ID A0A1V3TUR5_9PAST Unreviewed; 300 AA.
AC A0A1V3TUR5;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE RecName: Full=Tyrosine recombinase XerC {ECO:0000256|ARBA:ARBA00015804, ECO:0000256|HAMAP-Rule:MF_01808};
GN Name=xerC {ECO:0000256|HAMAP-Rule:MF_01808};
GN ORFNames=BMT54_04095 {ECO:0000313|EMBL:OOH90622.1};
OS Pasteurellaceae bacterium 15-036681.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae.
OX NCBI_TaxID=1924934 {ECO:0000313|EMBL:OOH90622.1, ECO:0000313|Proteomes:UP000188845};
RN [1] {ECO:0000313|EMBL:OOH90622.1, ECO:0000313|Proteomes:UP000188845}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=15-036681 {ECO:0000313|EMBL:OOH90622.1,
RC ECO:0000313|Proteomes:UP000188845};
RA Stuber T.P., Hicks J.A., Robbe-Austerman S., Lantz K.;
RT "Draft genome sequence of a Pasteurellaceae bacterium isolated from a pygmy
RT hippo (Hexaprotodon liberiensis).";
RL Submitted (NOV-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Site-specific tyrosine recombinase, which acts by catalyzing
CC the cutting and rejoining of the recombining DNA molecules. The XerC-
CC XerD complex is essential to convert dimers of the bacterial chromosome
CC into monomers to permit their segregation at cell division. It also
CC contributes to the segregational stability of plasmids.
CC {ECO:0000256|HAMAP-Rule:MF_01808}.
CC -!- SUBUNIT: Forms a cyclic heterotetrameric complex composed of two
CC molecules of XerC and two molecules of XerD. {ECO:0000256|HAMAP-
CC Rule:MF_01808}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496,
CC ECO:0000256|HAMAP-Rule:MF_01808}.
CC -!- SIMILARITY: Belongs to the 'phage' integrase family. XerC subfamily.
CC {ECO:0000256|ARBA:ARBA00006657, ECO:0000256|HAMAP-Rule:MF_01808}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OOH90622.1}.
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DR EMBL; MQVI01000010; OOH90622.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V3TUR5; -.
DR STRING; 1924934.BMT54_04095; -.
DR OrthoDB; 9801717at2; -.
DR Proteomes; UP000188845; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR GO; GO:0009037; F:tyrosine-based site-specific recombinase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0051301; P:cell division; IEA:UniProtKB-KW.
DR GO; GO:0007059; P:chromosome segregation; IEA:UniProtKB-UniRule.
DR GO; GO:0006313; P:DNA transposition; IEA:UniProtKB-UniRule.
DR CDD; cd00798; INT_XerDC_C; 1.
DR Gene3D; 1.10.150.130; -; 1.
DR Gene3D; 1.10.443.10; Intergrase catalytic core; 1.
DR HAMAP; MF_01808; Recomb_XerC_XerD; 1.
DR InterPro; IPR044068; CB.
DR InterPro; IPR011010; DNA_brk_join_enz.
DR InterPro; IPR013762; Integrase-like_cat_sf.
DR InterPro; IPR002104; Integrase_catalytic.
DR InterPro; IPR010998; Integrase_recombinase_N.
DR InterPro; IPR004107; Integrase_SAM-like_N.
DR InterPro; IPR011931; Recomb_XerC.
DR InterPro; IPR023009; Tyrosine_recombinase_XerC/XerD.
DR NCBIfam; TIGR02224; recomb_XerC; 1.
DR PANTHER; PTHR30349; PHAGE INTEGRASE-RELATED; 1.
DR PANTHER; PTHR30349:SF85; TYROSINE RECOMBINASE XERC; 1.
DR Pfam; PF02899; Phage_int_SAM_1; 1.
DR Pfam; PF00589; Phage_integrase; 1.
DR SUPFAM; SSF56349; DNA breaking-rejoining enzymes; 1.
DR SUPFAM; SSF47823; lambda integrase-like, N-terminal domain; 1.
DR PROSITE; PS51900; CB; 1.
DR PROSITE; PS51898; TYR_RECOMBINASE; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306, ECO:0000256|HAMAP-
KW Rule:MF_01808};
KW Cell division {ECO:0000256|ARBA:ARBA00022618, ECO:0000256|HAMAP-
KW Rule:MF_01808};
KW Chromosome partition {ECO:0000256|ARBA:ARBA00022829, ECO:0000256|HAMAP-
KW Rule:MF_01808};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_01808};
KW DNA integration {ECO:0000256|ARBA:ARBA00022908, ECO:0000256|HAMAP-
KW Rule:MF_01808};
KW DNA recombination {ECO:0000256|ARBA:ARBA00023172, ECO:0000256|HAMAP-
KW Rule:MF_01808};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|HAMAP-
KW Rule:MF_01808}; Reference proteome {ECO:0000313|Proteomes:UP000188845}.
FT DOMAIN 3..89
FT /note="Core-binding (CB)"
FT /evidence="ECO:0000259|PROSITE:PS51900"
FT DOMAIN 110..289
FT /note="Tyr recombinase"
FT /evidence="ECO:0000259|PROSITE:PS51898"
FT ACT_SITE 149
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808"
FT ACT_SITE 173
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808"
FT ACT_SITE 241
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808"
FT ACT_SITE 244
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808"
FT ACT_SITE 267
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808"
FT ACT_SITE 276
FT /note="O-(3'-phospho-DNA)-tyrosine intermediate"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01808"
SQ SEQUENCE 300 AA; 34187 MW; 2136E1491AB548E7 CRC64;
MPHSLYSHTQ PYWDFLRIEK QASPHTLSNY QRQVKAVCEM LAQAEISNWQ DVDASTVRWL
LSQSHKQGLS AKSIGLRLVA LRQFLDFLVR QGKLTVNPTI GIKSPKANKH LPKNIDAEQV
AQLLNIESNQ PLDLRDIAMM ELMYSSGLRL SELQGLDLGD MDLNSQEVRI LGKGNKERIV
PIGSKAVEAI NNWLAVRAEF KPQDNALFLN QRGGRLSHRS IQLAMKKWGQ KQHLDTHLHP
HKLRHSFATH MLEASADLRA VQELLGHSSL STTQIYTHLD FQHLAKIYDS AHPRARRKKE
//
