ID A0A1V4J6K1_PATFA Unreviewed; 675 AA.
AC A0A1V4J6K1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 15.
DE SubName: Full=SH2 domain-containing protein 3C isoform C {ECO:0000313|EMBL:OPJ67851.1};
GN Name=SH2D3C {ECO:0000313|EMBL:OPJ67851.1};
GN ORFNames=AV530_002060 {ECO:0000313|EMBL:OPJ67851.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ67851.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ67851.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ67851.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ67851.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ67851.1}.
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DR EMBL; LSYS01008925; OPJ67851.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4J6K1; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0001784; F:phosphotyrosine residue binding; IEA:InterPro.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd10337; SH2_BCAR3; 1.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR044102; SH2_SHEP1/BCAR3/NSP1.
DR PANTHER; PTHR14247; BREAST CANCER ANTI-ESTROGEN RESISTANCE PROTEIN 3 HOMOLOG-LIKE PROTEIN; 1.
DR PANTHER; PTHR14247:SF6; SH2 DOMAIN-CONTAINING PROTEIN 3C; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00017; SH2; 1.
DR PRINTS; PR00401; SH2DOMAIN.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00252; SH2; 1.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50001; SH2; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW SH2 domain {ECO:0000256|ARBA:ARBA00022999, ECO:0000256|PROSITE-
KW ProRule:PRU00191}.
FT DOMAIN 65..164
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 401..669
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
FT REGION 1..21
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 675 AA; 75230 MW; E5C6435A7534A221 CRC64;
MTAVGRRFPT LGQGSHHDGL ESGSEYVKVQ FSKEKYILDS SPEKLHKELE EELKLSSTDL
RSHAWYHGRI PREVSESLVQ RNGDFLIRDS LTSVGDYVLT CRWRNEPLHF KINKATVKSS
EGHTRVQYLF EQESFDNVPA LVRFYVGNRK AISEQSGAIV YCPINRTFPL RYLEASYGLA
NGKHGGPHSP TTQKGGHIKR RSITMTDGLT ADKITRAEGC PTSVSLPHHR DIIRNCAVSV
DQIQDLHSPM SPISENPASP AYSTVTRLKP HACQAGIAPA SPVIRSYSDP DTGHYCQLHP
TSPIGRDRPA HDTKVLPTKS YVERLKVEEG QRGTVENSSG EAEAGQRLKG ELDFMGFVPP
TMETTSSFNP AAFQSLLIPL ENKPLEMAVL KKVKELLAEV DVKTLAKHIT KVDCLVARIL
GVTAEIQRLM GVSSGMELLT LPHGHQLRLD LLERFHTMSI MIAVDILGCT GSTEERAALL
HKTIQLAAEL KSTMGNMFSF AAVMNALEMT QITRLEQTWM VLRQRHTEGA ILYEKKLKPF
LKNLNEGKEG PPLTNTTFPH IIPLVTLLER DEALTDSPEP WETTDSGVEV VMAHLEAARM
VAHHGGLYHT NAEVKLQGFQ GRAELLEVFS TEFQLRLLWG SRGAESSQAE RYEKFDKVLT
ALSHKLEPAV RFSEL
//
