ID A0A1V4AD64_9ACTN Unreviewed; 957 AA.
AC A0A1V4AD64;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE SubName: Full=Haloacid dehalogenase {ECO:0000313|EMBL:OON81347.1};
GN ORFNames=B1H18_08380 {ECO:0000313|EMBL:OON81347.1};
OS Streptomyces tsukubensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=83656 {ECO:0000313|EMBL:OON81347.1, ECO:0000313|Proteomes:UP000190539};
RN [1] {ECO:0000313|EMBL:OON81347.1, ECO:0000313|Proteomes:UP000190539}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F601 {ECO:0000313|EMBL:OON81347.1,
RC ECO:0000313|Proteomes:UP000190539};
RA Zong G., Zhong C., Fu J., Qin R., Cao G.;
RT "Draft Genome Sequence of Streptomyces tsukubaensis F601, a Producer of the
RT immunosuppressant tacrolimus FK506.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OON81347.1}.
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DR EMBL; MVFC01000004; OON81347.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4AD64; -.
DR STRING; 83656.B1H18_08380; -.
DR Proteomes; UP000190539; Unassembled WGS sequence.
DR GO; GO:0030246; F:carbohydrate binding; IEA:InterPro.
DR GO; GO:0016798; F:hydrolase activity, acting on glycosyl bonds; IEA:UniProtKB-KW.
DR GO; GO:0005975; P:carbohydrate metabolic process; IEA:InterPro.
DR Gene3D; 1.50.10.10; -; 1.
DR Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR Gene3D; 2.70.98.40; Glycoside hydrolase, family 65, N-terminal domain; 1.
DR InterPro; IPR008928; 6-hairpin_glycosidase_sf.
DR InterPro; IPR012341; 6hp_glycosidase-like_sf.
DR InterPro; IPR000421; FA58C.
DR InterPro; IPR011013; Gal_mutarotase_sf_dom.
DR InterPro; IPR008979; Galactose-bd-like_sf.
DR InterPro; IPR005194; Glyco_hydro_65_C.
DR InterPro; IPR005195; Glyco_hydro_65_M.
DR InterPro; IPR005196; Glyco_hydro_65_N.
DR InterPro; IPR037018; Glyco_hydro_65_N_sf.
DR PANTHER; PTHR11051; GLYCOSYL HYDROLASE-RELATED; 1.
DR PANTHER; PTHR11051:SF8; PROTEIN-GLUCOSYLGALACTOSYLHYDROXYLYSINE GLUCOSIDASE; 1.
DR Pfam; PF00754; F5_F8_type_C; 1.
DR Pfam; PF03633; Glyco_hydro_65C; 1.
DR Pfam; PF03632; Glyco_hydro_65m; 1.
DR Pfam; PF03636; Glyco_hydro_65N; 1.
DR SUPFAM; SSF74650; Galactose mutarotase-like; 1.
DR SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR SUPFAM; SSF48208; Six-hairpin glycosidases; 1.
PE 4: Predicted;
KW Glycosidase {ECO:0000256|ARBA:ARBA00023295};
KW Hydrolase {ECO:0000256|ARBA:ARBA00023295};
KW Reference proteome {ECO:0000313|Proteomes:UP000190539};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..957
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012957277"
FT DOMAIN 65..353
FT /note="Glycoside hydrolase family 65 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF03636"
FT DOMAIN 414..637
FT /note="Glycoside hydrolase family 65 central catalytic"
FT /evidence="ECO:0000259|Pfam:PF03632"
FT DOMAIN 757..816
FT /note="Glycoside hydrolase family 65 C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03633"
FT DOMAIN 848..941
FT /note="F5/8 type C"
FT /evidence="ECO:0000259|Pfam:PF00754"
FT REGION 22..57
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 243..330
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 937..957
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 243..302
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 957 AA; 101889 MW; 6902A464885B026E CRC64;
MRTGVLVAVL FTALVGAAAA PGVATPGRGE DVGPPIGPSD PASCAPSPGW APSAHHRTES
GTFHAYTGNG YLGTRVPPSG GGYAETGGRT GWPLFTPGYD GAFVSGLYGR GPEVTAGRQV
LAALPSWTGL DLTVDGETYG AVTPQARISH YRQTLFLRCG FVRTSLTWAT ADGRRTDLVL
DVLTSRDDPH TGAVRLRMTP HWDGRATVTD RIDGRGARRL IPAKARDIGG GGPGTVTIPF
RTTSAPLKAN KARQTNKAKQ TQEATNKAMK AQEAQESKQT QKTRSATRKA QKGETGALSS
TLRAPGRTAG PMTEAGGPTT RAGTSLSARQ SSTFAVRAGR TYEAAKYVGV DTSLTARSPV
AAATAASLRA ADRGWPALFA AHTAAWRALW SSDVEVPGRP DLQLWSRASQ YGLLSATRKG
SGDSVGPAGL SSDNYAGLIF WDAETWMFPA LLATRPELAR TVLEYRYRTR SAARANAHKL
GFQGLFYPWT SAGHGEIWSE CHSWRPPHCV TQNHLQSDIA LAAWQYWLTT GDKAWLRERG
WPLLKGIAEF WADRATRNPD GSYSVDEVAG PDEYSNGVDD GVFTNAGAAT ALRDASLAAR
ALGRTAPDAW QTVADGLRIP YDPKRKIFLQ YAGYADTKIK QADTVMLLYP LEWPMPAGAA
AATLDHYAAL TDPEGPAMTD SVHAVDAAAI GEPGCATYTY LQRSIRPFVR GPFGLFSEAR
GDKAGADDPL SGMPAQDFVT GKGGFLQVFT HGLTGSRPRQ GAVHLDPTLP PQLRRGVTVR
GLRLHSSTYD IAIGPATTRV TLTGGPPFKV ESPDRRERFT VDASSPAVLR TRRPDLAPTS
NAARCRPVSA TSEEPGLYAE AAVDGSTTTA WSPAADRASL TVDMGAPARR FRAVTPKWGV
APASYSVETS TDRHTWTEAP DNAPTQPARY VRLTVRTSGP KGPAPALREV TVTAPVQ
//
