ID A0A1V2TLN5_9NOCA Unreviewed; 552 AA.
AC A0A1V2TLN5;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 25.
DE RecName: Full=DNA helicase {ECO:0000256|ARBA:ARBA00012551};
DE EC=3.6.4.12 {ECO:0000256|ARBA:ARBA00012551};
GN ORFNames=B0T46_00115 {ECO:0000313|EMBL:ONM50383.1};
OS Nocardia donostiensis.
OC Bacteria; Actinomycetota; Actinomycetes; Mycobacteriales; Nocardiaceae;
OC Nocardia.
OX NCBI_TaxID=1538463 {ECO:0000313|EMBL:ONM50383.1, ECO:0000313|Proteomes:UP000188836};
RN [1] {ECO:0000313|EMBL:ONM50383.1, ECO:0000313|Proteomes:UP000188836}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=X1655 {ECO:0000313|EMBL:ONM50383.1,
RC ECO:0000313|Proteomes:UP000188836};
RX PubMed=26914251; DOI=10.1007/s10482-016-0667-8;
RA Ercibengoa M., Bell M., Marimon J.M., Humrighouse B., Klenk H.P.,
RA Potter G., Perez-Trallero E.;
RT "Nocardia donostiensis sp. nov., isolated from human respiratory
RT specimens.";
RL Antonie Van Leeuwenhoek 109:653-660(2016).
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=3.6.4.12;
CC Evidence={ECO:0000256|ARBA:ARBA00001665};
CC -!- SIMILARITY: Belongs to the helicase family. RAD25/XPB subfamily.
CC {ECO:0000256|ARBA:ARBA00006637}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:ONM50383.1}.
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DR EMBL; MUMY01000001; ONM50383.1; -; Genomic_DNA.
DR RefSeq; WP_077114159.1; NZ_MUMY01000001.1.
DR AlphaFoldDB; A0A1V2TLN5; -.
DR STRING; 1538463.B0T36_02045; -.
DR OrthoDB; 3713880at2; -.
DR Proteomes; UP000188836; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0004386; F:helicase activity; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:InterPro.
DR CDD; cd18789; SF2_C_XPB; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR032438; ERCC3_RAD25_C.
DR InterPro; IPR006935; Helicase/UvrB_N.
DR InterPro; IPR014001; Helicase_ATP-bd.
DR InterPro; IPR001650; Helicase_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR032830; XPB/Ssl2_N.
DR PANTHER; PTHR11274:SF0; GENERAL TRANSCRIPTION AND DNA REPAIR FACTOR IIH HELICASE SUBUNIT XPB; 1.
DR PANTHER; PTHR11274; RAD25/XP-B DNA REPAIR HELICASE; 1.
DR Pfam; PF16203; ERCC3_RAD25_C; 1.
DR Pfam; PF13625; Helicase_C_3; 1.
DR Pfam; PF04851; ResIII; 1.
DR PRINTS; PR00851; XRODRMPGMNTB.
DR SMART; SM00487; DEXDc; 1.
DR SMART; SM00490; HELICc; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
DR PROSITE; PS51192; HELICASE_ATP_BIND_1; 1.
DR PROSITE; PS51194; HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000313|EMBL:ONM50383.1};
KW Helicase {ECO:0000313|EMBL:ONM50383.1};
KW Hydrolase {ECO:0000313|EMBL:ONM50383.1};
KW Nucleotide-binding {ECO:0000313|EMBL:ONM50383.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000188836}.
FT DOMAIN 192..346
FT /note="Helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51192"
FT DOMAIN 400..546
FT /note="Helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51194"
SQ SEQUENCE 552 AA; 61053 MW; 734608BE4C4D320A CRC64;
MTDGPLIVQS DKTLLLEVDH ELADAARQAI APFAELERAP EHVHTYRVTP LALWNARAAG
HDAEQVVDAL VSYSRYAVPQ PLLVDIVDTM ARYGRLQLVK HPAHGLTMVS LDRAVLEEVL
RHKKIAPMLG ARIDDDTVVV HASERGHIKQ MLLKIGWPAE DLAGYVDGEA HPIELDFAGG
HWQLRDYQEM ATDSFWAGGS GVVVLPCGAG KTMVGAAAMA KAKATTLILV TNTVAGRQWR
RELLARTSLT EEEIGEYSGE RKEIRPVTIA TYQVITRRSK GEYKHLELFD SRDWGLVIYD
EVHLLPAPVF RMTADLQSRR RLGLTATLVR EDGREGDVFS LIGPKRYDAP WKDIEAQGWI
APADCIEVRV TLTDAERMTY ATAEPDERYK LCSTARTKIA VVESILAAHK DAPTLVIGAY
LEQLDELGVA LDAPVIQGST KTKEREALFD AFRRGEIPVL VVSKVANFSI DLPEASVAVQ
VSGTFGSRQE EAQRLGRLLR PKHDGGQAHF YSVVARDTLD AEYAAHRQRF LAEQGYAYRI
TDADDLLGPT IG
//