ID A0A1V2RMF3_9ACTN Unreviewed; 966 AA.
AC A0A1V2RMF3;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Regulatory protein AfsR {ECO:0000313|EMBL:ONK13637.1};
GN ORFNames=STBA_44070 {ECO:0000313|EMBL:ONK13637.1};
OS Streptomyces sp. MP131-18.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1857892 {ECO:0000313|EMBL:ONK13637.1, ECO:0000313|Proteomes:UP000189065};
RN [1] {ECO:0000313|EMBL:ONK13637.1, ECO:0000313|Proteomes:UP000189065}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MP131-18 {ECO:0000313|EMBL:ONK13637.1,
RC ECO:0000313|Proteomes:UP000189065};
RA Paulus C., Rebets Y., Tokovenko B., Nadmid S., Terekhova L.P.,
RA Myronovskyi M., Zotchev S.B., Rueckert C., Kalinowski J., Luzhetskyy A.;
RT "New natural products identified by combined genomics-metabolomics
RT profiling of marine Streptomyces sp. MP131-18.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ONK13637.1}.
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DR EMBL; LZNS01000001; ONK13637.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V2RMF3; -.
DR STRING; 1857892.STBA_44070; -.
DR Proteomes; UP000189065; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 2.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF13424; TPR_12; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00028; TPR; 5.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS51755; OMPR_PHOB; 1.
DR PROSITE; PS50005; TPR; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01091}; Reference proteome {ECO:0000313|Proteomes:UP000189065};
KW TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 1..99
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT REPEAT 860..893
FT /note="TPR"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT DNA_BIND 1..99
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
FT REGION 249..270
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 940..966
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 966 AA; 104526 MW; 07E30A651CBA6CB0 CRC64;
MRVNGVEFRL LGAVGVWQGA RLVGPHTAQQ RTVLAMLLLE PGRVVSMDRL VTALWNRQPP
ASARNAVQGC VSRLRRTLAQ LSGVEAELTT SAQGYCLWVD RDLVDLHRFR HLVHRAQRSE
PALGHELLGR GLAMWRGTAL TDVAGGWLPE AVVPALEEER LAAQEERAAL DLTLGRPQDA
AAGLSGLVAA HPLRERPVSL LLTALHRTGR RAEALALFRR VRDQFTDELG IEPGEELHRA
HQAVLLGEDT GGTANASPPG EPSRAAEEPG AAAVAVPRQL PPDVEHFTSR THELDALDAL
ARKDRGGGGA PVICVIAGTG GVGKTALAVH WAHRARDLYP DGQLYVNLRG FGPTDAAMTP
ADVVRVFLDA LQVPGDRIPA AFEAQVGLFR GLLADRRMLI VLDNARDAEQ VRPLLPTSPG
SLVLVTSRNE LTGLAVTEGA HQLPLDLLSA VESRELLVRR LGSREFAAQQ GTADDVIAMC
AGLPLALAIV AARAATQPGL PLTTLRGCKA DDELEAGDGL DVFESGDPST DVRTVFSWSY
RALSPAGARV FRLLGLVDSP DITLPAAASL AGLPVAQTRR LLSELLRAHL VGQRVPGRYS
SHDLLWTYAR ELALERDGEA ERREALHRLL DHYVHSAVPG DALLNPAVTA SIDPAPALPG
VTVTRPAEVT RARAWFAGQL PALLAAARQA AHHGFHAHAA QLAHASRAFL FQEGHAQHQV
TMHRIALDAA RHIDDLPAQA LSHIGLGQAY YRIGDYAGTE EHVFLALRIY EEQDDVTGQA
RAHTHLGYLR HQQGKHQEGL VHATRALDLH RASRHRVGEA QELNNIGWFH AVLGAYEEAL
RYCEKALAMH RALGNAGGES STLDSLGLIH HRLGDHERAI SYYERALVWR TDRERVSGAE
TLTRLAEAQA DAGRPAEARR SLRRALDMLD EFAHPDAESV RTRLAELDTA APRNGAAPQA
GPGRRR
//
