ID   A0A1V4IWU3_9CLOT        Unreviewed;       357 AA.
AC   A0A1V4IWU3;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   27-MAR-2024, entry version 18.
DE   SubName: Full=dTDP-glucose 4,6-dehydratase {ECO:0000313|EMBL:OPJ64518.1};
DE            EC=4.2.1.46 {ECO:0000313|EMBL:OPJ64518.1};
GN   Name=rfbB_1 {ECO:0000313|EMBL:OPJ64518.1};
GN   ORFNames=CLCHR_11650 {ECO:0000313|EMBL:OPJ64518.1};
OS   Clostridium chromiireducens.
OC   Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC   Clostridium.
OX   NCBI_TaxID=225345 {ECO:0000313|EMBL:OPJ64518.1, ECO:0000313|Proteomes:UP000191056};
RN   [1] {ECO:0000313|EMBL:OPJ64518.1, ECO:0000313|Proteomes:UP000191056}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=DSM 23318 {ECO:0000313|EMBL:OPJ64518.1,
RC   ECO:0000313|Proteomes:UP000191056};
RA   Poehlein A., Daniel R.;
RT   "Genome sequence of Clostridium chromiireducens DSM 23318.";
RL   Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
CC   -!- COFACTOR:
CC       Name=NAD(+); Xref=ChEBI:CHEBI:57540;
CC         Evidence={ECO:0000256|ARBA:ARBA00001911};
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OPJ64518.1}.
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DR   EMBL; MZGT01000012; OPJ64518.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V4IWU3; -.
DR   STRING; 225345.CLCHR_11650; -.
DR   OrthoDB; 9811743at2; -.
DR   Proteomes; UP000191056; Unassembled WGS sequence.
DR   GO; GO:0008460; F:dTDP-glucose 4,6-dehydratase activity; IEA:UniProtKB-EC.
DR   GO; GO:0070403; F:NAD+ binding; IEA:InterPro.
DR   GO; GO:0048040; F:UDP-glucuronate decarboxylase activity; IEA:InterPro.
DR   GO; GO:0042732; P:D-xylose metabolic process; IEA:InterPro.
DR   Gene3D; 3.40.50.720; NAD(P)-binding Rossmann-like Domain; 1.
DR   InterPro; IPR001509; Epimerase_deHydtase.
DR   InterPro; IPR036291; NAD(P)-bd_dom_sf.
DR   InterPro; IPR044516; UXS.
DR   PANTHER; PTHR43078:SF6; UDP-GLUCURONIC ACID DECARBOXYLASE 1; 1.
DR   PANTHER; PTHR43078; UDP-GLUCURONIC ACID DECARBOXYLASE-RELATED; 1.
DR   Pfam; PF01370; Epimerase; 1.
DR   SUPFAM; SSF51735; NAD(P)-binding Rossmann-fold domains; 1.
PE   4: Predicted;
KW   Lyase {ECO:0000313|EMBL:OPJ64518.1};
KW   Reference proteome {ECO:0000313|Proteomes:UP000191056}.
FT   DOMAIN          30..273
FT                   /note="NAD-dependent epimerase/dehydratase"
FT                   /evidence="ECO:0000259|Pfam:PF01370"
SQ   SEQUENCE   357 AA;  40542 MW;  D18106A76E3E7F0E CRC64;
     MNLVNDEMNK IKKYVNEIDN LFDDLRGSTI LITGSTGLIG SQLVKFLAAV NRINNLKIKI
     IALARNASKV SKVFGDLAKY PELEIIYGDI LNDIQYEKQI DYIIHSASIT ASKDFVEYPV
     ETIHTALSGT ENMLKLAKDK KVKSIIYISS LEIYGITKEI DIKENEYGYI EHLNVRSSYS
     EGKRMAECLC CSYYKEYKVP VKIIRLTQSF GSGVMYDDNR VFAQFARGII ENKNIVLYTR
     GETMRSYLHT IDAAYAIITV LLKGKNGEAY NAANQDTMIS IANMAQRLVE NYPQSKSQVV
     FEVDKNIEKR GFNPVVKINL NTEKINELGW TPKFSLEDMY EDMIESMKIS QKGEGIV
//