ID   A0A1V2RH53_9ACTN        Unreviewed;       445 AA.
AC   A0A1V2RH53;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 21.
DE   SubName: Full=PhoH-like protein {ECO:0000313|EMBL:ONK11787.1};
GN   ORFNames=STBA_25230 {ECO:0000313|EMBL:ONK11787.1};
OS   Streptomyces sp. MP131-18.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=1857892 {ECO:0000313|EMBL:ONK11787.1, ECO:0000313|Proteomes:UP000189065};
RN   [1] {ECO:0000313|EMBL:ONK11787.1, ECO:0000313|Proteomes:UP000189065}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=MP131-18 {ECO:0000313|EMBL:ONK11787.1,
RC   ECO:0000313|Proteomes:UP000189065};
RA   Paulus C., Rebets Y., Tokovenko B., Nadmid S., Terekhova L.P.,
RA   Myronovskyi M., Zotchev S.B., Rueckert C., Kalinowski J., Luzhetskyy A.;
RT   "New natural products identified by combined genomics-metabolomics
RT   profiling of marine Streptomyces sp. MP131-18.";
RL   Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- SIMILARITY: Belongs to the PINc/VapC protein family.
CC       {ECO:0000256|ARBA:ARBA00038093}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:ONK11787.1}.
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DR   EMBL; LZNS01000001; ONK11787.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V2RH53; -.
DR   STRING; 1857892.STBA_25230; -.
DR   Proteomes; UP000189065; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0004518; F:nuclease activity; IEA:UniProtKB-KW.
DR   CDD; cd09883; PIN_VapC_PhoHL-ATPase; 1.
DR   Gene3D; 3.40.50.1010; 5'-nuclease; 1.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   InterPro; IPR003714; PhoH.
DR   InterPro; IPR029060; PIN-like_dom_sf.
DR   InterPro; IPR002716; PIN_dom.
DR   PANTHER; PTHR30473:SF2; PIN DOMAIN-CONTAINING PROTEIN; 1.
DR   PANTHER; PTHR30473; PROTEIN PHOH; 1.
DR   Pfam; PF02562; PhoH; 1.
DR   Pfam; PF13638; PIN_4; 1.
DR   SMART; SM00670; PINc; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR   SUPFAM; SSF88723; PIN domain-like; 1.
PE   3: Inferred from homology;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW   Nuclease {ECO:0000256|ARBA:ARBA00022722};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189065};
KW   Toxin-antitoxin system {ECO:0000256|ARBA:ARBA00022649}.
FT   DOMAIN          12..144
FT                   /note="PIN"
FT                   /evidence="ECO:0000259|SMART:SM00670"
SQ   SEQUENCE   445 AA;  48795 MW;  8F287408E7D7E8FC CRC64;
     MATSKKRSHD RRMYVLDTSV LLADPAAITR FDEHEVVLPV VVISELEAKR HHPELGYFAR
     QVLRRLDGYR VRFGRLDTPL PIGDLGGTLR VELNHSDPTV LPPAMLNERG RLADNDSRIL
     AVARNLQAEG HDVTVVSKDL PLRIKASSVG LAAEEYRAEL AITDSDGWTG LVEMPMSAEA
     VDELFATESL HDETAATLPV HTGLVISSER GRALGRVAPD GRVRLVRGDR EAFGIHGRSA
     EQRIALDLLL DPEVGIVSMG GRAGTGKSAL ALCAGLEAVL ERRQHSRVVV FRPLYAVGGQ
     DLGYLPGTEA EKMNPWAQAV FDTLSAVTTR EVIEEVVARG MLEVLPLTHI RGRSLHDAFV
     IVDEAQSLER NVLLTVLSRI GQDSRVVLTH DVAQRDNLRV GRYDGVVAVV EKLKGHPLFA
     HVTLTRSERS PIAALVTEML EDDRI
//