ID A0A1V4IZT9_9CLOT Unreviewed; 142 AA.
AC A0A1V4IZT9;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=3-hydroxyacyl-[acyl-carrier-protein] dehydratase {ECO:0000256|ARBA:ARBA00013167};
DE EC=4.2.1.59 {ECO:0000256|ARBA:ARBA00013167};
GN Name=fabZ {ECO:0000313|EMBL:OPJ65350.1};
GN ORFNames=CLCHR_09260 {ECO:0000313|EMBL:OPJ65350.1}, D2A34_07255
GN {ECO:0000313|EMBL:RII34998.1}, GKZ28_10735
GN {ECO:0000313|EMBL:MVX64165.1};
OS Clostridium chromiireducens.
OC Bacteria; Bacillota; Clostridia; Eubacteriales; Clostridiaceae;
OC Clostridium.
OX NCBI_TaxID=225345 {ECO:0000313|EMBL:OPJ65350.1, ECO:0000313|Proteomes:UP000191056};
RN [1] {ECO:0000313|EMBL:OPJ65350.1, ECO:0000313|Proteomes:UP000191056}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=DSM 23318 {ECO:0000313|EMBL:OPJ65350.1,
RC ECO:0000313|Proteomes:UP000191056};
RA Poehlein A., Daniel R.;
RT "Genome sequence of Clostridium chromiireducens DSM 23318.";
RL Submitted (MAR-2017) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:RII34998.1, ECO:0000313|Proteomes:UP000265930}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=C1 {ECO:0000313|EMBL:RII34998.1,
RC ECO:0000313|Proteomes:UP000265930};
RA Xing M., Wei Y., Ang E.L., Zhao H., Zhang Y.;
RT "Genome of Clostridium chromiireducens C1, DSM12136.";
RL Submitted (AUG-2018) to the EMBL/GenBank/DDBJ databases.
RN [3] {ECO:0000313|EMBL:MVX64165.1}
RP NUCLEOTIDE SEQUENCE.
RC STRAIN=NM79_F5 {ECO:0000313|EMBL:MVX64165.1};
RA Navarre W., Wong E.;
RT "Microbes associate with the intestines of laboratory mice.";
RL Submitted (DEC-2019) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in unsaturated fatty acids biosynthesis. Catalyzes
CC the dehydration of short chain beta-hydroxyacyl-ACPs and long chain
CC saturated and unsaturated beta-hydroxyacyl-ACPs.
CC {ECO:0000256|ARBA:ARBA00025049}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC -!- SIMILARITY: Belongs to the thioester dehydratase family. FabZ
CC subfamily. {ECO:0000256|ARBA:ARBA00009174}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ65350.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; WSRQ01000014; MVX64165.1; -; Genomic_DNA.
DR EMBL; MZGT01000009; OPJ65350.1; -; Genomic_DNA.
DR EMBL; QXDJ01000002; RII34998.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4IZT9; -.
DR STRING; 225345.CLCHR_09260; -.
DR OrthoDB; 9772788at2; -.
DR Proteomes; UP000191056; Unassembled WGS sequence.
DR Proteomes; UP000265930; Unassembled WGS sequence.
DR Proteomes; UP000656077; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0019171; F:(3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0008659; F:(3R)-hydroxymyristoyl-[acyl-carrier-protein] dehydratase activity; IEA:UniProtKB-EC.
DR GO; GO:0006633; P:fatty acid biosynthetic process; IEA:InterPro.
DR GO; GO:0009245; P:lipid A biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd01288; FabZ; 1.
DR Gene3D; 3.10.129.10; Hotdog Thioesterase; 1.
DR InterPro; IPR013114; FabA_FabZ.
DR InterPro; IPR010084; FabZ.
DR InterPro; IPR029069; HotDog_dom_sf.
DR NCBIfam; TIGR01750; fabZ; 1.
DR PANTHER; PTHR30272; 3-HYDROXYACYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE; 1.
DR PANTHER; PTHR30272:SF1; 3-HYDROXYACYL-[ACYL-CARRIER-PROTEIN] DEHYDRATASE FABZ; 1.
DR Pfam; PF07977; FabA; 1.
DR SUPFAM; SSF54637; Thioesterase/thiol ester dehydrase-isomerase; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Lipid A biosynthesis {ECO:0000256|ARBA:ARBA00022556};
KW Lipid biosynthesis {ECO:0000256|ARBA:ARBA00022516};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Lyase {ECO:0000256|ARBA:ARBA00023239, ECO:0000313|EMBL:OPJ65350.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000191056}.
SQ SEQUENCE 142 AA; 15749 MW; 618C8D8715EF49A0 CRC64;
MLNVNEIKEI IPHRYPMLLI DRVIEMDIEE KLFVKGYKNV SANEAYFQGH YPQEPIMPGV
LQIEALAQAG AVAILSMEKY KGKTPLFAGT NKVRFKGKVV PGDRLDLYCE IIKIKGPIGI
GKGIASVDGK TVCEAEILFA LQ
//
