ID A0A1V2RMI2_9ACTN Unreviewed; 977 AA.
AC A0A1V2RMI2;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE SubName: Full=Regulatory protein AfsR {ECO:0000313|EMBL:ONK13643.1};
GN ORFNames=STBA_44130 {ECO:0000313|EMBL:ONK13643.1};
OS Streptomyces sp. MP131-18.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1857892 {ECO:0000313|EMBL:ONK13643.1, ECO:0000313|Proteomes:UP000189065};
RN [1] {ECO:0000313|EMBL:ONK13643.1, ECO:0000313|Proteomes:UP000189065}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MP131-18 {ECO:0000313|EMBL:ONK13643.1,
RC ECO:0000313|Proteomes:UP000189065};
RA Paulus C., Rebets Y., Tokovenko B., Nadmid S., Terekhova L.P.,
RA Myronovskyi M., Zotchev S.B., Rueckert C., Kalinowski J., Luzhetskyy A.;
RT "New natural products identified by combined genomics-metabolomics
RT profiling of marine Streptomyces sp. MP131-18.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the AfsR/DnrI/RedD regulatory family.
CC {ECO:0000256|ARBA:ARBA00005820}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ONK13643.1}.
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DR EMBL; LZNS01000001; ONK13643.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V2RMI2; -.
DR STRING; 1857892.STBA_44130; -.
DR OrthoDB; 3845029at2; -.
DR Proteomes; UP000189065; Unassembled WGS sequence.
DR GO; GO:0043531; F:ADP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0000160; P:phosphorelay signal transduction system; IEA:UniProtKB-KW.
DR GO; GO:0006355; P:regulation of DNA-templated transcription; IEA:InterPro.
DR CDD; cd15831; BTAD; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 3.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR005158; BTAD.
DR InterPro; IPR002182; NB-ARC.
DR InterPro; IPR001867; OmpR/PhoB-type_DNA-bd.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016032; Sig_transdc_resp-reg_C-effctor.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR InterPro; IPR019734; TPR_repeat.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR PANTHER; PTHR35807:SF1; TRANSCRIPTIONAL REGULATOR REDD; 1.
DR PANTHER; PTHR35807; TRANSCRIPTIONAL REGULATOR REDD-RELATED; 1.
DR Pfam; PF03704; BTAD; 1.
DR Pfam; PF00931; NB-ARC; 1.
DR Pfam; PF00486; Trans_reg_C; 1.
DR PRINTS; PR00364; DISEASERSIST.
DR SMART; SM01043; BTAD; 1.
DR SMART; SM00028; TPR; 4.
DR SMART; SM00862; Trans_reg_C; 1.
DR SUPFAM; SSF46894; C-terminal effector domain of the bipartite response regulators; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48452; TPR-like; 3.
DR PROSITE; PS51755; OMPR_PHOB; 1.
PE 3: Inferred from homology;
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|PROSITE-
KW ProRule:PRU01091}; Reference proteome {ECO:0000313|Proteomes:UP000189065};
KW Two-component regulatory system {ECO:0000256|ARBA:ARBA00023012}.
FT DOMAIN 4..105
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000259|PROSITE:PS51755"
FT DNA_BIND 4..105
FT /note="OmpR/PhoB-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU01091"
SQ SEQUENCE 977 AA; 104105 MW; 45E2BDA9B3D96ECF CRC64;
MVVGEGTTGG HTPTLHFAVL GPVRAWQGDR PLPSGSPQQR ALLAALLLRR GRTATAQELV
NALWGEDPPQ QALAALRTYA SRLRKAFGSR TDVLVTELGG YALRLGPFDE LDADTVVKLT
TSAEKAAAAG DPMRAHELYG KALARWDGEA LGGVPGPDAE VARTQLAEQR LILQEQRLDV
GLQAGLHAES VSELTALTTS HPLRERLREL LMLALYRSGR QAEALAVYAD ARKLLIDELG
VEPRAELAEL QQRILNADSS LSQAARTAAA ATLPVIRPAQ LPAAVPDFTG RAAFVAELGA
QLATVGGRVM VVSAVAGIGG VGKTTLAVQV AHAAREHFPD GQLYVDLHGA GASPADPATV
LGSFLRALGV TDASMPEGLA ERAALYRSLL DGRRLLILLD NARDAAQVRH LLPGTADCAT
LITSRVRMVD LAGAHLVDLD VMSPEEALTL FTRIVGPERV NAERDAAMDV VASCGFLPLA
IRIAASRLAA RRTWTVSTLA RKLSDERGRL DELQAGDQAV KATFELGYGQ LSREQARAFR
LLGLADGPDI SLLSAAALLD RGHGATETLL ESLVDTSLVE SAAPGRYRFH DLVRLFARAC
AERDEQPPAE REAATSRLLD FYLATTANVY ESERPGDRTT AHLEPTQYPG LAFGTPAAAV
DWLFTEADCL LAAVQGALSG ERLRKAADLL LVARDLSESG AFSLPYERAS EATLRAARAA
GDARTEGRAR IALAMAGSHA GRFDSAYEHG RRAMLLGTAA DDPVTRSHAA NEQGIIALYL
GRHGEAEEYL TRAFNEFGEY GNQPGEASAL GNLVRVSLKA GATEKAVQLA HRTLGILRSL
GSDLRLANGL YALGQALSED GRHEAALHQF TVALKTFSSH RQRLWEGMTH FRMAETHIAM
GSPAEAARLC ELGLAQLRGV GGEWRRANVL TLLGRALLDI GQEGRGEACL QQALEIFDEQ
GSPEAAAVRN LLGSSAV
//
