ID   A0A1V4A5L1_9ACTN        Unreviewed;       339 AA.
AC   A0A1V4A5L1;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 18.
DE   SubName: Full=NADP-dependent oxidoreductase {ECO:0000313|EMBL:OON76649.1};
GN   ORFNames=B1H18_20190 {ECO:0000313|EMBL:OON76649.1};
OS   Streptomyces tsukubensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=83656 {ECO:0000313|EMBL:OON76649.1, ECO:0000313|Proteomes:UP000190539};
RN   [1] {ECO:0000313|EMBL:OON76649.1, ECO:0000313|Proteomes:UP000190539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F601 {ECO:0000313|EMBL:OON76649.1,
RC   ECO:0000313|Proteomes:UP000190539};
RA   Zong G., Zhong C., Fu J., Qin R., Cao G.;
RT   "Draft Genome Sequence of Streptomyces tsukubaensis F601, a Producer of the
RT   immunosuppressant tacrolimus FK506.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OON76649.1}.
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DR   EMBL; MVFC01000017; OON76649.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V4A5L1; -.
DR   STRING; 83656.B1H18_20190; -.
DR   OrthoDB; 9805663at2; -.
DR   Proteomes; UP000190539; Unassembled WGS sequence.
DR   GO; GO:0016628; F:oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor; IEA:InterPro.
DR   CDD; cd05288; PGDH; 1.
DR   Gene3D; 3.90.180.10; Medium-chain alcohol dehydrogenases, catalytic domain; 1.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR013149; ADH-like_C.
DR   InterPro; IPR041694; ADH_N_2.
DR   InterPro; IPR011032; GroES-like_sf.
DR   InterPro; IPR045010; MDR_fam.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR020843; PKS_ER.
DR   PANTHER; PTHR43205; PROSTAGLANDIN REDUCTASE; 1.
DR   PANTHER; PTHR43205:SF7; PROSTAGLANDIN REDUCTASE 1; 1.
DR   Pfam; PF16884; ADH_N_2; 1.
DR   Pfam; PF00107; ADH_zinc_N; 1.
DR   SMART; SM00829; PKS_ER; 1.
DR   SUPFAM; SSF50129; GroES-like; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Oxidoreductase {ECO:0000256|ARBA:ARBA00023002};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190539}.
FT   DOMAIN          21..335
FT                   /note="Enoyl reductase (ER)"
FT                   /evidence="ECO:0000259|SMART:SM00829"
FT   REGION          1..23
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        9..23
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   339 AA;  36576 MW;  F08AAF0C28695E17 CRC64;
     MSALPETGRE WHLVRRPDGE PVPDDFALRE RPVGQPSEGH VLVKNLYFSV DPYMRGRMDD
     VKSYTPPFQL DQPMAGGAVG QVVASQADGF SEGDYVLHFG GWREYASVPA KHLTKVDPDA
     APLSAYLGVL GMTGLTAYSG LLRVAEFKEG DAVFVSGAAG AVGSEVGQIA RLKGASRVIG
     SAGSDEKVKF LTEELGFDAA FNYKNGPVAD QLREAAPAGI DVYFDNVGGD HLEAAISRLN
     THGRIAVCGM ISQYNSTKPT SAPRNLALLI GKRLRMEGML VQDHADLQGQ FIEDVSRWVR
     SGDLKYRETV VRGVDNGVEA FLGLMRGENT GKMIVDLTD
//