ID A0A1V4JJL2_PATFA Unreviewed; 891 AA.
AC A0A1V4JJL2;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 28.
DE SubName: Full=Endothelial PAS domain-containing protein 1 isoform C {ECO:0000313|EMBL:OPJ72379.1};
GN Name=EPAS1 {ECO:0000313|EMBL:OPJ72379.1};
GN ORFNames=AV530_018812 {ECO:0000313|EMBL:OPJ72379.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ72379.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ72379.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ72379.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ72379.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ72379.1}.
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DR EMBL; LSYS01007194; OPJ72379.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4JJL2; -.
DR STRING; 372326.A0A1V4JJL2; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:InterPro.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005667; C:transcription regulator complex; IEA:InterPro.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0046983; F:protein dimerization activity; IEA:InterPro.
DR CDD; cd19728; bHLH-PAS_HIF2a_PASD2; 1.
DR CDD; cd00130; PAS; 2.
DR Gene3D; 3.30.450.20; PAS domain; 2.
DR InterPro; IPR011598; bHLH_dom.
DR InterPro; IPR014887; HIF-1_CTAD.
DR InterPro; IPR021537; HIF_alpha-like.
DR InterPro; IPR036638; HLH_DNA-bd_sf.
DR InterPro; IPR001067; Nuc_translocat.
DR InterPro; IPR001610; PAC.
DR InterPro; IPR000014; PAS.
DR InterPro; IPR035965; PAS-like_dom_sf.
DR InterPro; IPR013655; PAS_fold_3.
DR NCBIfam; TIGR00229; sensory_box; 1.
DR PANTHER; PTHR23043:SF8; ENDOTHELIAL PAS DOMAIN-CONTAINING PROTEIN 1; 1.
DR PANTHER; PTHR23043; HYPOXIA-INDUCIBLE FACTOR 1 ALPHA; 1.
DR Pfam; PF11413; HIF-1; 1.
DR Pfam; PF08778; HIF-1a_CTAD; 1.
DR Pfam; PF08447; PAS_3; 1.
DR Pfam; PF13426; PAS_9; 1.
DR PRINTS; PR00785; NCTRNSLOCATR.
DR SMART; SM00353; HLH; 1.
DR SMART; SM00086; PAC; 1.
DR SMART; SM00091; PAS; 2.
DR SUPFAM; SSF47459; HLH, helix-loop-helix DNA-binding domain; 1.
DR SUPFAM; SSF55785; PYP-like sensor domain (PAS domain); 2.
DR PROSITE; PS50888; BHLH; 1.
DR PROSITE; PS50112; PAS; 2.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW Biological rhythms {ECO:0000256|ARBA:ARBA00023108};
KW Hydroxylation {ECO:0000256|ARBA:ARBA00023278};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Ubl conjugation {ECO:0000256|ARBA:ARBA00022843}.
FT DOMAIN 14..67
FT /note="BHLH"
FT /evidence="ECO:0000259|PROSITE:PS50888"
FT DOMAIN 92..156
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT DOMAIN 269..320
FT /note="PAS"
FT /evidence="ECO:0000259|PROSITE:PS50112"
FT REGION 1..23
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 479..508
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 794..815
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT MOD_RES 423
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT MOD_RES 551
FT /note="4-hydroxyproline"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
FT MOD_RES 868
FT /note="(3S)-3-hydroxyasparagine"
FT /evidence="ECO:0000256|PIRSR:PIRSR621537-50"
SQ SEQUENCE 891 AA; 99188 MW; 4FE35BB716E9C0CE CRC64;
MTADKEKKRS SSERRKEKSR DAARCRRSKE TEVFYELAHE LPLPHNISSH LDKASIMRLA
ISFLRTHKLL SSVCADNENE LEADQQMDNL YLKALEGFIA VVTQDGDMIF LSENVNKYMG
LTQVELTGHS IFDFTHPCDH EEIRENLSLK NVLGLSSTNH SSTVHASLMV SAGPGFGKKS
KEMSTERDFF MRMKCTVTNR GRTVNLKSAT WKVLHCTGQV KVYNTCPPHT LCGYKEPLLT
CLIIMCEPIQ HPSNIDIPLD SKTFLSRHSM DMKFTYCDDR ITDLIGYHPE ELLGRSAYEF
YHALDSESMT KSHQNLCTKG QVVTGQYRML AKHGGYVWLE TQGTVIYNTR NLQPQCIVCV
NYVLSEIEKN DIVFSMDQTE SLFKPHLLTM STAYESGIPG TEKSDFLFTK LKEEPEELAQ
LAPTPGDAII SLDFDLHAGT QKFEEAPAFT TAVLTPNKVW PAEGKSHAAQ GETLTIPSFT
MPQIAPGSST PSASSNSSCS TPSSPGDYYN SVDEDFKIEV IEKLFAMDTE SKNQCNSQTD
FNELDLETLA PYIPMDGEDF QLSPICQEER PLSESAQNTQ QSLSSMSSIF QPLASASQDQ
FPPEKYCSQI SNKNMNPGHG SLSSVFFNNV SRSSLPPYHH QASTPLSSMG GRPNTQWPPD
PPLEYVPAKW RLMDKYSGSL SSSPSGPPIH SHSMPIYKKM PLDAFGQRGI GINPARIALS
NSLKLKRQLD YEEQALQQLS GGDPSVINPS HLMWKRMKFL KGENCSLVTE KKALSTSILT
DEFVCNSRGL SQTMNQLQQQ QQPPPPTCGS PGENLKAGAF PPSFYSSQYQ DYSVQPAHKT
SGMTSRLLGP SFEPYLLPEL TRYDCEVNVP VLGSSTLLQG SELLRALDQA T
//
