ID A0A1V4IP34_9CLOT Unreviewed; 429 AA.
AC A0A1V4IP34;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 22.
DE SubName: Full=Methionine gamma-lyase {ECO:0000313|EMBL:OPJ61570.1};
DE EC=4.4.1.11 {ECO:0000313|EMBL:OPJ61570.1};
DE SubName: Full=O-acetylhomoserine aminocarboxypropyltransferase/cysteine synthase {ECO:0000313|EMBL:RII34023.1};
GN Name=mdeA_4 {ECO:0000313|EMBL:OPJ61570.1};
GN ORFNames=CLCHR_23640 {ECO:0000313|EMBL:OPJ61570.1}, D2A34_12620
GN {ECO:0000313|EMBL:RII34023.1};
OS Clostridium chromiireducens.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=225345 {ECO:0000313|EMBL:OPJ61570.1, ECO:0000313|Proteomes:UP000191056};
RN [1] {ECO:0000313|EMBL:OPJ61570.1, ECO:0000313|Proteomes:UP000191056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23318 {ECO:0000313|EMBL:OPJ61570.1,
RC ECO:0000313|Proteomes:UP000191056};
RA Poehlein A., Daniel R.;
RT "Genome sequence of Clostridium chromiireducens DSM 23318.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:RII34023.1, ECO:0000313|Proteomes:UP000265930}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C1 {ECO:0000313|EMBL:RII34023.1,
RC ECO:0000313|Proteomes:UP000265930};
RA Xing M., Wei Y., Ang E.L., Zhao H., Zhang Y.;
RT "Genome of Clostridium chromiireducens C1, DSM12136.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|RuleBase:RU362118};
CC -!- SIMILARITY: Belongs to the trans-sulfuration enzymes family.
CC {ECO:0000256|ARBA:ARBA00009077, ECO:0000256|RuleBase:RU362118}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ61570.1}.
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DR EMBL; MZGT01000029; OPJ61570.1; -; Genomic_DNA.
DR EMBL; QXDJ01000003; RII34023.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4IP34; -.
DR STRING; 225345.CLCHR_23640; -.
DR OrthoDB; 9780685at2; -.
DR Proteomes; UP000191056; Unassembled WGS sequence.
DR Proteomes; UP000265930; Unassembled WGS sequence.
DR GO; GO:0018826; F:methionine gamma-lyase activity; IEA:UniProtKB-EC.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0016765; F:transferase activity, transferring alkyl or aryl (other than methyl) groups; IEA:InterPro.
DR GO; GO:0019346; P:transsulfuration; IEA:InterPro.
DR CDD; cd00614; CGS_like; 1.
DR Gene3D; 3.90.1150.10; Aspartate Aminotransferase, domain 1; 1.
DR Gene3D; 3.40.640.10; Type I PLP-dependent aspartate aminotransferase-like (Major domain); 1.
DR InterPro; IPR000277; Cys/Met-Metab_PyrdxlP-dep_enz.
DR InterPro; IPR006235; OAc-hSer/O-AcSer_sulfhydrylase.
DR InterPro; IPR015424; PyrdxlP-dep_Trfase.
DR InterPro; IPR015421; PyrdxlP-dep_Trfase_major.
DR InterPro; IPR015422; PyrdxlP-dep_Trfase_small.
DR NCBIfam; TIGR01326; OAH_OAS_sulfhy; 1.
DR PANTHER; PTHR43797; HOMOCYSTEINE/CYSTEINE SYNTHASE; 1.
DR PANTHER; PTHR43797:SF2; HOMOCYSTEINE_CYSTEINE SYNTHASE; 1.
DR Pfam; PF01053; Cys_Met_Meta_PP; 1.
DR PIRSF; PIRSF001434; CGS; 1.
DR SUPFAM; SSF53383; PLP-dependent transferases; 1.
DR PROSITE; PS00868; CYS_MET_METAB_PP; 1.
PE 3: Inferred from homology;
KW Lyase {ECO:0000313|EMBL:OPJ61570.1};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR001434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000191056};
KW Transferase {ECO:0000313|EMBL:RII34023.1}.
FT MOD_RES 212
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR001434-2"
SQ SEQUENCE 429 AA; 46488 MW; 32279276A2590AE1 CRC64;
MSNQERKLKF ETLQLHVGQE QADPTTDSRA VPIYQTTSYV FRNSAHAAAR FGLADAGNIY
GRLTNSTQDV FERRVAALEG GVAGLAVASG AASIAYSIQN ITKAGDHVVA AKTIYGGTYN
LLAHTLADYG VTTTFVDPGN LENFKNAIKD NTKAIFIESL GNPNSNIIDV DALSEIAHNH
KIPLIVDNTF GTPYLFRPIE HGADIVVHSA TKFIGGHGTS LGGVIVDSGK FDWIGSGKFP
QLTEADPSYH GIKFAEVVGP AAYVTRIRAI LLRDTGASIS PFNAFLLLQG LETLSLRLER
HVENTLKVVD FLNKHPKVEK VNHPSLADSP DNALYNKYFP NGAGSIFTFE IKGKAKEAQE
FIDKLEIFSL LANVADVKSL VIHPASTTHS QLSGEELLDQ GIKPNTVRLS IGTEHIDDII
YDLSQAFES
//
