ID A0A1V4I0P1_NITVU Unreviewed; 457 AA.
AC A0A1V4I0P1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 43.
DE RecName: Full=C4-dicarboxylate transport protein {ECO:0000256|HAMAP-Rule:MF_01300};
GN Name=dctA {ECO:0000256|HAMAP-Rule:MF_01300};
GN ORFNames=B2M20_05275 {ECO:0000313|EMBL:OPH83818.1};
OS Nitrobacter vulgaris.
OC Bacteria; Pseudomonadota; Alphaproteobacteria; Hyphomicrobiales;
OC Nitrobacteraceae; Nitrobacter.
OX NCBI_TaxID=29421 {ECO:0000313|EMBL:OPH83818.1, ECO:0000313|Proteomes:UP000189940};
RN [1] {ECO:0000313|EMBL:OPH83818.1, ECO:0000313|Proteomes:UP000189940}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Ab1 {ECO:0000313|EMBL:OPH83818.1,
RC ECO:0000313|Proteomes:UP000189940};
RA Mellbye B.L., Davis E.W., Spieck E., Chang J.H., Bottomley P.J.,
RA Sayavedra-Soto L.A.;
RT "Genome sequence of the nitrite-oxidizing bacterium Nitrobacter vulgaris
RT strain Ab1.";
RL Submitted (FEB-2017) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Responsible for the transport of dicarboxylates such as
CC succinate, fumarate, and malate across the membrane.
CC {ECO:0000256|HAMAP-Rule:MF_01300}.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|HAMAP-Rule:MF_01300};
CC Multi-pass membrane protein {ECO:0000256|HAMAP-Rule:MF_01300}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the dicarboxylate/amino acid:cation symporter
CC (DAACS) (TC 2.A.23) family. {ECO:0000256|ARBA:ARBA00006148,
CC ECO:0000256|HAMAP-Rule:MF_01300}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPH83818.1}.
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DR EMBL; MWPQ01000023; OPH83818.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4I0P1; -.
DR STRING; 29421.B2M20_05275; -.
DR OrthoDB; 9766690at2; -.
DR Proteomes; UP000189940; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015293; F:symporter activity; IEA:UniProtKB-UniRule.
DR GO; GO:0006835; P:dicarboxylic acid transport; IEA:UniProtKB-UniRule.
DR Gene3D; 1.10.3860.10; Sodium:dicarboxylate symporter; 1.
DR HAMAP; MF_01300; C4_dicarb_transport; 1.
DR InterPro; IPR023954; C4_dicarb_transport.
DR InterPro; IPR001991; Na-dicarboxylate_symporter.
DR InterPro; IPR018107; Na-dicarboxylate_symporter_CS.
DR InterPro; IPR036458; Na:dicarbo_symporter_sf.
DR PANTHER; PTHR42865:SF1; AEROBIC C4-DICARBOXYLATE TRANSPORT PROTEIN; 1.
DR PANTHER; PTHR42865; PROTON/GLUTAMATE-ASPARTATE SYMPORTER; 1.
DR Pfam; PF00375; SDF; 1.
DR PRINTS; PR00173; EDTRNSPORT.
DR SUPFAM; SSF118215; Proton glutamate symport protein; 1.
DR PROSITE; PS00713; NA_DICARBOXYL_SYMP_1; 1.
DR PROSITE; PS00714; NA_DICARBOXYL_SYMP_2; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|HAMAP-Rule:MF_01300};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|HAMAP-Rule:MF_01300};
KW Symport {ECO:0000256|ARBA:ARBA00022847, ECO:0000256|HAMAP-Rule:MF_01300};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|HAMAP-
KW Rule:MF_01300};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989, ECO:0000256|HAMAP-
KW Rule:MF_01300};
KW Transport {ECO:0000256|ARBA:ARBA00022448, ECO:0000256|HAMAP-Rule:MF_01300}.
FT TRANSMEM 20..38
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 58..76
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 88..110
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 161..178
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 185..203
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 209..230
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 237..261
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 309..328
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 335..355
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT TRANSMEM 361..384
FT /note="Helical"
FT /evidence="ECO:0000256|HAMAP-Rule:MF_01300"
FT REGION 427..457
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 457 AA; 48815 MW; FE4B0ED909DA6E46 CRC64;
METARSTTAG SPLKPFYKHL YAQVLTAIVL GVLLGHFYPH LGEAMKPLGD GFIKLIKMLI
APIIFCTVVH GIAGMDDMKK VGRVGIKALV YFEVVTSLAL IVGLIVVNIL QPGVGMNVDT
HALDTKSIQV YTTKAGQQGT VEFLMHIIPN TVVGAFAEGE ILQVLLFAIL FAFGLFMMGE
RGRPVLAFID IVSHTFFGIV GIIMKAAPIG AFGAMAFTIG KYGLGALLLL AKLMASFYLT
CVIFVIFVLG GIAWLVGFNI FKFINYIKEE LLIVLGTSSS ESVLPRMIEK MGNLGCKQSV
VGLVIPTGYS FNLDGTCIYL TMTAIFLAQA TNTELTLWQQ LGIIGVLLLT SKGAAGVTGS
GFIVLAATLA SVGTIPVASI ALILGVDRFM SEARALTNLV GNGVATVVIA KWENALDEER
MHRLLDQKPE LEASEPEVAM GPPDPLLPQA STTRTTS
//
