ID A0A1V3ZY12_9ACTN Unreviewed; 793 AA.
AC A0A1V3ZY12;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Polyketide synthase {ECO:0000313|EMBL:OON69570.1};
DE Flags: Fragment;
GN ORFNames=B1H18_34715 {ECO:0000313|EMBL:OON69570.1};
OS Streptomyces tsukubensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=83656 {ECO:0000313|EMBL:OON69570.1, ECO:0000313|Proteomes:UP000190539};
RN [1] {ECO:0000313|EMBL:OON69570.1, ECO:0000313|Proteomes:UP000190539}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F601 {ECO:0000313|EMBL:OON69570.1,
RC ECO:0000313|Proteomes:UP000190539};
RA Zong G., Zhong C., Fu J., Qin R., Cao G.;
RT "Draft Genome Sequence of Streptomyces tsukubaensis F601, a Producer of the
RT immunosuppressant tacrolimus FK506.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OON69570.1}.
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DR EMBL; MVFC01000089; OON69570.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V3ZY12; -.
DR STRING; 83656.B1H18_34715; -.
DR Proteomes; UP000190539; Unassembled WGS sequence.
DR GO; GO:0004315; F:3-oxoacyl-[acyl-carrier-protein] synthase activity; IEA:InterPro.
DR GO; GO:0031177; F:phosphopantetheine binding; IEA:InterPro.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:1901362; P:organic cyclic compound biosynthetic process; IEA:UniProt.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.30.70.3290; -; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 1.10.1200.10; ACP-like; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR036736; ACP-like_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR018201; Ketoacyl_synth_AS.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR020806; PKS_PP-bd.
DR InterPro; IPR009081; PP-bd_ACP.
DR InterPro; IPR006162; Ppantetheine_attach_site.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR Pfam; PF00550; PP-binding; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SMART; SM00823; PKS_PP; 1.
DR SMART; SM01294; PKS_PP_betabranch; 1.
DR SUPFAM; SSF47336; ACP-like; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS50075; CARRIER; 1.
DR PROSITE; PS00606; KS3_1; 1.
DR PROSITE; PS52004; KS3_2; 1.
DR PROSITE; PS00012; PHOSPHOPANTETHEINE; 1.
PE 4: Predicted;
KW Acyltransferase {ECO:0000256|ARBA:ARBA00023315};
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Phosphopantetheine {ECO:0000256|ARBA:ARBA00022450};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000190539};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 98..173
FT /note="Carrier"
FT /evidence="ECO:0000259|PROSITE:PS50075"
FT DOMAIN 190..609
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT REGION 608..660
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 619..633
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT NON_TER 793
FT /evidence="ECO:0000313|EMBL:OON69570.1"
SQ SEQUENCE 793 AA; 82344 MW; 2F5762615BDE7856 CRC64;
MWQTTSTLTQ HLTTTERDRI RRGGFLPISD EEGMRLYDAA VGSGEAFVMA AAMDLSQPMA
GDVPPILSGL RRSARRTARA GQTFTQRLAE LPAADRDTAL VTLVSDATAT VLGHADASAI
APTTTFKDLG IDSLTAIELR NRLAEATGLR LSATMVFDHP TPRVLAAELR TDLFGTAVPL
PARTTRARDD EPLAIVGMAC RLPGGVTSPE ELWRLVESGT DAITEFPDDR GWDIDRMFDP
DPDAPGKTYV RHGGFLSEAA GFDAAFFGIS PREAWAMDPQ QRVILETVWE AFENAGIVPD
TLRGSDTGVF MGAFSHGYGA GVDLGGFGAT ATQNSVLSGR LSYFFGMEGP AVTIDTACSS
SMVALHQAAQ SLRDGECSLA LAGGVTVMPT PLGYVEFCRQ RGLAPDGRAK AFAEGADGTS
FSEGSGVLVV ERLSDAERNG HTVLALVRSS AVNQDGASNG ISAPNGPSQQ RVIRQALDKA
GLTPADIDVV EAHGTGTPLG DPIEAQAIIA TYGQDRDTPL YLGSVKSNIG HTQTTAGLAG
VIKMVMAMRH GVLPKTLHVD EPSSHVDWSA GAVELLTEAR PWPGSGRPRR AGVSSLGISG
TNAHVILEGV EGPPSGLGPS SPTGASSGAE PSAGAESSGL GAGSPGAGAD ADRGLGPVPL
PVSARTESSL ASLVERLDAY VRGGLSVGGD LGGVADGLVR GRAVFGHRAV LLGESRVAGV
AVDGLRTVFV FPGQGSQWTG MGVELMSASE VFAARMAECA AALEPFTGWD VRDMLADSAV
LERVEVLQPA SWA
//