ID A0A1V4ADT0_9ACTN Unreviewed; 560 AA.
AC A0A1V4ADT0;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=AMP-dependent synthetase {ECO:0000313|EMBL:OON81910.1};
GN ORFNames=B1H18_05555 {ECO:0000313|EMBL:OON81910.1};
OS Streptomyces tsukubensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=83656 {ECO:0000313|EMBL:OON81910.1, ECO:0000313|Proteomes:UP000190539};
RN [1] {ECO:0000313|EMBL:OON81910.1, ECO:0000313|Proteomes:UP000190539}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F601 {ECO:0000313|EMBL:OON81910.1,
RC ECO:0000313|Proteomes:UP000190539};
RA Zong G., Zhong C., Fu J., Qin R., Cao G.;
RT "Draft Genome Sequence of Streptomyces tsukubaensis F601, a Producer of the
RT immunosuppressant tacrolimus FK506.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the ATP-dependent AMP-binding enzyme family.
CC {ECO:0000256|ARBA:ARBA00006432}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OON81910.1}.
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DR EMBL; MVFC01000003; OON81910.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4ADT0; -.
DR STRING; 83656.B1H18_05555; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000190539; Unassembled WGS sequence.
DR GO; GO:0016878; F:acid-thiol ligase activity; IEA:UniProt.
DR GO; GO:0016405; F:CoA-ligase activity; IEA:UniProt.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43605:SF10; ACYL-COA SYNTHETASE MEDIUM CHAIN FAMILY MEMBER 3; 1.
DR PANTHER; PTHR43605; ACYL-COENZYME A SYNTHETASE; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
PE 3: Inferred from homology;
KW Ligase {ECO:0000256|ARBA:ARBA00022598};
KW Reference proteome {ECO:0000313|Proteomes:UP000190539}.
FT DOMAIN 55..408
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 459..536
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 560 AA; 62074 MW; 755E4EEE3DE72DA0 CRC64;
MRAEAPATEE FRAARDFLLG HSDDYAAAYE GFAWPRPEYF NWALDWFDRI AEGNENTALH
VVEEDGHRTE VTFARMSERS AMAANWLREL GVRAGDRILL MLGNQAELWE IALAAMKLRA
VVIPATPLLG PVDLRDRIDR GRARHVIVRP EDIAKFDDVP GEYTRVVVGD SSRTEWIPYA
EVDGHGTEFE PDGPTRSDDP LMLYFTSGTT ARPKLVEHTH LTYPVGHLST MYWIGLRPGD
VHLNISSPGW AKHAWSNLFA PWNAEATVFI HNYTRFDAGR LMDEMDRAGV TSFCAPPTVW
RMLIQADLGR LAKPPRAVVA AGEPLNPEVI EHVRREWGVT IRDGFGQTET SVAVSNSPGQ
PLKVGSMGRP SPGFVIELLD PVTGRPGARE GEICLDLSAA PVGLMTGYHG DPERTSEAMA
GGFYRTGDIG ARDDDGYITY IGRSDDVFKA SDYKISPFEL ESALLEHPAV AEAAVVPSPD
PVRLAVPKAY VVLAEGWEPG ADTAKILFEH SRAVLAPYKR LRRLEFAPLP KTVSGKIRRI
ELREMTAAGS PAEYREEDHR
//
