ID A0A1V4JRR7_PATFA Unreviewed; 1298 AA.
AC A0A1V4JRR7;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 20.
DE RecName: Full=1-phosphatidylinositol 4-kinase {ECO:0000256|ARBA:ARBA00012169};
DE EC=2.7.1.67 {ECO:0000256|ARBA:ARBA00012169};
GN Name=PI4KA {ECO:0000313|EMBL:OPJ74851.1};
GN ORFNames=AV530_018363 {ECO:0000313|EMBL:OPJ74851.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ74851.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ74851.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ74851.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ74851.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the PI3/PI4-kinase family. Type III PI4K
CC subfamily. {ECO:0000256|ARBA:ARBA00006209}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ74851.1}.
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DR EMBL; LSYS01006629; OPJ74851.1; -; Genomic_DNA.
DR STRING; 372326.A0A1V4JRR7; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0016301; F:kinase activity; IEA:UniProtKB-KW.
DR GO; GO:0046854; P:phosphatidylinositol phosphate biosynthetic process; IEA:InterPro.
DR GO; GO:0016310; P:phosphorylation; IEA:UniProtKB-KW.
DR CDD; cd00871; PI4Ka; 1.
DR CDD; cd05167; PI4Kc_III_alpha; 1.
DR Gene3D; 1.10.1070.11; Phosphatidylinositol 3-/4-kinase, catalytic domain; 1.
DR Gene3D; 1.25.40.70; Phosphatidylinositol 3-kinase, accessory domain (PIK); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR000403; PI3/4_kinase_cat_dom.
DR InterPro; IPR036940; PI3/4_kinase_cat_sf.
DR InterPro; IPR018936; PI3/4_kinase_CS.
DR InterPro; IPR001263; PI3K_accessory_dom.
DR InterPro; IPR042236; PI3K_accessory_sf.
DR InterPro; IPR045495; PI4K_N.
DR InterPro; IPR015433; PI_Kinase.
DR PANTHER; PTHR10048:SF15; PHOSPHATIDYLINOSITOL 4-KINASE ALPHA; 1.
DR PANTHER; PTHR10048; PHOSPHATIDYLINOSITOL KINASE; 1.
DR Pfam; PF00454; PI3_PI4_kinase; 1.
DR Pfam; PF00613; PI3Ka; 1.
DR Pfam; PF19274; PI4K_N; 1.
DR SMART; SM00145; PI3Ka; 1.
DR SMART; SM00146; PI3Kc; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS00915; PI3_4_KINASE_1; 1.
DR PROSITE; PS00916; PI3_4_KINASE_2; 1.
DR PROSITE; PS50290; PI3_4_KINASE_3; 1.
DR PROSITE; PS51545; PIK_HELICAL; 1.
PE 3: Inferred from homology;
KW Kinase {ECO:0000256|ARBA:ARBA00022777, ECO:0000313|EMBL:OPJ74851.1};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW Transferase {ECO:0000256|ARBA:ARBA00022679}.
FT DOMAIN 726..914
FT /note="PIK helical"
FT /evidence="ECO:0000259|PROSITE:PS51545"
FT DOMAIN 1004..1282
FT /note="PI3K/PI4K catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50290"
SQ SEQUENCE 1298 AA; 147651 MW; 770821EAE262FD5E CRC64;
MGFAVEGSGL WPEEWYEGVC EIATKSPLLT FPSKEPLRSV LQYNSAMKND TVTSAELNEL
RSTIINLLDP PPEVSALINK LDFAMSTYLL SVYRLEYMRV LRSTDQDRFQ VMFCYFEDKA
IQKDKSGMMQ CVIAVADKVF EAFLTMMADK PKTKENEEEL ERHAQFLLVN FNHIHKRIRR
VADKYLSGLV DKFPHLLWSG TVLKTMLDIL QTLSLSLSAD IHKDQPYYDI PDAPYRITVP
DTHEARESIV KDFAARCGMI LQEAMKWAPS VTKSHLQEYL NKHQNWVSGL SQHTGLAMAT
ESVLHFAGYN RQNTTLGATQ LTERPTCVKK DYSNFMASLN LRNRYAGEVS GMIQFSNATG
RTSDLNKLMV KELNDALELG HAEFYTQAMF KLTALLISSK DCDPQLLHHL CWGPLRMFNE
HGMETAIACW EWLLAAKNGI EVPFMREMAG AWQMTVEQKV GLFSAEQKEA DPLAASEESQ
PRPCPPEVTP HYIWIEFLVQ RFEIAKYCSS DQIEIFSSLL QRSLSLNIGG AKGSLNRHVA
AIGPRFKLLT LGLSLLHADV VPNATIRNVL REKIYSTAFD YFSCPSKFPT QGEKRLREDI
SILIKFWTAM FSDKKYLTAS QLVPPDNQDT RSNLDINVGS RQQATQGWIN TYPLSSGMST
ISKKSGMSKK TNRGTQLHKY YMKRRTLLLS LLATEIERLI TWYNPLSSPE LELDQTGESS
VANWRSKYVS LSEKQWKDNV NLAWSISPHL AVQLPTRFKN TEAIGTEVTR LVRLDPGAVS
DVPEAIKYLV TWHTIDADAP ELSHVLCWAP TDPPTGLSYF SSMYPPHPLT AQYGVKVLRS
FPPDAILFYI PQIVQALRYD KMGYVREYIL WAASKSQLLA HQFIWNMKTN IYMDEEGHQK
DPDIGELLEQ LVEEITGSLS GPAKEFYQRE FDFFNKITNV SAIIKPFPKG DERKKACLSA
LSEVKVQPGC YLPSNPEAIV LDIDYKSGTP MQSAAKAPYL AKFKVKRCGV SELEKEGLRC
RSDSIDESAE EGVDSRKICW QAAIFKVGDD CRQDMLALQI IDLFKNIFQL VGLDLFVFPY
RVVATAPGCG VIECIPDCTS RDQLGRQTDF GMYDYFTRQY GDESTLAFQK ARYNFIRSMA
AYSLLLFLLQ IKDRHNGNIM LDKKGHIIHI DFGFMFESSP GGNLGWEPDI KLTDEMVMIM
GGKMEATPFK WFMEMCVRGY LAVRPYMDAV VSLVTLMLDT GLPCFRGQTI KLLKHRFSPN
MTEREAATFI IKIIQNCFLS NRSRAYDMIQ YYQNDIPY
//
