ID A0A1V4D5E7_9ACTN Unreviewed; 745 AA.
AC A0A1V4D5E7;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 29.
DE SubName: Full=Bifunctional (P)ppGpp synthetase/guanosine-3',5'-bis(Diphosphate) 3'-pyrophosphohydrolase {ECO:0000313|EMBL:OPF79746.1};
GN ORFNames=VT50_0215170 {ECO:0000313|EMBL:OPF79746.1};
OS Streptomyces antioxidans.
OC Bacteria; Actinomycetota; Actinomycetes; Kitasatosporales;
OC Streptomycetaceae; Streptomyces.
OX NCBI_TaxID=1507734 {ECO:0000313|EMBL:OPF79746.1, ECO:0000313|Proteomes:UP000033615};
RN [1] {ECO:0000313|EMBL:OPF79746.1, ECO:0000313|Proteomes:UP000033615}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=MUSC164 {ECO:0000313|Proteomes:UP000033615};
RA Lee L.-H., Ser H.-L.;
RT "Genome sequence of Streptomyces antioxidans MUSC 164.";
RL Submitted (DEC-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- PATHWAY: Purine metabolism. {ECO:0000256|ARBA:ARBA00025704}.
CC -!- SIMILARITY: Belongs to the RelA/SpoT family.
CC {ECO:0000256|ARBA:ARBA00007476}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPF79746.1}.
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DR EMBL; LAKD02000035; OPF79746.1; -; Genomic_DNA.
DR RefSeq; WP_046087857.1; NZ_LAKD02000035.1.
DR AlphaFoldDB; A0A1V4D5E7; -.
DR OrthoDB; 9805041at2; -.
DR Proteomes; UP000033615; Unassembled WGS sequence.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0015969; P:guanosine tetraphosphate metabolic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00077; HDc; 1.
DR CDD; cd05399; NT_Rel-Spo_like; 1.
DR Gene3D; 3.10.20.30; -; 1.
DR Gene3D; 3.30.70.260; -; 1.
DR Gene3D; 3.30.460.10; Beta Polymerase, domain 2; 1.
DR Gene3D; 1.10.3210.10; Hypothetical protein af1432; 1.
DR InterPro; IPR045865; ACT-like_dom_sf.
DR InterPro; IPR002912; ACT_dom.
DR InterPro; IPR012675; Beta-grasp_dom_sf.
DR InterPro; IPR003607; HD/PDEase_dom.
DR InterPro; IPR006674; HD_domain.
DR InterPro; IPR043519; NT_sf.
DR InterPro; IPR007685; RelA_SpoT.
DR InterPro; IPR004095; TGS.
DR InterPro; IPR012676; TGS-like.
DR PANTHER; PTHR21262:SF31; BIFUNCTIONAL (P)PPGPP SYNTHASE_HYDROLASE SPOT; 1.
DR PANTHER; PTHR21262; GUANOSINE-3',5'-BIS DIPHOSPHATE 3'-PYROPHOSPHOHYDROLASE; 1.
DR Pfam; PF13291; ACT_4; 1.
DR Pfam; PF13328; HD_4; 1.
DR Pfam; PF04607; RelA_SpoT; 1.
DR Pfam; PF02824; TGS; 1.
DR SMART; SM00471; HDc; 1.
DR SMART; SM00954; RelA_SpoT; 1.
DR SUPFAM; SSF55021; ACT-like; 1.
DR SUPFAM; SSF109604; HD-domain/PDEase-like; 1.
DR SUPFAM; SSF81301; Nucleotidyltransferase; 1.
DR SUPFAM; SSF81271; TGS-like; 1.
DR PROSITE; PS51671; ACT; 1.
DR PROSITE; PS51831; HD; 1.
DR PROSITE; PS51880; TGS; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|ARBA:ARBA00022840};
KW Hydrolase {ECO:0000313|EMBL:OPF79746.1};
KW Kinase {ECO:0000256|ARBA:ARBA00022777};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022840};
KW Transferase {ECO:0000256|ARBA:ARBA00022777}.
FT DOMAIN 87..184
FT /note="HD"
FT /evidence="ECO:0000259|PROSITE:PS51831"
FT DOMAIN 429..490
FT /note="TGS"
FT /evidence="ECO:0000259|PROSITE:PS51880"
FT DOMAIN 665..739
FT /note="ACT"
FT /evidence="ECO:0000259|PROSITE:PS51671"
FT REGION 526..587
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 547..576
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 745 AA; 80352 MW; 96A930C3F315AFE2 CRC64;
MSAEATDQAP FGRRRGLPRI DLRNLRRFSR AALLGSASRG RLPDAIEHVA KVHRAHHPGA
DLDVLRNAYV LAESSHRGQM RKSGEPYITH PLAVTLILAE LGAETTTLTA SLLHDTVEDT
DVTLDQVGEQ FGEEVRFLVD GVTKLEKVDY GAAAEPETFR KMLVATGNDV RVMSIKLADR
LHNMRTLGVM RPEKQARIAR VTGDVLIPLA ERLGVQALKT ELEDLVFAIL HPAEYARTRE
LLQAHADRPD PLAQAAEDVR GVLQEAGITA EVLVRPRHFV SVHRAGIKRG ELTGTDLGRL
LVLVSDDADC YAVLGELHTC FTPVISEFKD FIAVPKFNLY QSLHTAVAGR DGEVTEVLIR
THQMHRVAEA GVIALGNPYA PTEGADAPEG ERADPTRPGW LSRLLDWQSA TPDPDIFWTS
LRDDLAQDRE ITVFRSDGGT LGLSAGASCV DAAYALYGDD AHSCIGARVN GRIATLSTVL
RDGDTLQLLM ASDTRDTASH GPSPEWLDHA RTPAARIAIN RWLAAHPASQ HEPREAAEEP
ESASELTVQD AHDTQDAQNA QDAQVTPGSE APQGGQTVAA ASPGAGRPEA GIVVDLPGAT
VRLARCCTPV PPDAITGFAV RGGAVTVHRE RCAGAARMTS AGRTAVGVRW VDEDDGEGGG
DYRVTLFAEA FSRPHLLADL TEAIAAEGAE VVAAAVEPPR EQRVRHTYTL QLPDAGRLPT
LMRAMRNVPG VYDVTREGRR MAAAR
//
