ID A0A1V4JMQ7_PATFA Unreviewed; 6061 AA.
AC A0A1V4JMQ7;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 26.
DE SubName: Full=Dystonin isoform C {ECO:0000313|EMBL:OPJ73440.1};
GN Name=DST {ECO:0000313|EMBL:OPJ73440.1};
GN ORFNames=AV530_005792 {ECO:0000313|EMBL:OPJ73440.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ73440.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ73440.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ73440.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ73440.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SUBCELLULAR LOCATION: Cytoplasm, cytoskeleton
CC {ECO:0000256|ARBA:ARBA00004245}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ73440.1}.
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DR EMBL; LSYS01006902; OPJ73440.1; -; Genomic_DNA.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005856; C:cytoskeleton; IEA:UniProtKB-SubCell.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0008017; F:microtubule binding; IEA:InterPro.
DR GO; GO:0045104; P:intermediate filament cytoskeleton organization; IEA:InterPro.
DR CDD; cd00051; EFh; 1.
DR CDD; cd00176; SPEC; 17.
DR Gene3D; 1.20.58.60; -; 27.
DR Gene3D; 1.10.238.10; EF-hand; 1.
DR Gene3D; 3.30.920.20; Gas2-like domain; 1.
DR Gene3D; 3.90.1290.10; Plakin repeat; 2.
DR InterPro; IPR011992; EF-hand-dom_pair.
DR InterPro; IPR018247; EF_Hand_1_Ca_BS.
DR InterPro; IPR002048; EF_hand_dom.
DR InterPro; IPR003108; GAR_dom.
DR InterPro; IPR036534; GAR_dom_sf.
DR InterPro; IPR043197; Plakin.
DR InterPro; IPR035915; Plakin_repeat_sf.
DR InterPro; IPR001101; Plectin_repeat.
DR InterPro; IPR018159; Spectrin/alpha-actinin.
DR InterPro; IPR002017; Spectrin_repeat.
DR PANTHER; PTHR23169; ENVOPLAKIN; 1.
DR PANTHER; PTHR23169:SF21; EPIPLAKIN; 1.
DR Pfam; PF13499; EF-hand_7; 1.
DR Pfam; PF02187; GAS2; 1.
DR Pfam; PF00681; Plectin; 4.
DR Pfam; PF00435; Spectrin; 19.
DR SMART; SM01129; DELLA; 1.
DR SMART; SM00054; EFh; 2.
DR SMART; SM00243; GAS2; 1.
DR SMART; SM00250; PLEC; 10.
DR SMART; SM00150; SPEC; 30.
DR SUPFAM; SSF47473; EF-hand; 1.
DR SUPFAM; SSF143575; GAS2 domain-like; 1.
DR SUPFAM; SSF75399; Plakin repeat; 2.
DR SUPFAM; SSF46966; Spectrin repeat; 26.
DR PROSITE; PS00018; EF_HAND_1; 2.
DR PROSITE; PS50222; EF_HAND_2; 2.
DR PROSITE; PS51460; GAR; 1.
PE 4: Predicted;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Cell projection {ECO:0000256|ARBA:ARBA00023273};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Cytoskeleton {ECO:0000256|ARBA:ARBA00023212};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 5717..5752
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 5753..5788
FT /note="EF-hand"
FT /evidence="ECO:0000259|PROSITE:PS50222"
FT DOMAIN 5793..5865
FT /note="GAR"
FT /evidence="ECO:0000259|PROSITE:PS51460"
FT REGION 905..1043
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1095..1187
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1587..1606
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 3586..3610
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5630..5650
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5889..5950
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 5972..6061
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 2124..2154
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2242..2301
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2406..2437
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 2792..2894
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3077..3104
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3291..3352
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 3733..3795
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4714..4741
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4830..4864
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 4977..5004
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 5475..5502
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 914..955
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 976..1006
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1095..1132
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1150..1187
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 3586..3608
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5901..5936
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 5977..5998
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 6005..6031
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 6061 AA; 684208 MW; B95CE530062BB4ED CRC64;
MEEEKKEHVE KAGDLLKWVS NLSKTLSKEG GEKAEKTDMP KQQISLDEMS TKKEQIAEAL
QTTQSFLAKH SDKMTDEERN EMEKQVRSLQ ESYSLLSNEA LKQLQEEQYL GDEKIEEKVN
KVIAGVIDQT TGQVLSVFQS ILKGFIDYDT GIRLLENQLI LSGIISPELG VCYDLEEAKA
HGLIDEQTVS QLQELSRAKK LISESTLSNI PVVSALEQGL ISEPLAIKIL ENQLSSGPLI
LPSTGENLTL QTAFQRNLIT PTLYKKLLER QDTCKDLIDP NCAEKISLEE MLHRSIIHEE
TGLRLLPVKP QEKGRIVFKC GRKITILRAA HEGLIDRETM FRLLGAQLMS GGLIDPDSGK
QMTVEEAMRQ GLIDQDTACG ILTHQVQTGG ILCPNSGERL TVDEAVQCNL ISSTSALLVL
EAQRGFVGLI FPHTGEIFPI STSLHQEMIT NELAFKILNN RQKIAALYIP ETCEIVSLDE
AAQSGILDIN TVSVLTNVTL PDEMPNVEEL ESPCKNAARW LSIYEFLPSV CRDHEEEHED
SGTEGPVCHN LDQAKKLFIS YLMVNSYMDA NTGGRLLLYD GQLQEAINML LKGDGAACNA
DVSEMEFHNT CISPKGRNLK SAGSVHFNSV MGTVQGDRSG AENVSNNRQL NQSEDLGNYI
SLQGEDLHVC RPGVCNAIGT EQSEYTQLST NPTEFRKVAS STQNSMNRNA LRGFLEVSEW
AELCKHNKQK ANSENFEGYL PNDANPNLIS ETEEETCMAD SLCNEKRNDK TLQNSLGVND
LSDNETWREL ERCTKYEPHI QQAENSTAIL DSSKKEDFQR SLGSCVSADT KCILPEELVH
LCGDMLQFED NGSSEQPLQD YTDLHNRPSL EEYLYIHGRP SLEDYSDLQS KLCLEDSGDM
HCSPLLDGDT VIQSGPPVGN SNSMAQGLAA EESTQFSQLL PCDSSSDSSV DGNDGIPQFE
RNCLQHECGE VTSEDSSSQF DDDDNDAYET PQVGDDDSDV YDTPQIDDDD SYGTPQGDDG
VDALHLGDDD TPEPELSRTS VPLGFLEEKS GLITLREDTS SFQELATNAG EGVHVNVTGP
TESINIASAS VEAVEGIPEK ERERTGSFGE KEKKLPVTLE TEGRKEEVLT SLQKKYEAQV
QNRNEEDEMK PESDSDEDES EGTWEEEDYE EVYDSYDDSD TDSDSDEEMG VFNAHHQCIN
KGDQLLISLG DIEDDNENNQ NIDDCCYPSG HKTGYTLQFQ SNYENGKLSS GKCEFAVGVP
EERCIGLTNE EDRQQQTENK YGTCIKSKRM SEDTTGPIQS ENIFDTKWMS RKCEENNKAL
PNVPGSQLLN DTVTSDIGTA AFLITKNPTD DDESTRTSSS QMDSKFLMDM PYVSDGDSSL
SDQVHPLNSR KCDQIGRDFE IPTENKARVN IMEECDIMGL SGSPIQMESL GEIFDASVIK
ADGETPVSSK EKANVDQALL NVGGDVEIGE LKRDFNVSAS LKVYTTDIKE SGHSELVKTE
SCCFEDRERG EKGIQNEKDF LLNMDEMHSS EFNTYSVPST DRVKPKEMSV TKETGRVICQ
NTNNVLEGFS ENKSNNDTEF SPVKANASGS IEDAKESGEG SVPLKNTKGE NVMACETPSL
GNGFEKQRSM ESLEKEMAPC KDFQVNECIS QSPEMSDTLM EDLKNVLQRK LKMGHVCKQE
GEPLSYSDTK ILMESLLKMV RSTQLGSDLS SESNLKQISN AVRTALTVTM PCPQPKDSDA
LSSLWPDCRS PDLLRDILKQ ESCKQNMNDP SERKSETGVK ASLPKLPASD LLEIFQISPG
AESTSKLEEL ISGLFTSSQV AGIATEQEGK GKVDGLCTLF STEQSEFGSE IAKEKTLAAD
TDFAWKSDQE LGKTESLAKG FTEPLLETKA AILGDTPPST VDEVQQCLKL TEKMQEHLAV
LQDMKSQLDN QQPISNNLEI LKDELEQLES FESGLATFAI ILKKDMKLTE EFLKFCHRDI
PEEKLKELKI SYDCLREAFL VVCETSSKRA KQIVCAVDLE MSKLAVSHQQ LLSKLQRFSD
WIAENHETVN DFIVNTNGIE EIKKSLQLLK NSAAELGSKK MQLESTAFDV QFFISEHAQD
LSPNQSKQLL RLLNTTQKSF QEVQEAIISQ VETLEAQLQA AQELGDQKDV AERQQECKEK
LQEICDLLTQ TENRLIGQRE SLVIGDSKAE LQQYQTKQEE IQKDMRMSAQ TLAEIVKNTE
TFLKENGEKL SQEDKTVLEQ KLNEAKTKCL LLSQKAEESK KELDKAMTTA IKQETEKVAA
IEQLEESKNT IENLLDWLSN VDKEAEHGRK FKQAIEQNGT HFEEGDVKVL EGEEDDVNGN
LLEMEDIETQ VDGLVKSTED NLNQQYQKVK AQHEKIISQQ QAVIIATQSA QALLEKQGHH
LSPEEKDKMQ RNMKELKAQY EAALAESERK MKLTRSLREE LEKFDADYSE FEIWLQQAEQ
ELGNLEAGAS DFSGIMVKLK RQKSFSEDVI SHKGDLRYIT ISGQRVLDAA RSCSKRDGVK
VDKDGIDTSA TYAEVQNKLD SASDRFKSLY TQCSILGNNL KDLVDKYQHY EDASSGLLSG
LQASEIAVNK QLSEPIAVDP KNLQRQLEET KILQGQVSNH QIAVEKLKKA AEVLLDTRGE
LTPDKDEIQK TLDDIVERYD NLSKSVNDRN EKLQITLTRS LSVQDGLDEM LDWMEGVEKS
LEEHDQVPLN SSAIQDIISK SIMLEQDIAG RQSSINTMNE KVKKFMETAD PSTASTLQAK
MSELAGRFSE ASNKHKAKLM KMEELKTKVE LFEDLSEKLQ SFLDEKNQAL SETEAPRKDV
SEVSQYMQEA SVELAQHKKD LEVLQQLLEE LSFHALPGDK ALVLEKVNAL SKKFREVEET
VKEKEEDVLS CQKQMDDFEL LVESLKKWIK EMTERIPAAQ PSLNTEELKK PLEDTLNLKD
EWTSKAPELQ KMNSRGTLLC NLITAVTSPA KLRAVAKSGG TMLNGEGGAP GTHDFLKNKE
LTAVQQAMSD VNHSYEDLGV LLKEKISELE SMLSKMQNIQ EESSSMMQWL QKMDKTASDW
EAAPTDSEAV KAQVEQHKLF ETELKQSANK VQELKDKVTE LLEKNPDSPE APKWRQMLDK
IDSKWKELNQ VTSERQQKLE ESSNYLTQFQ TAEAQLKHWL VEKELMVSVL GPLSIDPNML
NTQKQQVQIL LQEFDTRKPQ YEQLTMAGEG ILKRPGEHLP SHEIVKEQLA AVAQKWDSLT
GQLRNRCDRI DQAIVKSTEY QSLLRSLSDK LSALDSKLSS SLAVSTQPDA VKQQLEIARE
MKEEIEQEMK NINAAQALCE ELSALVEEEY LKAELTRQLD GILKLFKDIE QKSDNHVQQL
QSVYATSHQF QQMSKDFQTW LCKKKEELNQ AHPVSAKLDV LQSLIEEQKD FKKTMTDQIS
SYERIVAEGE SILQKTQGAD KAALQSQIAT LRSNWDEMNN QVKERQDRLT DCLEKALKYK
QHVENLQPWI EKCQSNLCEL KVGVNPVEIE NSIVQVRAWQ KDLDKHHGIV ELLNNTAESL
LSASQTDKEI VQEETKVLNQ KVNVVTEQLH KKRECLENTA QRLKEFQEST RETEKQLKST
KEHLEAHDSL GPQSFSSKHL TMMQAQQKAL QALKPHVDLA KKLAQDLVVE ASDSAGVSDL
LIQAESLEQE YTAVNQQVED RCSFLETKLQ GIGHFQNSIR EMFSQFAEFD DELDSMAPVG
RDLKVLQSQR EDIKCFLKKL EDLIMNNENA NKNCKMMLAT EAEASPDLVG IKRDLEALNK
QCNKLLDRAK AREDQVESTT SRVEEFYSKL KAFSSLLGRA EEHEESQGPV GMETETINQQ
LDTFKVFQKE EIEPLQVKQQ EVNWLGQGLI QSAAKSTNTE NLEHDLEDVN TRWKTLNKKV
AQRAAQLQEA LLHCGRFQDA LESLLSWLID TEDLVANQKP PSAEFKVVKA QIQEQKLLQR
LLDDRKPTVE VIKREGEKIA ESAEPADRVK ILKQLSFLDS RWDALLNKAE TRNRQLEGIS
VVAQQFHEAL EPLVEWLTAT EKRLANAEPI GTQASKLEQQ ISQHKALEDD VLAHSKSLHQ
AISTGQTLKT MSSREDKDMV QEKLDSSQAR YIEIQEKSNS RSELLQQAYS NAQIFGEDEV
ELMNWLNEVH DKLSKLSVQD CNTELLEKQH SELLDLQEEI LLRKQNVDLA IQNGLELLKQ
TTGDEVVIIQ DKLEGIKARY KDITKLCSDV SKTLEQALQL AGQLHPTHEQ LCKWLDEVEV
ELLSYETQLP TGEELSQVQE RQKELKKEAK NNKGLLDTLN EVGSAFLELV PWRAREGLDK
MITEDNERYR LVSDRIAQKV DEIDAAILRS QQFDQAADAE FAWIAETEKK LMSLGDIRLE
QDQTTTQLQV QKAFTMEILR HKDIIDELVK SGDKIMNTCT EEEKQTMKKK MESLLQKYDA
VCQMNSERNL QLERAQSLVN QFWETYEELW PWLTETEMII SQLPAPALEY ETLKQQQEEH
RQLRELIAEH KPHIDKMNKT GPQLLELSPG EGFSIQEKYV AADTLYSKIK EDVKKRALAL
DEAISQCTQF HDKIDPTLES LKRIVERLRQ PPSISAEVEK IKEQISENKN VSVDLEKLQP
VYETLKQRGE EMIARSEGAD KDISAKAVQD KLDQMVLIWG DIQTLTEERE AKLLDVMELA
EKFWCDHMAL VATIKDTQDF VRELEGPGVD PSVVKQQQEA TEAVKEEIDG LQEELEAVVS
LGSELRAACG EPDKPIVNKS IDELNSAWDA LNKTWKERVD KLVEAMQAAV QYQDGLQAIF
DWVDIAGSKL ASMSPVGTDL ETVKQQTEEL KQFKTEAYQQ QIEMERLNHQ AELLLKKVTE
ESDKHTVQDP LSELKLMWDT LEEKIINRQH KLEGALLALG QFQHALDELL TWLTHTEDLL
NEQKPVGGDP KAIEIELAKH HVLQNDVLAH QSTVEAVKKA GNDLMESSAV EEASNLRSKL
ELLNQHWQNV LEKTEQRKQQ LDSALIQAQG FHGEVEDLQQ WLTDTERQLL ASKPVGGLPE
TAREQLNTHM ELCAAFEAKE ETYKCLMQKG QQMLARCPES AETNVEQDIN NLKEKWESVQ
TKLGERKTKL EEALNLAMEF HNSLQDFINW LTQAEQTLTA ASRPSLILDT VLFQIDEHKV
FATEVNSHRD QIIELDKTGT HLKYFSQKQD VVLIKNLLIS VQSRWEKVVQ RLVERGRALD
DARKRAKQFH DAWHKLMEWL EESEKSLDSD LEIANDPDKI KMQLAQHKEF QKSLGAKHSV
YDTTNRTGRS LKEKTTLADD NLKLDDMLSE LRDKWDTICG KSVERQNKLE EALLFSGQFT
DALQALIDWL YKIEPQLAED QPVHGDIDLV MNLIDNHKVF QKELGKRTSS VQALKRSARE
LIEGSRDDSS WVKVQMQELS TRWETVCALS VSKQTRLEQA LRQAEEFHSV VHVLLEWLAE
AEQALRFHGV LPDDEEALRT LIDQHREFMK KLEEKKAELN KATGMGEAIL AICHPDSITT
IKHWITIIRA RFEEVLAWAK QHQQRLAGAL AGLIANQELL EALLSWLQWA ETTLTEKDKE
IIPQEIEEVK ALIAEHQTFM EEMTRKQPDV DKVTKTYKRK ALEPSPVQSH IPVLDKGRTG
RKRSPTPGIY PSAAQAQIET KNPRVNLLVS KWQQVWLLAL ERRRKLNDAL DRLEELREFA
NFDFDIWRKK YMRWMNHKKS RVMDFFRRID KDQDGKITRQ EFIDGILSSK FPTSRLEMSA
VADIFDRDGD GYIDYYEFVA ALHPNKDAYK PLTDADKIED EVTRQVAKCK CAKRFQVEQI
GDNKYRFGDS QQLRLVRILR STVMVRVGGG WMALDEFLVK NDPCRAKGRT NVELREKFIL
ADGASQSMAA FRPRGRRSRP SSRGASPNRS TSLSSQAGQA ASPQAVATST PKGTPIQGSK
LRMPGYLSGK GFHSGEDSGI LSTAATRVRA QFAETRKTPS RPGSRAGSKA GSRSSSRRGS
DASDFDISEI QSVCSDMSET VPATSRPTPR AGSRPGSAKP SKIPTPQRRP LASKLDKSLK
R
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