ID A0A1V3ZY43_9ACTN Unreviewed; 214 AA.
AC A0A1V3ZY43;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 14.
DE RecName: Full=Ketoreductase (KR) domain-containing protein {ECO:0000259|Pfam:PF08659};
DE Flags: Fragment;
GN ORFNames=B1H18_34865 {ECO:0000313|EMBL:OON67685.1};
OS Streptomyces tsukubensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=83656 {ECO:0000313|EMBL:OON67685.1, ECO:0000313|Proteomes:UP000190539};
RN [1] {ECO:0000313|EMBL:OON67685.1, ECO:0000313|Proteomes:UP000190539}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F601 {ECO:0000313|EMBL:OON67685.1,
RC ECO:0000313|Proteomes:UP000190539};
RA Zong G., Zhong C., Fu J., Qin R., Cao G.;
RT "Draft Genome Sequence of Streptomyces tsukubaensis F601, a Producer of the
RT immunosuppressant tacrolimus FK506.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OON67685.1}.
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DR EMBL; MVFC01000117; OON67685.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V3ZY43; -.
DR STRING; 83656.B1H18_34865; -.
DR Proteomes; UP000190539; Unassembled WGS sequence.
DR CDD; cd08956; KR_3_FAS_SDR_x; 1.
DR Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR InterPro; IPR013968; PKS_KR.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF08659; KR; 1.
DR SMART; SM00822; PKS_KR; 1.
DR SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000190539}.
FT DOMAIN 2..154
FT /note="Ketoreductase (KR)"
FT /evidence="ECO:0000259|Pfam:PF08659"
FT NON_TER 214
FT /evidence="ECO:0000313|EMBL:OON67685.1"
SQ SEQUENCE 214 AA; 21663 MW; 60AD9A36FF4A3104 CRC64;
MRDVVLVSRG GAAAVGAVEL REELVGLGAG VRVVACDVGD RASVVELLEG VCREGRLTGV
VHAAGVLDDG VLESLSVERV ERVLRPKVDG AVFLHELTLG MDLSAFVLFS SVAGVLGNAG
QGNYAAANAF LDALAQRRRA GGLPGVSLAW GLWGRRGGLT GGLGAVDVAR LGRSGILPMG
TGEALGLFDV ALGGERALVV PVRFDRAAAS AGVG
//
