ID A0A1V2RUZ2_9ACTN Unreviewed; 305 AA.
AC A0A1V2RUZ2;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 15.
DE RecName: Full=UTP--glucose-1-phosphate uridylyltransferase {ECO:0000256|ARBA:ARBA00012415};
DE EC=2.7.7.9 {ECO:0000256|ARBA:ARBA00012415};
GN ORFNames=STBA_70830 {ECO:0000313|EMBL:ONK16233.1};
OS Streptomyces sp. MP131-18.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1857892 {ECO:0000313|EMBL:ONK16233.1, ECO:0000313|Proteomes:UP000189065};
RN [1] {ECO:0000313|EMBL:ONK16233.1, ECO:0000313|Proteomes:UP000189065}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MP131-18 {ECO:0000313|EMBL:ONK16233.1,
RC ECO:0000313|Proteomes:UP000189065};
RA Paulus C., Rebets Y., Tokovenko B., Nadmid S., Terekhova L.P.,
RA Myronovskyi M., Zotchev S.B., Rueckert C., Kalinowski J., Luzhetskyy A.;
RT "New natural products identified by combined genomics-metabolomics
RT profiling of marine Streptomyces sp. MP131-18.";
RL Submitted (JUN-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=alpha-D-glucose 1-phosphate + H(+) + UTP = diphosphate + UDP-
CC alpha-D-glucose; Xref=Rhea:RHEA:19889, ChEBI:CHEBI:15378,
CC ChEBI:CHEBI:33019, ChEBI:CHEBI:46398, ChEBI:CHEBI:58601,
CC ChEBI:CHEBI:58885; EC=2.7.7.9;
CC Evidence={ECO:0000256|ARBA:ARBA00000872};
CC -!- SIMILARITY: Belongs to the UDPGP type 2 family.
CC {ECO:0000256|ARBA:ARBA00006890}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ONK16233.1}.
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DR EMBL; LZNS01000001; ONK16233.1; -; Genomic_DNA.
DR RefSeq; WP_077062983.1; NZ_LZNS01000001.1.
DR AlphaFoldDB; A0A1V2RUZ2; -.
DR STRING; 1857892.STBA_70830; -.
DR OrthoDB; 9803306at2; -.
DR Proteomes; UP000189065; Unassembled WGS sequence.
DR GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase activity; IEA:UniProtKB-EC.
DR GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR CDD; cd02541; UGPase_prokaryotic; 1.
DR InterPro; IPR005771; GalU_uridylyltTrfase_bac/arc.
DR InterPro; IPR005835; NTP_transferase_dom.
DR InterPro; IPR029044; Nucleotide-diphossugar_trans.
DR PANTHER; PTHR43197; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR PANTHER; PTHR43197:SF1; UTP--GLUCOSE-1-PHOSPHATE URIDYLYLTRANSFERASE; 1.
DR Pfam; PF00483; NTP_transferase; 1.
DR SUPFAM; SSF53448; Nucleotide-diphospho-sugar transferases; 1.
PE 3: Inferred from homology;
KW Nucleotidyltransferase {ECO:0000313|EMBL:ONK16233.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000189065};
KW Transferase {ECO:0000313|EMBL:ONK16233.1}.
FT DOMAIN 8..276
FT /note="Nucleotidyl transferase"
FT /evidence="ECO:0000259|Pfam:PF00483"
SQ SEQUENCE 305 AA; 32977 MW; 33C1A57D546F586F CRC64;
MAPTISRAVI PAAGLGSRLL PLTKAIPKEM LPVGDMPVIE HTVRELVASG ITDITIVISG
GKSLIQEHFR PNPALVERLR ADGKTAYAQA VEEVAELARQ GHITYLDQHG PYGNGTPVLN
AARHFRDEPM LVLWPDDVFV AAVPRAQQLI RAFEATHCPV LALMPMEAAD APRYGVPVVK
EDLDNGLLRI TGLVEKPKPA DAPSAFAAIG GYVITPGIVD ELREQTRRWY EHRRGEIYLT
DAINAYAAGR AVYGQVISGR WYDTGNPADY LVAQMASALA HPEYGPVLRR LARDLDGELA
GGVGG
//
