ID A0A1V2RU60_9ACTN Unreviewed; 789 AA.
AC A0A1V2RU60;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 24.
DE SubName: Full=Erythronolide synthase, modules 3 and 4 {ECO:0000313|EMBL:ONK15963.1};
DE EC=2.3.1.94 {ECO:0000313|EMBL:ONK15963.1};
GN ORFNames=STBA_68070 {ECO:0000313|EMBL:ONK15963.1};
OS Streptomyces sp. MP131-18.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1857892 {ECO:0000313|EMBL:ONK15963.1, ECO:0000313|Proteomes:UP000189065};
RN [1] {ECO:0000313|EMBL:ONK15963.1, ECO:0000313|Proteomes:UP000189065}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MP131-18 {ECO:0000313|EMBL:ONK15963.1,
RC ECO:0000313|Proteomes:UP000189065};
RA Paulus C., Rebets Y., Tokovenko B., Nadmid S., Terekhova L.P.,
RA Myronovskyi M., Zotchev S.B., Rueckert C., Kalinowski J., Luzhetskyy A.;
RT "New natural products identified by combined genomics-metabolomics
RT profiling of marine Streptomyces sp. MP131-18.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ONK15963.1}.
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DR EMBL; LZNS01000001; ONK15963.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V2RU60; -.
DR STRING; 1857892.STBA_68070; -.
DR Proteomes; UP000189065; Unassembled WGS sequence.
DR GO; GO:0047879; F:erythronolide synthase activity; IEA:UniProtKB-EC.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProt.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR Gene3D; 3.10.129.110; Polyketide synthase dehydratase; 1.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR042104; PKS_dehydratase_sf.
DR InterPro; IPR049551; PKS_DH_C.
DR InterPro; IPR013968; PKS_KR.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF08659; KR; 1.
DR Pfam; PF00550; PP-binding; 1.
DR Pfam; PF14765; PS-DH; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 2.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000313|EMBL:ONK15963.1};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000189065};
KW Transferase {ECO:0000313|EMBL:ONK15963.1}.
FT DOMAIN 620..695
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT REGION 739..768
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 789 AA; 81126 MW; 2FF0D78775B5FE6A CRC64;
MTAEVAAVVD EDLSGTWPPA GAEAVPLPGF YERLAEDGYE YGPAFRGLRA AWRRGEEIFA
EVRLPEERHG DDFDLHPALL DAALHTSLVG GVDEVRLPFS WAGVTLHATG ATALRVRLTP
TGPDTMSLAL ADETGAPVAT VESLAVRPVR AEQLRDVVGD ALFGVDWAEV PPVSADAPHQ
APVESAELLP GEPAPPAVAL RWLPEPGGDP AEAVVRALAS LQEWLTDGRF VASRLVWVTR
GAVSVSEGED VTDLAGAAVW GAVRSAQAEH PGRIVLVDLD AASADGGGEP AVLPSALPLD
AEPQLAVRGG RVLAPRLARL RRPAAAPAWP GLGGTVLITG GTGTLGGLVA RHLVEAHGVR
HLLLVSRRGP RAAGADRLVT ELTGLGAEVT MVACDAADRD ALAAVLDTVP ADRPLAGVVH
AAGVLDDGVL GSLTPERVRA VVRPKADAAR HLHDLTRDAD LSMFVLFSAA GGVLGAAGQA
NYAAANAFLD ALAQRRRARG LPAVSMGWGL WEAASGMTGG LDGTDRARMR RSGVLPLASA
DGLALFDAAL AEGRPVVLPV RLDLAAVREA QEPPPLLRRL VDTAARRVVR ARAAVGAGAE
RDAAGFPGGL AGLPAAERAE ALVDLVRSHV ATVLGLAGPG QVDVGRGFLE SGFDSLRAVE
LRNRLGAATG LRLPATLIFD FPTAAALAAH LDAQLVPESA VPPVLARLDG VEAGLAGLSP
DDPVRGLLAA RLQSLLTRLG GNGQNGGNGE NGENGAGRPG GTNAGGSGEI EAAGLEEIFD
IVENELRNS
//
