ID   A0A1V4AC76_9ACTN        Unreviewed;       277 AA.
AC   A0A1V4AC76;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 15.
DE   SubName: Full=MBL fold metallo-hydrolase {ECO:0000313|EMBL:OON81030.1};
GN   ORFNames=B1H18_09415 {ECO:0000313|EMBL:OON81030.1};
OS   Streptomyces tsukubensis.
OC   Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC   Streptomycetaceae; Streptomyces.
OX   NCBI_TaxID=83656 {ECO:0000313|EMBL:OON81030.1, ECO:0000313|Proteomes:UP000190539};
RN   [1] {ECO:0000313|EMBL:OON81030.1, ECO:0000313|Proteomes:UP000190539}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=F601 {ECO:0000313|EMBL:OON81030.1,
RC   ECO:0000313|Proteomes:UP000190539};
RA   Zong G., Zhong C., Fu J., Qin R., Cao G.;
RT   "Draft Genome Sequence of Streptomyces tsukubaensis F601, a Producer of the
RT   immunosuppressant tacrolimus FK506.";
RL   Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OON81030.1}.
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DR   EMBL; MVFC01000005; OON81030.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V4AC76; -.
DR   STRING; 83656.B1H18_09415; -.
DR   OrthoDB; 9788263at2; -.
DR   Proteomes; UP000190539; Unassembled WGS sequence.
DR   GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR   GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR   CDD; cd16278; metallo-hydrolase-like_MBL-fold; 1.
DR   Gene3D; 3.60.15.10; Ribonuclease Z/Hydroxyacylglutathione hydrolase-like; 1.
DR   Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR   InterPro; IPR041516; LACTB2_WH.
DR   InterPro; IPR001279; Metallo-B-lactamas.
DR   InterPro; IPR036866; RibonucZ/Hydroxyglut_hydro.
DR   InterPro; IPR036388; WH-like_DNA-bd_sf.
DR   PANTHER; PTHR23131; ENDORIBONUCLEASE LACTB2; 1.
DR   PANTHER; PTHR23131:SF0; ENDORIBONUCLEASE LACTB2; 1.
DR   Pfam; PF17778; BLACT_WH; 1.
DR   Pfam; PF00753; Lactamase_B; 1.
DR   SMART; SM00849; Lactamase_B; 1.
DR   SUPFAM; SSF56281; Metallo-hydrolase/oxidoreductase; 1.
PE   4: Predicted;
KW   Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000313|EMBL:OON81030.1};
KW   Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190539}.
FT   DOMAIN          39..204
FT                   /note="Metallo-beta-lactamase"
FT                   /evidence="ECO:0000259|SMART:SM00849"
SQ   SEQUENCE   277 AA;  28902 MW;  F1415664CDFB2DBB CRC64;
     MTDAASLPGR PRGAVVSGPA TARAVNVLAP NASAMTLDGT NTWIVAEPDS GLAVVIDPGP
     LDEGHLKKVM DTAESAGNRV ALTLLTHGHP DHAEGASRFA ELTGTAVRAL DPALRLGDEG
     LAAGDVVTVG GLELRVVPTP GHTSDSLCFH LPADQAVLTG DTVLGRGTTV VAHPDGRLGD
     YLDSLRRLRS LTVDDGVRTV LPGHGPVLED AQGVVEYYLA HRAKRLAQVE TAVENGCTTA
     HEVVARVYAD VDHALWPAAE WSVAAQLEYL REHGLIG
//