ID A0A1V2QXF6_9PSEU Unreviewed; 1686 AA.
AC A0A1V2QXF6;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE SubName: Full=Uncharacterized protein {ECO:0000313|EMBL:ONI92818.1};
GN ORFNames=ALI22I_01680 {ECO:0000313|EMBL:ONI92818.1};
OS Saccharothrix sp. ALI-22-I.
OC Bacteria; Actinomycetota; Actinomycetes; Pseudonocardiales;
OC Pseudonocardiaceae; Saccharothrix.
OX NCBI_TaxID=1933778 {ECO:0000313|EMBL:ONI92818.1, ECO:0000313|Proteomes:UP000188617};
RN [1] {ECO:0000313|EMBL:ONI92818.1, ECO:0000313|Proteomes:UP000188617}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=ALI-22-I {ECO:0000313|EMBL:ONI92818.1,
RC ECO:0000313|Proteomes:UP000188617};
RX PubMed=28087533;
RA Yeager C.M., Gallegos-Graves V., Dunbar J., Hesse C.N., Daligault H.,
RA Kuske C.R.;
RT "Polysaccharide degradation capability of Actinomycetales soil isolates
RT from a semi-arid grassland of the Colorado Plateau.";
RL Appl. Environ. Microbiol. 0:0-0(2017).
CC -!- PATHWAY: Antibiotic biosynthesis. {ECO:0000256|ARBA:ARBA00004792}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ONI92818.1}.
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DR EMBL; MTQP01000026; ONI92818.1; -; Genomic_DNA.
DR RefSeq; WP_077003802.1; NZ_MTQP01000026.1.
DR STRING; 1933778.ALI22I_01680; -.
DR OrthoDB; 9778690at2; -.
DR Proteomes; UP000188617; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0033068; P:macrolide biosynthetic process; IEA:UniProt.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 2.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR016036; Malonyl_transacylase_ACP-bd.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR020807; PKS_DH.
DR InterPro; IPR049552; PKS_DH_N.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR015083; Polyketide_synth_docking.
DR InterPro; IPR036299; Polyketide_synth_docking_sf.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF08990; Docking; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF21089; PKS_DH_N; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00827; PKS_AT; 1.
DR SMART; SM00826; PKS_DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF101173; Docking domain B of the erythromycin polyketide synthase (DEBS); 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR SUPFAM; SSF55048; Probable ACP-binding domain of malonyl-CoA ACP transacylase; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000188617};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 33..457
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT DOMAIN 1528..1603
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
SQ SEQUENCE 1686 AA; 177171 MW; 5BAFEE8085B070C7 CRC64;
MADEDKLRDY LKRAIADARD ARRRLKEVEE REQEPVAIVS MACRYPGGVR SPEDLWRLVA
DGVDAVSDFP DNRGWPDELY DVDPDRVGKS YSRRGGFLHD ADRFDPEFFG MSPREALAVD
PQQRLLMETA WEAFERAGVD PHAVRGSRTG LFTGVMYNDY GSRADLPGRD FEGYLFSGSA
GSIASGRVAY TFGLEGPAVT VDTACSSSLV AMHLAVNALQ RGECDLALAG GVTVMSTPVA
FIEFSRLRGL APDGRCKSFG ASADGTGWAE GVGLLLLERL SDARRRGHRV LAVVRGSAVN
QDGASNGLTA PNGPAQERVI RHALERARLS TSDVDVVEAH GTGTMLGDPI EANALLATYG
QDRVGEPLWL GSLKSNIGHA QAAAGVGGVI KMVQAMRHGV LPRTLHAETP SPHVDWSAGA
VSLLTQARPW PAVDRPRRAA VSSFGFGGTN AHVIIEQAPA PAVASVSAEV VGSPRSGAVP
WVLSAASASA LREQAARLVD VAGEPVDVGF SLATGRAALE HRAVVVGNDR SSLLRGVAAV
AAGDSAADVV FGTRRGGKTA LLFTGQGSQR VGMGLALARE FPVFAEAFDE VCSRFSLDRP
LRSVIESGED LDLTGYAQPA LFALEVALFR LLESWGVRPD VVVGHSIGEL AAAHVAGVFS
LEDACRVVEA RGRLMQALPV GGAMIAVQAS EDEVLPLLKG QSRLALAAVN GPRAVVISGD
ARAAEAVAAQ LAAMGRKTKR LTVSHAFHSP HMEPMLEAFR AVVLGAGLGS ARIPYVSTVG
EAESWESADY WVEQVRRPVR FHDAAARLVD QGVTTTLELG PDAVLTALVP EGVTAVPLLR
AARPEPTTAV LALGQLHAVG VGVDWSGFFG EARFVDLPTY AFQRQRYWLN PTNADSGHPL
LGEPVAVAGT GEVLFTSRVT ADRLPWVPEP FGTPVLPGAG FVEMALRAGD ELGTPAVAEL
TVHAPVVLSG AVHLQLRAGA VDGGWRAVTI HARADDQADW KLHASGTLTA EERAAEPVDG
TRDEYAVEPE EASRYSLHPA LSALAVHEGD RLAHVWRDVR LHAGGAAAVW VGATSGTGVE
LVDAAGLPVL SVGAVELRAV EPAEVSASLP LHETRWVALP ADSGEHAVTW ASAEDPAHPG
AQAVFADFRA TTGDVVASVH ARAGAALDLV QRWLAQDHQG KLVVLTRVDD LAGAAVTGLL
RSVRSENPGR VFTVALDGDD IPFDVLARLV VTDEPEAEVR DGVAYVPKLE RVTGPERGLP
EWGVPEWGVP EWGGTVLITG TGALAAAVAR HLVTAHGVTD LLLVSRRGER APGAAELKAR
LTGLGATVRI EACDVADRDA LAATIAGVPL TAVVHTAGVL DNGLAPTLTA DRLADVLRPK
VDGAWHLHEL ARDVKAFVLF SSVVGIFGGP GQANYAAANA FLDALAVHRA GAGLAATAIA
WGLWGEEAGI NAALDEVARN RFVRDGFRPV TTEEGLALLD AALASGRPAL AATPLAARTR
SVRRAAAEKS TVDFATGLTA LEPAAREKVV LDLVRAEAAA VLGFPDTASV SADRPFQELG
FDSLTAVDLR NRLGAATGVA LPATAVFDHP TPNALAAFVL DAAAPSGKSA VLTELDKLEA
ALSGVGRDVR ERDGKEHAEV AARLRTMLVR WTETGDDEPD HEDAITSATT DEIFDFIDNQ
LGRASS
//
