ID A0A1V4IG62_PATFA Unreviewed; 2091 AA.
AC A0A1V4IG62;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 08-NOV-2023, entry version 19.
DE SubName: Full=Ral GTPase-activating protein subunit alpha-2 isoform A {ECO:0000313|EMBL:OPJ58982.1};
GN Name=RALGAPA2 {ECO:0000313|EMBL:OPJ58982.1};
GN ORFNames=AV530_000704 {ECO:0000313|EMBL:OPJ58982.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ58982.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ58982.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ58982.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ58982.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ58982.1}.
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DR EMBL; LSYS01009753; OPJ58982.1; -; Genomic_DNA.
DR STRING; 372326.A0A1V4IG62; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.30.160.60; Classic Zinc Finger; 2.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR046859; RGPA/RALGAPB_N.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR InterPro; IPR036236; Znf_C2H2_sf.
DR InterPro; IPR013087; Znf_C2H2_type.
DR PANTHER; PTHR10063:SF2; RAL GTPASE-ACTIVATING PROTEIN SUBUNIT ALPHA-2; 1.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR Pfam; PF20412; RALGAPB_N; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR Pfam; PF00096; zf-C2H2; 4.
DR SMART; SM00355; ZnF_C2H2; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF57667; beta-beta-alpha zinc fingers; 2.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
DR PROSITE; PS00028; ZINC_FINGER_C2H2_1; 4.
DR PROSITE; PS50157; ZINC_FINGER_C2H2_2; 4.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00042};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00042}.
FT DOMAIN 1634..1842
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT DOMAIN 1910..1937
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 1982..2009
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 2022..2050
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT DOMAIN 2050..2078
FT /note="C2H2-type"
FT /evidence="ECO:0000259|PROSITE:PS50157"
FT REGION 739..853
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1528..1553
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1930..1977
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 759..801
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 802..817
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2091 AA; 232821 MW; 255AEEB305739F8E CRC64;
MFSRKGHADV RKSTQKALDP KRDVLTRLKH LRALLDIVDG SDLKQFFESN YSQIYFIFYE
NFITLENSLK QKGNKSQREE LDSILFLFEK ILQLLPERIF YRWHFRSIGS ILKKLLHTGN
CLKIRCEGMR LXXXXPKIFP EEITPLVPAV SGEKIAEDQT CYFLQLLLKY MVIQAASLEW
KNKENQDTGF KFLFALFRKY YLPHLFPSFT KLTNLYKPVL DIPDTRPRPV YITATRNNEN
VYSTKIPFMA ARVVFIKWLV TFFLEKKYLT AVQNTKNGGE MLPKIIQTVG GVNQDRGAEL
EPGVPPVGEL DRSHSNCSTL SDRRLSSSSL CSIEEQHRGV YDMVQRILLS TRGYVNFVNE
VFRQAFLLPP CDISATRKVV KVYRKWILQE KPVFMEEPDR KEDAQDAAVS VEDSSVQTDG
KHLSSDGGRH KRSSSWGRTY SFTSAVTRGC VVEDEDRNVR AGAQAALQVF LTNSANVFLL
EPCVEVPVLL KEQVDACKAV LSIFRRMIME LSMDKKTWEQ MLQILLRITE AVMQKPKENQ
MKDTFAQSLS GLLFRTLIVA WVRANLSVYI SRELWDQLLG VLSALTGWEE LITEWANIMD
SLTAVLARTV YGLDMTSLPL DKLSEQKEKK QRGKGGILEP QKTAVVGRSF SLSWKSHPEV
VEPMRFRSAT TSGAPGVEKA RNIVRQRATA KRSQSISNCV HLCEALPATK SVPLLLHTVS
SLLPGISYTS CSHRLSEVEE SQQLENSSGP EAAGLFAEQE QQLTRSSSAS DLTDQFPSDF
FQGKKAGSSH NLTSSDCKSV QENKGCTKKE HEAEQVPVRR SSSTAELDLK AALQQSHGDC
REREKSASVS SDTSIGDAEV EMALLPWPAA QDEQDGRLAA CADPDAPRWL QLSPSDTANL
TDSSEFLADD CSIIAGGSLV GWHPDSAAVL WRRVLGILGD VNNIASPKIH AKVFSYLYDL
WYKLAKIRDN LAISVDNQST PSPPALIPPL RIFASWLFKA TTLPNEYKEG KLQAYRLICA
MMTRRQDLLP NSDFLVHFYF VMHLGLTSED QDILNTVIKH CPPCFFFLGL PGFTLLIGDF
ITAAARVLSS DAPEAPRSEA HTILGSLVCF PNIYQEIPLL RPISESGDII AGTADVKCYL
INILLKNATE EPSEAARCVA ICGLGVWICE ELAQGSNHPQ VKEAINVIGV TLKFSNKLVA
QVACDVLQLL VSYWQKLQKY ESSLSRKITE ILVATIAFLL PSAEYSSVEA DKKFIVSLLL
CLLDWCMALP MKVLLEPVSA GAPEEQHAAK APLLDHIYRV LHCCVNGSST HTQQSHYVLS
LADLSCSDYD PFLPLGNVRS SEPAQSPCAA DLGNLLTVAE EKRRRNLELI PLTARMVMTH
LVNHLSHFPL SGGPAVLHSL LSENHDNSFV DSSELSSDVF RSPNLQLFVF NDSTLISYLQ
IPAEKPPGPE PAAAPSDVRV IVRDISGKYS WDGRVLYGPL EGCLPPHRAP SAFAISAQPE
CRLLSQKDVS QAEEGEDALD QLLERIGSSS PECLPHPQRK LNEPSPPPFG MSRDQENAIT
EALMRQSAQE TEYMLKHGSD LSMGVARQEP PRPAEPQASF YFCRLLLNDL GMNSWDRRKS
FHLLKKNAKL LRELKNLDSR QCRETHKIAV FYIAEGQEDK CSILSNARGS QAYEDFVAGL
GWEVDLSTHS GFMGGLQRNG STGQTAPYYA TSTVEIIFHV STRMPSDSDD SLTKKLRHLG
NDEVHIVWSE HTRNYRRGII PTDFGDVLIV IYPMKNHMFF IEIMKKPEVP FFGPLFNGAI
VTATLLSSLI CATCINASRA VKSLIPLYQS LYPFGPRGPA SSVLLGEDEV TTSPVLGLRI
KEGPVEAPAK ARGGCARPLG EFICQLCKEE YGDPFALAQH RCSRIVRVEY RCPECDKVFS
CPANLASHRR WHKPRPPAAK GGPEAGRAPA EEPPKEAGGS GSERDTPSPG GASEAGSEEG
LFECPRCAKR FRRQAYLRKH LLSHPAPEPA AEEPPAPPAE CRLCPVCGET FPSKSSQERH
LRLLHAAQVF PCKYCPATFY SSPGLTRHIN KCHPSENRQV ILLQVPLRPA C
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