ID A0A1V2RC40_9ACTN Unreviewed; 404 AA.
AC A0A1V2RC40;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Putative acyltransferase {ECO:0000313|EMBL:ONK10027.1};
DE EC=2.3.1.- {ECO:0000313|EMBL:ONK10027.1};
GN ORFNames=STBA_07330 {ECO:0000313|EMBL:ONK10027.1};
OS Streptomyces sp. MP131-18.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1857892 {ECO:0000313|EMBL:ONK10027.1, ECO:0000313|Proteomes:UP000189065};
RN [1] {ECO:0000313|EMBL:ONK10027.1, ECO:0000313|Proteomes:UP000189065}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MP131-18 {ECO:0000313|EMBL:ONK10027.1,
RC ECO:0000313|Proteomes:UP000189065};
RA Paulus C., Rebets Y., Tokovenko B., Nadmid S., Terekhova L.P.,
RA Myronovskyi M., Zotchev S.B., Rueckert C., Kalinowski J., Luzhetskyy A.;
RT "New natural products identified by combined genomics-metabolomics
RT profiling of marine Streptomyces sp. MP131-18.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Thiolase family.
CC {ECO:0000256|ARBA:ARBA00010982, ECO:0000256|RuleBase:RU003557}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ONK10027.1}.
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DR EMBL; LZNS01000001; ONK10027.1; -; Genomic_DNA.
DR RefSeq; WP_077057847.1; NZ_LZNS01000001.1.
DR AlphaFoldDB; A0A1V2RC40; -.
DR STRING; 1857892.STBA_07330; -.
DR OrthoDB; 9764638at2; -.
DR Proteomes; UP000189065; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR CDD; cd00751; thiolase; 1.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR002155; Thiolase.
DR InterPro; IPR016039; Thiolase-like.
DR InterPro; IPR020610; Thiolase_AS.
DR InterPro; IPR020617; Thiolase_C.
DR InterPro; IPR020613; Thiolase_CS.
DR InterPro; IPR020616; Thiolase_N.
DR NCBIfam; TIGR01930; AcCoA-C-Actrans; 1.
DR PANTHER; PTHR43365; BLR7806 PROTEIN; 1.
DR PANTHER; PTHR43365:SF1; STEROID 3-KETOACYL-COA THIOLASE FADA6; 1.
DR Pfam; PF02803; Thiolase_C; 1.
DR Pfam; PF00108; Thiolase_N; 1.
DR PIRSF; PIRSF000429; Ac-CoA_Ac_transf; 1.
DR SUPFAM; SSF53901; Thiolase-like; 2.
DR PROSITE; PS00737; THIOLASE_2; 1.
DR PROSITE; PS00099; THIOLASE_3; 1.
PE 3: Inferred from homology;
KW Acyltransferase {ECO:0000256|RuleBase:RU003557,
KW ECO:0000313|EMBL:ONK10027.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189065};
KW Transferase {ECO:0000256|RuleBase:RU003557, ECO:0000313|EMBL:ONK10027.1}.
FT DOMAIN 6..230
FT /note="Thiolase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF00108"
FT DOMAIN 282..403
FT /note="Thiolase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02803"
FT ACT_SITE 93
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 360
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
FT ACT_SITE 390
FT /note="Proton acceptor"
FT /evidence="ECO:0000256|PIRSR:PIRSR000429-1"
SQ SEQUENCE 404 AA; 42105 MW; E11D024861688CB8 CRC64;
MTAEAYVYDA IRTPRGRGKA DGALHGTKPI DLAVGLIHAL RERLPDLDPA AIDDVVLGVV
SPHGDQGSDI AKIAAIAAGL PETVAGLQEN RFCGSGLEAV NIAAAKVRSG WDDLILAGGV
ESMSRVPLGS DGGAWAMDPM TNLAVGFVPQ GVGADLIATL EGLGRRDVDE YAALSQERAA
HAWKEGRFAR SVIPVTDRNG LTVLDRDEHI RPGTTADSLA RLKPAFAALG EQGGFDAVAL
QKYHWVERID HVHHAGNSSG IVDGAALVAV GSAAVGERYG LTPRARIRAA AVVGSEPTIM
LTGPAPATRK ALARAGLTID DIDLVEINEA FAAVVLRFVR EMGLDLEKVN VNGGAIAMGH
PLGATGAMIL GTLLDELERR DLRYGLATLC IGGGMGIATV IERV
//
