ID A0A1V4B0K9_9PAST Unreviewed; 726 AA.
AC A0A1V4B0K9;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE RecName: Full=DNA 3'-5' helicase {ECO:0000256|ARBA:ARBA00034808};
DE EC=5.6.2.4 {ECO:0000256|ARBA:ARBA00034808};
DE AltName: Full=DNA 3'-5' helicase II {ECO:0000256|ARBA:ARBA00034923};
GN Name=uvrD {ECO:0000313|EMBL:STO60881.1};
GN ORFNames=NCTC1659_02182 {ECO:0000313|EMBL:STO60881.1};
OS Canicola haemoglobinophilus.
OC Bacteria; Pseudomonadota; Gammaproteobacteria; Pasteurellales;
OC Pasteurellaceae; Canicola.
OX NCBI_TaxID=733 {ECO:0000313|EMBL:STO60881.1, ECO:0000313|Proteomes:UP000254329};
RN [1] {ECO:0000313|EMBL:STO60881.1, ECO:0000313|Proteomes:UP000254329}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=NCTC1659 {ECO:0000313|EMBL:STO60881.1,
RC ECO:0000313|Proteomes:UP000254329};
RG Pathogen Informatics;
RA Doyle S.;
RL Submitted (JUN-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=ATP + H2O = ADP + H(+) + phosphate; Xref=Rhea:RHEA:13065,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:30616,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:456216; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034618};
CC -!- CATALYTIC ACTIVITY:
CC Reaction=Couples ATP hydrolysis with the unwinding of duplex DNA by
CC translocating in the 3'-5' direction.; EC=5.6.2.4;
CC Evidence={ECO:0000256|ARBA:ARBA00034617};
CC -!- SIMILARITY: Belongs to the helicase family. UvrD subfamily.
CC {ECO:0000256|ARBA:ARBA00009922}.
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DR EMBL; UGHF01000001; STO60881.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4B0K9; -.
DR STRING; 733.B0186_06590; -.
DR Proteomes; UP000254329; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:RHEA.
DR GO; GO:0003677; F:DNA binding; IEA:InterPro.
DR GO; GO:0003678; F:DNA helicase activity; IEA:InterPro.
DR GO; GO:0006268; P:DNA unwinding involved in DNA replication; IEA:InterPro.
DR CDD; cd17932; DEXQc_UvrD; 1.
DR Gene3D; 1.10.10.160; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 2.
DR InterPro; IPR013986; DExx_box_DNA_helicase_dom_sf.
DR InterPro; IPR005753; DNA_helicase_ATP-dep_UvrD.
DR InterPro; IPR014017; DNA_helicase_UvrD-like_C.
DR InterPro; IPR000212; DNA_helicase_UvrD/REP.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR014016; UvrD-like_ATP-bd.
DR NCBIfam; TIGR01075; uvrD; 1.
DR PANTHER; PTHR11070:SF2; ATP-DEPENDENT DNA HELICASE SRS2; 1.
DR PANTHER; PTHR11070; UVRD / RECB / PCRA DNA HELICASE FAMILY MEMBER; 1.
DR Pfam; PF21196; PcrA_UvrD_tudor; 1.
DR Pfam; PF00580; UvrD-helicase; 1.
DR Pfam; PF13361; UvrD_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51198; UVRD_HELICASE_ATP_BIND; 1.
DR PROSITE; PS51217; UVRD_HELICASE_CTER; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Helicase {ECO:0000256|ARBA:ARBA00022806, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00560};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741, ECO:0000256|PROSITE-
KW ProRule:PRU00560}; Reference proteome {ECO:0000313|Proteomes:UP000254329}.
FT DOMAIN 8..290
FT /note="UvrD-like helicase ATP-binding"
FT /evidence="ECO:0000259|PROSITE:PS51198"
FT DOMAIN 291..568
FT /note="UvrD-like helicase C-terminal"
FT /evidence="ECO:0000259|PROSITE:PS51217"
FT BINDING 29..36
FT /ligand="ATP"
FT /ligand_id="ChEBI:CHEBI:30616"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00560"
SQ SEQUENCE 726 AA; 83354 MW; 213357B085C8C37B CRC64;
MDISELLDEL NDKQRNAVAA PLGNYLVLAG AGSGKTRVLT YRVAWLSAVE NVPESSIMAV
TFTNKAAAEM RHRIEATLAR YSNQRLFGMW IGTFHSIANR LLRAHYADAA LPQDFQILDS
EDQLRLVKRL MKLHQYDEKT FPYKQACWYI NNKKEEGLRP EQIEDNNDRQ EREWIKIYKI
YQDACDRAGL VDFPELLLRA YELWLKNPHI LHHYQHRFQH ILVDEFQDTN KIQYAWIKLL
AGTQSKVMIV GDDDQSIYGW RGAQVENIHR FLKDFAKAEI IRLEQNYRST GNILESANEL
ISNNSKRLGK DLWTSGNKGE PVGIYAAFNE LDEALFVSSQ VQSWLDNGGK FDDCAVLYRS
NSQSRVIEEA FLRAKIPYRI YGGMRFFERQ EIKDALAYLR LIANRQDDAA FERVVNTPPR
GIGDRTLDIL RNLTRERQIT LWQATQLAIQ GQLIPARSIT SLLRFIELIN SLQQETAEMP
LFAQTDFVIK HSGLYEMYKQ EKGDKGEVRI ENLEELVTAT REFVKPSEAE DMSDLVAFLT
HASLEAGEEQ AAPHQSCVQM MTLHSAKGLE FPRVFIVGME EGLFPSFRSG EDLERLEEER
RLAYVGITRA KQKLTLCYAE LRRLYGKDEK HIPSRFIAEL PKECIQEVRL RGKVTRAYNQ
SAVGSIAKNN VSDSAWKVGQ KVKHEKFGQG TVINVEGADN NTRLQIAFQG QGIKWLIAHL
AKLEKL
//
