ID A0A1V4A1N9_9ACTN Unreviewed; 547 AA.
AC A0A1V4A1N9;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=Ketosynthase family 3 (KS3) domain-containing protein {ECO:0000259|PROSITE:PS52004};
DE Flags: Fragment;
GN ORFNames=B1H18_29635 {ECO:0000313|EMBL:OON72402.1};
OS Streptomyces tsukubensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=83656 {ECO:0000313|EMBL:OON72402.1, ECO:0000313|Proteomes:UP000190539};
RN [1] {ECO:0000313|EMBL:OON72402.1, ECO:0000313|Proteomes:UP000190539}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F601 {ECO:0000313|EMBL:OON72402.1,
RC ECO:0000313|Proteomes:UP000190539};
RA Zong G., Zhong C., Fu J., Qin R., Cao G.;
RT "Draft Genome Sequence of Streptomyces tsukubaensis F601, a Producer of the
RT immunosuppressant tacrolimus FK506.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pantetheine 4'-phosphate; Xref=ChEBI:CHEBI:47942;
CC Evidence={ECO:0000256|ARBA:ARBA00001957};
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OON72402.1}.
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DR EMBL; MVFC01000038; OON72402.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4A1N9; -.
DR STRING; 83656.B1H18_29635; -.
DR Proteomes; UP000190539; Unassembled WGS sequence.
DR GO; GO:0016747; F:acyltransferase activity, transferring groups other than amino-acyl groups; IEA:UniProt.
DR GO; GO:0017000; P:antibiotic biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00833; PKS; 1.
DR Gene3D; 3.40.47.10; -; 1.
DR Gene3D; 3.40.366.10; Malonyl-Coenzyme A Acyl Carrier Protein, domain 2; 1.
DR InterPro; IPR001227; Ac_transferase_dom_sf.
DR InterPro; IPR014043; Acyl_transferase.
DR InterPro; IPR016035; Acyl_Trfase/lysoPLipase.
DR InterPro; IPR014031; Ketoacyl_synth_C.
DR InterPro; IPR014030; Ketoacyl_synth_N.
DR InterPro; IPR032821; PKS_assoc.
DR InterPro; IPR020841; PKS_Beta-ketoAc_synthase_dom.
DR InterPro; IPR016039; Thiolase-like.
DR PANTHER; PTHR43775; FATTY ACID SYNTHASE; 1.
DR PANTHER; PTHR43775:SF51; PHENOLPHTHIOCEROL_PHTHIOCEROL POLYKETIDE SYNTHASE SUBUNIT E; 1.
DR Pfam; PF00698; Acyl_transf_1; 1.
DR Pfam; PF16197; KAsynt_C_assoc; 1.
DR Pfam; PF00109; ketoacyl-synt; 1.
DR Pfam; PF02801; Ketoacyl-synt_C; 1.
DR SMART; SM00825; PKS_KS; 1.
DR SUPFAM; SSF52151; FabD/lysophospholipase-like; 1.
DR SUPFAM; SSF53901; Thiolase-like; 1.
DR PROSITE; PS52004; KS3_2; 1.
PE 4: Predicted;
KW Antibiotic biosynthesis {ECO:0000256|ARBA:ARBA00023194};
KW Reference proteome {ECO:0000313|Proteomes:UP000190539}.
FT DOMAIN 1..388
FT /note="Ketosynthase family 3 (KS3)"
FT /evidence="ECO:0000259|PROSITE:PS52004"
FT NON_TER 547
FT /evidence="ECO:0000313|EMBL:OON72402.1"
SQ SEQUENCE 547 AA; 56323 MW; 9B77ABF1CFEDAE3B CRC64;
MPDGRWDNTF LHALQESESQ TVRRGAFLDD VAGFDAAFFN VSPREAAMMD PQQRLLLELS
WEAIEDAGIR AEQLPEAHTG VFVGVGGDDY SSLIREQGPD GISPHTFTGS LRSIIANRVS
YFLRATGPSL VVDAGQASSL VALHLAADSL RKGDSDIAIA GGVTLRLTPH HSLAAHRFGA
LSPDGQCHVF DARANGFAQG EGGGAVVLKR LQDAVAAGDE IYCVIRGSAV NNDGGGAQLA
EPSARAQAAV IREAHRLAGS DPRDVAYVEL HGTGTKAGDP VEAAALAEAI GSVRQAGSPL
RVGSIKSNIG HLEAAAGIAG FIKTALCVRS GTLVPTVGFR TPNPRIPLDE LNLHVQTSVE
EVELDESALF GVSSFGVGGT NCHMVVSAAP AAAGVAGRGG SAPLASGLDT SPSTPLVGTR
DVPVPFVLSA TSAVALRGQA ARLSESLRTD DRPANAVNLG WSLLTTRTAW SHRAVVMGAV
GADVSAAGEG LAALAAGEPS ELVRTGRTVP PVKPVFVYPG QGSQWLGMAT DLIDTSPAFA
TALQQCA
//
