ID A0A1V4JE21_PATFA Unreviewed; 1291 AA.
AC A0A1V4JE21;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 27.
DE RecName: Full=DNA polymerase subunit gamma-1 {ECO:0000256|ARBA:ARBA00015350};
DE EC=2.7.7.7 {ECO:0000256|ARBA:ARBA00012417};
DE AltName: Full=Mitochondrial DNA polymerase catalytic subunit {ECO:0000256|ARBA:ARBA00031966};
GN Name=POLG {ECO:0000313|EMBL:OPJ70458.1};
GN ORFNames=AV530_019594 {ECO:0000313|EMBL:OPJ70458.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ70458.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ70458.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ70458.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ70458.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Involved in the replication of mitochondrial DNA. Associates
CC with mitochondrial DNA. {ECO:0000256|ARBA:ARBA00025629}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=a 2'-deoxyribonucleoside 5'-triphosphate + DNA(n) =
CC diphosphate + DNA(n+1); Xref=Rhea:RHEA:22508, Rhea:RHEA-COMP:17339,
CC Rhea:RHEA-COMP:17340, ChEBI:CHEBI:33019, ChEBI:CHEBI:61560,
CC ChEBI:CHEBI:173112; EC=2.7.7.7;
CC Evidence={ECO:0000256|ARBA:ARBA00024632};
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|ARBA:ARBA00001946};
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|ARBA:ARBA00004173}.
CC -!- SIMILARITY: Belongs to the DNA polymerase type-A family.
CC {ECO:0000256|ARBA:ARBA00007705}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ70458.1}.
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DR EMBL; LSYS01007908; OPJ70458.1; -; Genomic_DNA.
DR STRING; 372326.A0A1V4JE21; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0005760; C:gamma DNA polymerase complex; IEA:InterPro.
DR GO; GO:0042645; C:mitochondrial nucleoid; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003887; F:DNA-directed DNA polymerase activity; IEA:UniProtKB-EC.
DR GO; GO:0006264; P:mitochondrial DNA replication; IEA:InterPro.
DR CDD; cd08641; DNA_pol_gammaA; 1.
DR Gene3D; 3.30.420.390; -; 2.
DR Gene3D; 3.30.70.370; -; 1.
DR Gene3D; 1.10.150.20; 5' to 3' exonuclease, C-terminal subdomain; 1.
DR InterPro; IPR019760; DNA-dir_DNA_pol_A_CS.
DR InterPro; IPR002297; DNA-dir_DNA_pol_A_mt.
DR InterPro; IPR001098; DNA-dir_DNA_pol_A_palm_dom.
DR InterPro; IPR043502; DNA/RNA_pol_sf.
DR InterPro; IPR041336; DNApol_Exo.
DR InterPro; IPR047580; POLG_palm_dom.
DR InterPro; IPR012337; RNaseH-like_sf.
DR PANTHER; PTHR10267; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR PANTHER; PTHR10267:SF0; DNA POLYMERASE SUBUNIT GAMMA-1; 1.
DR Pfam; PF18136; DNApol_Exo; 1.
DR PRINTS; PR00867; DNAPOLG.
DR SMART; SM00482; POLAc; 1.
DR SUPFAM; SSF56672; DNA/RNA polymerases; 1.
DR SUPFAM; SSF53098; Ribonuclease H-like; 1.
DR PROSITE; PS00447; DNA_POLYMERASE_A; 1.
PE 3: Inferred from homology;
KW DNA replication {ECO:0000256|ARBA:ARBA00022705};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Mitochondrion {ECO:0000256|ARBA:ARBA00023128};
KW Mitochondrion nucleoid {ECO:0000256|ARBA:ARBA00023271};
KW Nucleotidyltransferase {ECO:0000256|ARBA:ARBA00022695};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 927..1202
FT /note="DNA-directed DNA polymerase family A palm"
FT /evidence="ECO:0000259|SMART:SM00482"
FT REGION 1..30
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 101..127
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 555..602
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..127
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 555..569
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1291 AA; 145481 MW; 7F6B9EA854BB2E59 CRC64;
MGSERYPHPD GPGPGGTGPV RPVAVGPQRH LASRPRGHLH CYVPAPCTEF PAGGLYHVGG
GLWRRTTRDG TSARPEAPPG ASVWIRPPAW ARRRGLLRPP GGSRECCSSS ASFPLPENLS
QEPAQGQRRM NPLNIQMLSR TLHEQIFRGA QVHYSAADIQ RSVEHLQRHD LWGKETSTLP
DVDLQLPRMY GDNIDEHFRI LAQKQSLPYL EAANELLQCE LPPMPAQWAW QLGWTRYGPD
GRAEAVDFPE ERAVVLDVEV CVADGHCPTL AVAVSPHAWY SWCSKRLLEQ RYSWSSHLTL
ADLIPLESPA GASCAGKQDW PERVVVGHNV AFDRAFIKEQ YLIQGSQVRF LDTMSMHMAI
SGLTGFQRSL WMAARHGKRK GLQQVKEHMK KTRSKAEGPA ITSWDWVHVS SINNLADVHA
LYVGGEPLQK EARELFVKGT MADIRSHFQD LMSYCARDVQ ATHEVFQEQL PLFMERCPHP
VTFAGMLEMG VSYLPVNGNW KRYLDDAQSI YEELQKEMKK SLMNLANDAC QLLHEDRYKD
DPWLWDLEWD TQEFKQKKNP GKKKKDQNGN SKAPVAAAGA DGTTQEWQED PGPPGEDEEL
EAPASRVHLE RLKETVVLQP KRLQHLPGHP GWYRKLCPRL EDAGWVPGPS LISLQMRVTP
KLMRLAWDGF PLHYSEKHGW GYLVPGRQDN LPAAPLEEKG PVCPHRVIEY LYRQHCLEKG
KEQLPGPEAA VEDEMLVMDG STMWQKVEEL SRLEVDVEEK MGRANQSLVQ EDADELCELA
EVSSRPSHHH GNGPYNDVNI PGCWFFKLPH KDGNDNNVGS PFAKDFLPQM EDGTLRAAVG
RTHGTRALEI NKMISFWRNA HKRISSQMVV WLKKGELPRA VTRHPDYNEE DDYGAILPQV
VTAGTITRRA VEPTWLTASN ARADRVGSEL KAMVQVPPGY SLVGADVDSQ ELWIAAVLGE
AHFAGMHGCT AFGWMTLQGK KSNATDLHSK TAATVGISRE HAKIFNYGRI YGAGQPFAER
LLMQFNHRLT QQQAREKAQQ MYAVTKGVRR FLLSEEGEWL VRELDLAVDR AEDGSVSLQD
VQRLQREATK RSRTKKKWDV VEHRVWAGGT ESEMFNKLES IALSPSPQTP VLGCHISRAL
EPAVAKGEFL TSRVNWVVQS SAVDYLHLML VAMKWLFEEF DINGRFCISI HDEVRYLVQH
QDRYRAALAL QITNLLTRCM FAYKLGLQDL PQSVAFFSAV DVDQCLRKEV TMNCTTPSNP
TGMEKKYGIP QGEALDIYQL IEITKGSLEK K
//
