ID A0A1V2TKV8_9NOCA Unreviewed; 380 AA.
AC A0A1V2TKV8;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 19.
DE RecName: Full=Type III polyketide synthase {ECO:0008006|Google:ProtNLM};
GN ORFNames=B0T46_03400 {ECO:0000313|EMBL:ONM50144.1};
OS Nocardia donostiensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1538463 {ECO:0000313|EMBL:ONM50144.1, ECO:0000313|Proteomes:UP000188836};
RN [1] {ECO:0000313|EMBL:ONM50144.1, ECO:0000313|Proteomes:UP000188836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=X1655 {ECO:0000313|EMBL:ONM50144.1,
RC ECO:0000313|Proteomes:UP000188836};
RX PubMed=26914251; DOI=10.1007/s10482-016-0667-8;
RA Ercibengoa M., Bell M., Marimon J.M., Humrighouse B., Klenk H.P.,
RA Potter G., Perez-Trallero E.;
RT "Nocardia donostiensis sp. nov., isolated from human respiratory
RT specimens.";
RL Antonie Van Leeuwenhoek 109:653-660(2016).
CC -!- SIMILARITY: Belongs to the thiolase-like superfamily. Chalcone/stilbene
CC synthases family. {ECO:0000256|ARBA:ARBA00005531}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ONM50144.1}.
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DR EMBL; MUMY01000002; ONM50144.1; -; Genomic_DNA.
DR RefSeq; WP_077114963.1; NZ_MUMY01000002.1.
DR AlphaFoldDB; A0A1V2TKV8; -.
DR STRING; 1538463.B0T36_07495; -.
DR OrthoDB; 9786288at2; -.
DR Proteomes; UP000188836; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:InterPro.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:InterPro.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR Gene3D; 3.40.47.10; -; 2.
DR InterPro; IPR012328; Chalcone/stilbene_synt_C.
DR InterPro; IPR013601; FAE1_typ3_polyketide_synth.
DR InterPro; IPR011141; Polyketide_synthase_type-III.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR11877:SF99; 1,3,6,8-TETRAHYDROXYNAPHTHALENE SYNTHASE; 1.
DR PANTHER; PTHR11877; HYDROXYMETHYLGLUTARYL-COA SYNTHASE; 1.
DR Pfam; PF02797; Chal_sti_synt_C; 1.
DR Pfam; PF08392; FAE1_CUT1_RppA; 1.
DR PIRSF; PIRSF000451; PKS_III; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000188836}.
FT DOMAIN 90..212
FT /note="FAE"
FT /evidence="ECO:0000259|Pfam:PF08392"
FT DOMAIN 222..356
FT /note="Chalcone/stilbene synthase C-terminal"
FT /evidence="ECO:0000259|Pfam:PF02797"
FT ACT_SITE 143
FT /note="Acyl-thioester intermediate"
FT /evidence="ECO:0000256|PIRSR:PIRSR000451-1"
SQ SEQUENCE 380 AA; 39757 MW; 0F540E592740095A CRC64;
MSVPVVTVPP HEIPHPELVD AVRSRYEKVF PPGSPRSLAV DRALAMAGRL AIDVHPMHLR
TDEIMSMQGF AARNAAAWDA FHAYAVPAAR AALASVQCTG ADIDLVILET STLIAMPSPI
SALAQAVGLR QDCAALPISG MGCRGGAHAI TMAHAWLRAH PRDTVLIVTA DIASPHFHVE
TDLDEAALVG SIVSSALFSD AAAAAVVSTS LEEGIELVDI ARYEVPGTPD AITWVVTDEG
LRFRLTTDAV RSIPSVAPTL RALLAGQGWT GADLAVCALH SGGNNIIRDV QQSLGLDRHQ
VAPAWQSLTR GNLMSSAVLD AIALIAADPR LRPAWGAPLL GVGFGPGFGT DAFVGRALLP
DLDIHGADNE TAVRRDVAVG
//
