ID A0A1V4A8I0_9ACTN Unreviewed; 1335 AA.
AC A0A1V4A8I0;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 19.
DE SubName: Full=Secretion protein EccC {ECO:0000313|EMBL:OON78072.1};
GN ORFNames=B1H18_17830 {ECO:0000313|EMBL:OON78072.1};
OS Streptomyces tsukubensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=83656 {ECO:0000313|EMBL:OON78072.1, ECO:0000313|Proteomes:UP000190539};
RN [1] {ECO:0000313|EMBL:OON78072.1, ECO:0000313|Proteomes:UP000190539}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F601 {ECO:0000313|EMBL:OON78072.1,
RC ECO:0000313|Proteomes:UP000190539};
RA Zong G., Zhong C., Fu J., Qin R., Cao G.;
RT "Draft Genome Sequence of Streptomyces tsukubaensis F601, a Producer of the
RT immunosuppressant tacrolimus FK506.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OON78072.1}.
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DR EMBL; MVFC01000013; OON78072.1; -; Genomic_DNA.
DR STRING; 83656.B1H18_17830; -.
DR Proteomes; UP000190539; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 4.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR023836; EccCa-like_Actinobacteria.
DR InterPro; IPR023837; EccCb-like_Actinobacteria.
DR InterPro; IPR002543; FtsK_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR NCBIfam; TIGR03924; T7SS_EccC_a; 1.
DR NCBIfam; TIGR03925; T7SS_EccC_b; 1.
DR PANTHER; PTHR22683; SPORULATION PROTEIN RELATED; 1.
DR PANTHER; PTHR22683:SF1; TYPE VII SECRETION SYSTEM PROTEIN ESSC; 1.
DR Pfam; PF01580; FtsK_SpoIIIE; 3.
DR SMART; SM00382; AAA; 3.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 3.
DR PROSITE; PS50901; FTSK; 3.
PE 4: Predicted;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Membrane {ECO:0000256|SAM:Phobius};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00289}; Reference proteome {ECO:0000313|Proteomes:UP000190539};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 24..43
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 50..72
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 470..670
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT DOMAIN 825..1016
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT DOMAIN 1114..1298
FT /note="FtsK"
FT /evidence="ECO:0000259|PROSITE:PS50901"
FT REGION 204..233
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT BINDING 493..500
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
FT BINDING 843..850
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
FT BINDING 1131..1138
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00289"
SQ SEQUENCE 1335 AA; 145926 MW; E4574BAAAC5443DD CRC64;
MPEGQLTLQE PPVLAEVVPD TSAIWTYLPM ALMSVSMMLM FLRPGGGNGV FMYLAMGVMA
LSAGAMLLGQ LMRRSSERKQ RLKGERRDYL RYLAQTRKRV RVTIAEQQRA LAWRHPDPGS
LRSLARTSRL WERRPSDEDF GEVRIAKGEQ QLALSLEPVS TRPVEDLEPL CAHALRRFIR
AYSTIPEQPL GLYLRSSARI LLRPEGTPDG DQAASGPPPT GEGGVGQDQG PGAEAVRSLA
RAVLGQLAVF HAPEELWIAL CVSDERRADW EWVKWLPHAL DPHEEDGAGQ ARRITSDLTE
LDDLLGADFA ERPGFDPDAR PGRDEPYTIV VLDGVTVPPG HRWEGHGYRN ALALDVSGAL
RWRPGRNMLR LTVGPELVSL VRTDRSRKVR SVPLGRPDRL GPLGAEALAR LLSPRRVSLS
TDIAQPLDTD VELTTLLGIP DLHRHAPEVL FDRHTGSGRL RVPIAVGVDG RPVELDIKES
AQGGMGPHGM LIGATGSGKS ELLRTLVLGL ALTNSSEVLN FILVDFKGGA TFLGLEELPH
TSAVITNLAD EVALVERMQD ALHGELIRRQ ELLRSAGNHT SALEYERARA AGAPLAPLPS
LFVVVDEFSE LLSAHREFMD LFVMIGRLGR SLGVHLLLAS QRLDEGRMHQ LESHLSYRIG
LRTFSAMESR GVLGVPNAYE LPAQPGSGYL KSGVESLTRF RAAYSSGMYR RRTGAVIRAR
VASQVVPWST DWVVPRAPAP APEPETEESG DEETLLDVAL DRLRGSGPAA HQVWLPPLAE
PSPLDVLLPG IAPHPERGLT AVGRSGTGRL RVPVGLVDKP FDQRRDPLVV DLSGAGGHIA
VAGGSQSGKS TLVRTLIAAL ALTHTPAEVQ FYCLDFGGGG LSQLAALPHV GGVAPRLNPE
RVQRAVAEVM TLLAHREQFF VDHTIDSMQS YRRRRAAGEF ADEPFGDVFM VVDGWSTVRQ
DYDDLIQKFN ELAARGLNYG IHLLISTTRW VELSAQVRDQ AATRLELRMG DPMDSEIDTR
KARSVPRSGG RGITADSKMH FLAGLPRLDG SSSLDDLGDG VAHLVAEVAR HWPGAPAPQV
RMLPHRLPLT ELPAPEATEG DGLRIPLGID QDALEPVWHD FSRTPHLIVV GDTESGKTNL
LRAIARSITT RYTPDRAKII AVDYRRTLVD AVPEEYRIGH VISLDNLNET IEGAARAMKD
RVPGADIAPA RMRQCDWWTG PRLFILVDDY DMVAGSTFQG PFEPLFGNLA LGFEMGLHLV
IARSAMGAGR GLSDGLVRRL DEANNPAVLL SCPPTEGRLF GNTKPLNLPP GRAQHIARRR
ARLMQTALVE EAQEQ
//
