ID A0A1V4JKX3_PATFA Unreviewed; 1354 AA.
AC A0A1V4JKX3;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=Ryanodine receptor 2 isoform A {ECO:0000313|EMBL:OPJ72695.1};
GN Name=RYR2 {ECO:0000313|EMBL:OPJ72695.1};
GN ORFNames=AV530_005224 {ECO:0000313|EMBL:OPJ72695.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ72695.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ72695.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ72695.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ72695.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ72695.1}.
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DR EMBL; LSYS01006902; OPJ72695.1; -; Genomic_DNA.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0005219; F:ryanodine-sensitive calcium-release channel activity; IEA:InterPro.
DR GO; GO:0006874; P:intracellular calcium ion homeostasis; IEA:InterPro.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR013662; RIH_assoc-dom.
DR InterPro; IPR015925; Ryanodine_IP3_receptor.
DR InterPro; IPR009460; Ryanrecept_TM4-6.
DR PANTHER; PTHR46399; B30.2/SPRY DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR46399:SF7; RYANODINE RECEPTOR 2; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR Pfam; PF08454; RIH_assoc; 1.
DR Pfam; PF06459; RR_TM4-6; 1.
DR SUPFAM; SSF47473; EF-hand; 1.
DR PROSITE; PS50222; EF_HAND_2; 1.
PE 4: Predicted;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000313|EMBL:OPJ72695.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 666..685
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 887..907
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 961..980
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1097..1118
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1155..1176
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 1231..1254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 409..444
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT REGION 722..752
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 804..855
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 726..744
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 806..855
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1354 AA; 156059 MW; 2A1175DEF748FEE2 CRC64;
MAPLYNLPRH RAVNLFLQGY DKSWIETEEH YFEDKLIEDL AKPGEEPPEE DESLKRVDPL
HQLILLFSRT ALTEKCKLEE DFLYMAYADI MAKVTGSQRS KEKEMEKQKL LYQQARLHDR
GAAEMVLQTI SASKGEMGPM VAATLKLGIA ILNGGNSTVQ QKMLDYLKDK KDVGFFQSLA
GLMQSCSVLD LNAFERQNKA EGLGMVTEEG SGEKVMQDDE FTCDLFRFLQ LLCEGHNSDF
QNYLRTQTGN NTTVNIIIST VDYLLRVQES ISDFYWYYSG KDVIDEQGQR NFSKAIQVAK
QVFNTLTEYI QGPCTGNQQS LAHSRLWDAV VGFLHVFAHM QMKLSQDSSQ IELLKELMDL
QKDMVVMLLS MLEGNVVNGT IGKQMVDMLV ESSNNVEMIL KFFDMFLKLK DLTSSDAFKE
YDPDGKGVIS KRDFHKAMES HKHYTQSETE FLLSCAETDE NETLDYEEFV KRFHEPAKDI
GFNVAVLLTN LSEHMPHDSR LQTFLELSES VLNYFQPFLG RIEIMGSAKR IERVYFEISE
SSRTQWEKPQ VKESKRQFIF DVVNEGGEKE KMELFVNFCE DTIFEMQLAA QISESDLNER
SANKEENERD KPEEQDPRIG FFSLMTMKSA LVALKYNIVT LMKMLSMKSL KKQMKKVKKM
TMKDMVMALF SSYWSILMGL LHFAYSVVRG FFRIICSLLL GGSLVEGAKK IKVAELLANM
PDPTQDEVRG EGEEGERKPT EAALPTEDLT DLRTLSDESD LLSDIFGLDL KREGGQYKLI
PHNPNAGLSD LLSTPSIAPM PEVQEKVQEQ VKEDEKEEKE ETKSEPEKAE GEDGEKEEKA
KEDKGKQKLR QLHTHRYGEP EVQESAFWKK IIAYQQKLLN YFARNFYNMR MLALFVAFAI
NFILLFYKVS TSAVTEEKDI PVVSADESTK LDSLESDNQR VIAVHYVLEE SSGYMEPTLR
ILAILHTVIS FFCIIGYYCL KVPLVIFKRE KEVARKLEFD GLYITEQPSE DDIKGQWDRL
VINTQSFPNN YWDKFVKRKV MDKYGEFYGR DRISELLGMD KAALDFSDAR EKKKPKKDSS
LSAVLNSIDV KYQMWKLGVV FTDNSFLYLA WYMTMSVLGH YNNFFFAAHL LDIAMGFKTL
RTILSSVTHN GKQLVLTVGL LAVVVYLYTV VAFNFFRKFY NKSEDGDMPD MKCDDMLTCY
MFHMYVGVRA GGGIGDEIED PAGDEYEIYR IIFDITFFFF VIVILLAIIQ GLIIDAFGEL
RDQQEQVKED METKCFICGI GNDYFDTVPH GFETHTLQEH NLANYLFFLM YLINKDETEH
TGQESYVWKM YQERCWEFFP AGDCFRKQYE DQLN
//
