ID A0A1V2TDQ0_9NOCA Unreviewed; 947 AA.
AC A0A1V2TDQ0;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00012417};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
GN ORFNames=B0T46_18115 {ECO:0000313|EMBL:ONM47471.1};
OS Nocardia donostiensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1538463 {ECO:0000313|EMBL:ONM47471.1, ECO:0000313|Proteomes:UP000188836};
RN [1] {ECO:0000313|EMBL:ONM47471.1, ECO:0000313|Proteomes:UP000188836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=X1655 {ECO:0000313|EMBL:ONM47471.1,
RC ECO:0000313|Proteomes:UP000188836};
RX PubMed=26914251; DOI=10.1007/s10482-016-0667-8;
RA Ercibengoa M., Bell M., Marimon J.M., Humrighouse B., Klenk H.P.,
RA Potter G., Perez-Trallero E.;
RT "Nocardia donostiensis sp. nov., isolated from human respiratory
RT specimens.";
RL Antonie Van Leeuwenhoek 109:653-660(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- SIMILARITY: Belongs to the DnaX/STICHEL family.
CC {ECO:0000256|ARBA:ARBA00006360}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ONM47471.1}.
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DR EMBL; MUMY01000015; ONM47471.1; -; Genomic_DNA.
DR RefSeq; WP_077118812.1; NZ_MUMY01000015.1.
DR AlphaFoldDB; A0A1V2TDQ0; -.
DR STRING; 1538463.B0T36_14930; -.
DR OrthoDB; 9810148at2; -.
DR Proteomes; UP000188836; Unassembled WGS sequence.
DR GO; GO:0009360; C:DNA polymerase III complex; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:InterPro.
DR GO; GO:0006260; P:DNA replication; IEA:InterPro.
DR CDD; cd00009; AAA; 1.
DR CDD; cd18137; HLD_clamp_pol_III_gamma_tau; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 1.20.272.10; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR008921; DNA_pol3_clamp-load_cplx_C.
DR InterPro; IPR022754; DNA_pol_III_gamma-3.
DR InterPro; IPR012763; DNA_pol_III_sug/sutau_N.
DR InterPro; IPR045085; HLD_clamp_pol_III_gamma_tau.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR02397; dnaX_nterm; 1.
DR PANTHER; PTHR11669:SF0; PROTEIN STICHEL-LIKE 2; 1.
DR PANTHER; PTHR11669; REPLICATION FACTOR C / DNA POLYMERASE III GAMMA-TAU SUBUNIT; 1.
DR Pfam; PF13177; DNA_pol3_delta2; 1.
DR Pfam; PF12169; DNA_pol3_gamma3; 1.
DR SMART; SM00382; AAA; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF48019; post-AAA+ oligomerization domain-like; 1.
PE 3: Inferred from homology;
KW DNA-directed DNA polymerase {ECO:0000256|ARBA:ARBA00022932};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022932};
KW Reference proteome {ECO:0000313|Proteomes:UP000188836};
KW Transferase {ECO:0000256|ARBA:ARBA00022932}.
FT DOMAIN 34..177
FT /note="AAA+ ATPase"
FT /evidence="ECO:0000259|SMART:SM00382"
FT REGION 387..676
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 764..929
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 391..406
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..542
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 947 AA; 97304 MW; B1D5F623F4D866CD CRC64;
MALYRKYRPA TFAEVVGQEH VTDPLSTALD SGRISHAYLF SGPRGCGKTS SARILARSLN
CVEGPTSTPC GQCPSCMALG PGGAGNLDVI ELDAASHGGV DDTRELRDRA FYAPAESRYR
VFIVDEAHMV TTAGFNALLK IVEEPPAHLI FVFATTEPDK VLPTIRSRTH HYPFRLLPPA
TMRGLLGRIC EQEHVPVEEA VYPLVIRAGG GSPRDSLSVL DQLLAGAGPE GVTYSRAVAL
LGVTDIALID DAVDALATTD GAALFGTVDR VMEAGHDPRR FAVDLLERLR DLILLRAVPD
AADRGLVAAP ADQLERMSDQ ASRIGPASLT RYAELLHAGL GEMRGATAPR LLLEVVCARM
LLPAASDAEA ATLQRLEQLE RQVATGAVSA PAAATDSSER TAPASSPSPA SGPPRRRGAE
ALAAVRESRA AKAAVPDVVD AAAREKPQEE PQHGGSASGA PGRPAQPSDT EPVPSAGPGN
RPDETRPDHA AEQYEPTPPE TSRSREGSTE RADVADGRAR TEPVHPDPAT HGGGRESRRD
AGAFRSASGT SDAGVPMSSE RAASAEGGAP GDSPMSPRRS GQGEGSTGSH DPGRPAPGGS
GHELGAKGPD QPTDPTQVPY GRADANAASS PSAAGYEGPD NRAPAHGPAA RGSASVSRGG
TDHAADLSGP APSPAADPLA EIEAAWGDIK TRVREFSVAV AAMLASGASV VRVEGEVIVF
AHQHAALVQR LSNQQSLDAV RSAVGAVLGR DYQVKWVTAA AAGGRQAVGG PGNRGRGGGR
EAGGRRSGSA DGTGGPDAER GKTVDGPIAP PGRGAEPEGY GTRPSGGDGE PAGHGSRGRG
RRGSAGAPPR FSRPSQARSG GSGGNGGSVY PDDDIPPPDY PDFPDDPGPA DYGYDSGPAA
VPPSTPEEEQ EMLAESARPV APGDRRDPDE VALELLASEL GAVRLDG
//