ID   A0A1V3A378_9GAMM        Unreviewed;       598 AA.
AC   A0A1V3A378;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 27.
DE   RecName: Full=Arsenical pump-driving ATPase {ECO:0000256|PIRNR:PIRNR001327};
DE            EC=7.3.2.7 {ECO:0000256|PIRNR:PIRNR001327};
GN   ORFNames=B1A74_00025 {ECO:0000313|EMBL:OOC11543.1};
OS   Thioalkalivibrio halophilus.
OC   Bacteria; Pseudomonadota; Gammaproteobacteria; Chromatiales;
OC   Ectothiorhodospiraceae; Thioalkalivibrio.
OX   NCBI_TaxID=252474 {ECO:0000313|EMBL:OOC11543.1, ECO:0000313|Proteomes:UP000189177};
RN   [1] {ECO:0000313|EMBL:OOC11543.1, ECO:0000313|Proteomes:UP000189177}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=HL17 {ECO:0000313|EMBL:OOC11543.1,
RC   ECO:0000313|Proteomes:UP000189177};
RA   Ahn A.-C., Meier-Kolthoff J., Overmars L., Richter M., Woyke T.,
RA   Sorokin D.Y., Muyzer G.;
RT   "Genomic diversity within the haloalkaliphilic genus Thioalkalivibrio.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- FUNCTION: Anion-transporting ATPase. {ECO:0000256|PIRNR:PIRNR001327}.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=arsenite(in) + ATP + H2O = ADP + arsenite(out) + H(+) +
CC         phosphate; Xref=Rhea:RHEA:11348, ChEBI:CHEBI:15377,
CC         ChEBI:CHEBI:15378, ChEBI:CHEBI:29242, ChEBI:CHEBI:30616,
CC         ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=7.3.2.7;
CC         Evidence={ECO:0000256|PIRNR:PIRNR001327};
CC   -!- SIMILARITY: Belongs to the arsA ATPase family.
CC       {ECO:0000256|ARBA:ARBA00011040, ECO:0000256|PIRNR:PIRNR001327}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OOC11543.1}.
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DR   EMBL; MUZR01000001; OOC11543.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V3A378; -.
DR   STRING; 252474.B1A74_00025; -.
DR   OrthoDB; 9780677at2; -.
DR   Proteomes; UP000189177; Unassembled WGS sequence.
DR   GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR   GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR   GO; GO:0015446; F:ATPase-coupled arsenite transmembrane transporter activity; IEA:UniProtKB-UniRule.
DR   CDD; cd02035; ArsA; 2.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR   InterPro; IPR003593; AAA+_ATPase.
DR   InterPro; IPR025723; Anion-transp_ATPase-like_dom.
DR   InterPro; IPR027541; Ars_ATPase.
DR   InterPro; IPR016300; ATPase_ArsA/GET3.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   NCBIfam; TIGR04291; arsen_driv_ArsA; 1.
DR   NCBIfam; TIGR00345; GET3_arsA_TRC40; 1.
DR   PANTHER; PTHR10803; ARSENICAL PUMP-DRIVING ATPASE ARSENITE-TRANSLOCATING ATPASE; 1.
DR   PANTHER; PTHR10803:SF3; ATPASE GET3; 1.
DR   Pfam; PF02374; ArsA_ATPase; 2.
DR   PIRSF; PIRSF001327; Arsenical_pump-driving_ATPase; 1.
DR   SMART; SM00382; AAA; 2.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 2.
PE   3: Inferred from homology;
KW   Arsenical resistance {ECO:0000256|PIRNR:PIRNR001327};
KW   ATP-binding {ECO:0000256|PIRNR:PIRNR001327};
KW   Nucleotide-binding {ECO:0000256|PIRNR:PIRNR001327};
KW   Reference proteome {ECO:0000313|Proteomes:UP000189177};
KW   Translocase {ECO:0000256|PIRNR:PIRNR001327}.
FT   DOMAIN          8..238
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
FT   DOMAIN          332..525
FT                   /note="AAA+ ATPase"
FT                   /evidence="ECO:0000259|SMART:SM00382"
SQ   SEQUENCE   598 AA;  64278 MW;  E3A05FDE6CE7F591 CRC64;
     MMRFLDDAPR YLFFTGKGGV GKTSIACASA IRLAEAGRRV LLVSTDPASN VDQVFGVSIG
     NRVTPVADVP GLSALEIDPQ AAAEAYRDKI VGPVKGVLPD TVVAGIEEQL SGACTTEIAA
     FDEFTELLTG SDLVKGFDHV VFDTAPTGHT IRLLQLPGAW SGFLEKGQGD ASCLGPLAGL
     EKQKERYRAA VDALASPDAT RLVLVARAQS GSLDEVARTH DELAEIGLQR QYLVVNGRMP
     EAETRGDDLA RGILERERAA LEAMAPVLQA LPRDDIELKP FNLVGLDRLR QLFGTPESAT
     AAVPGDDMAG EDTAQLEAPS LSELVDDIAT DGKGLVMLMG KGGVGKTTLA AAVAVSLARR
     GFPVHLTTSD PAAHLSETLS DEVENLTVSR IDPTVETERY REQVLQSKGK DMNEEDRALL
     EEDLRSPCTE EIAVFQAFSR VIREAGRKFV VMDTAPTGHT LLLLDATGAY HREIVRQMGD
     TGTHYTTPMM QLQDPQRTKM LLVTLAETTP VLEARDLQED LRRAGIEPWA WVVNNSIAAA
     GAASGLLRDR ARAERPQIRA VAEEHAARYA VVPLLRDEPV GAERLLALTE ITASQATA
//