ID A0A1V4AFW9_9ACTN Unreviewed; 564 AA.
AC A0A1V4AFW9;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 16.
DE SubName: Full=Acyl-CoA synthetase {ECO:0000313|EMBL:OON82437.1};
GN ORFNames=B1H18_04660 {ECO:0000313|EMBL:OON82437.1};
OS Streptomyces tsukubensis.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=83656 {ECO:0000313|EMBL:OON82437.1, ECO:0000313|Proteomes:UP000190539};
RN [1] {ECO:0000313|EMBL:OON82437.1, ECO:0000313|Proteomes:UP000190539}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=F601 {ECO:0000313|EMBL:OON82437.1,
RC ECO:0000313|Proteomes:UP000190539};
RA Zong G., Zhong C., Fu J., Qin R., Cao G.;
RT "Draft Genome Sequence of Streptomyces tsukubaensis F601, a Producer of the
RT immunosuppressant tacrolimus FK506.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OON82437.1}.
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DR EMBL; MVFC01000002; OON82437.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4AFW9; -.
DR STRING; 83656.B1H18_04660; -.
DR OrthoDB; 9803968at2; -.
DR Proteomes; UP000190539; Unassembled WGS sequence.
DR GO; GO:0016877; F:ligase activity, forming carbon-sulfur bonds; IEA:UniProt.
DR Gene3D; 3.30.300.30; -; 1.
DR Gene3D; 3.40.50.12780; N-terminal domain of ligase-like; 1.
DR InterPro; IPR025110; AMP-bd_C.
DR InterPro; IPR045851; AMP-bd_C_sf.
DR InterPro; IPR020845; AMP-binding_CS.
DR InterPro; IPR000873; AMP-dep_Synth/Lig_com.
DR InterPro; IPR042099; ANL_N_sf.
DR PANTHER; PTHR43767; LONG-CHAIN-FATTY-ACID--COA LIGASE; 1.
DR PANTHER; PTHR43767:SF1; NONRIBOSOMAL PEPTIDE SYNTHASE PES1 (EUROFUNG)-RELATED; 1.
DR Pfam; PF00501; AMP-binding; 1.
DR Pfam; PF13193; AMP-binding_C; 1.
DR SUPFAM; SSF56801; Acetyl-CoA synthetase-like; 1.
DR PROSITE; PS00455; AMP_BINDING; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000190539}.
FT DOMAIN 48..429
FT /note="AMP-dependent synthetase/ligase"
FT /evidence="ECO:0000259|Pfam:PF00501"
FT DOMAIN 479..554
FT /note="AMP-binding enzyme C-terminal"
FT /evidence="ECO:0000259|Pfam:PF13193"
SQ SEQUENCE 564 AA; 59961 MW; 4717569B2265196F CRC64;
MNDSPPGSAP ASSASPSAYA SRPWLGLLND IQRGPVDPPA SVVHVFGRAL ATAPERTALA
YFDGSLTYRE TDSLSDSVAG HLAARGIGRG DRVALMLQNT PHFVLALLGA WKAGAVVVPV
NPMYTAGEVG HVFADAGVSA LVCSDRAWEK YLRGAAAGTS VTTVLTTCER DLQTRDDSRV
LGFERLPRPE DTEDLLAVAR AGDRAPEGRT PGPDDIALIS YTSGTSGTPK GATNTHFNIA
YNAERQRTGA GIAEGACYYA LAPLFHITGM VCQLVACLAN AGTLALTYRF EAGTVLDAFA
EHRPAYTVGP STAFMALAAH PDATRDHFSS FQMISSGGAP LPPALVEKFR AGFGPYLHNG
YGLTECTAPC ASVPPGREAP VDPVSGTLAV GAPGPDTVVR IVDDHGQDVP IGEQGEIAVS
GPQVVPGYWR RPEATAEGFP GGELRTGDIG FMDRAGWLYV VDRKKDMINA SGFKVWPREV
EDVLYGHPAV REVAVVGVPD EYRGETVKAY VSLRGEEPVD AAELTAYCKE RLAAYKYPRQ
IEILPELPKT TSGKILRREL RSLK
//
