiscium sp. SCG-C07WGA-EpuloA2.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Lachnospiraceae;
OC   Candidatus Epulonipiscium.
OX   NCBI_TaxID=1712378 {ECO:0000313|EMBL:ONI45600.1, ECO:0000313|Proteomes:UP000189533};
RN   [1] {ECO:0000313|Proteomes:UP000189533}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Ngugi D.K., Miyake S., Stingl U.;
RL   Submitted (AUG-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC       Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC       {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC       {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ONI45600.1}.
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DR   EMBL; LJHE01000024; ONI45600.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V2MBX9; -.
DR   STRING; 1712378.AN641_03755; -.
DR   Proteomes; UP000189533; Unassembled WGS sequence.
DR   GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0015293; F:symporter activity; IEA:InterPro.
DR   GO; GO:0008643; P:carbohydrate transport; IEA:UniProtKB-KW.
DR   GO; GO:0006814; P:sodium ion transport; IEA:InterPro.
DR   CDD; cd17332; MFS_MelB_like; 1.
DR   Gene3D; 1.20.1250.20; MFS general substrate transporter like domains; 1.
DR   InterPro; IPR039672; MFS_2.
DR   InterPro; IPR036259; MFS_trans_sf.
DR   InterPro; IPR001927; Na/Gal_symport.
DR   InterPro; IPR018043; Na/Gal_symport_CS.
DR   NCBIfam; TIGR00792; gph; 1.
DR   PANTHER; PTHR11328; MAJOR FACILITATOR SUPERFAMILY DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR11328:SF36; MELIBIOSE PERMEASE; 1.
DR   Pfam; PF13347; MFS_2; 1.
DR   SUPFAM; SSF103473; MFS general substrate transporter; 1.
DR   PROSITE; PS00872; NA_GALACTOSIDE_SYMP; 1.
PE   4: Predicted;
KW   Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189533};
KW   Sugar transport {ECO:0000256|ARBA:ARBA00022597};
KW   Symport {ECO:0000256|ARBA:ARBA00022847};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        12..32
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        38..56
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        77..96
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        108..130
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        151..172
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        178..200
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        230..255
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        267..286
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        298..317
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        329..350
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        371..392
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        404..426
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
SQ   SEQUENCE   448 AA;  49478 MW;  04E9404F080E6948 CRC64;
     MNKLSNKEKY SYGIGALGKD LVYAIVATYL MIYFTDTVGL SPAFVGTLFL VARLWDAIND
     PFMGMIVDNT RSKFGKFRPW ILIGSLINAV VLVFLFRKPD LQGTSLYVYY SVFYILWGMT
     YTIMDIPYWS MIPALTTDKE EREKVSVIPR IFASTAWLII GTFGLQMIDF FGDGDTAIGY
     YILAIVIAII FVITSITTCF NVTEKAPVKP SAEKVNFKQT LEIIKNNDQL MVFIGIVLCM
     NLVMQIIGGV AIYYFTYVIG NADLFSVYMA FSGISEILGL CAFPFLTKIV GRQNVFKIAV
     GLPIIGCLLL LVVGIIAPTN AIFIGLAGAV YKFGTGLLLG STTVMLSDVV DYGEFKLNSR
     NESIVFSVQT LLVKTASAVS GWLVGVGLQL VGYIPNVQQS DATIFGIKCL MIGAPIVFAI
     IMYIIYKTKY KLNGEFHDKI LASLNKVD
//