ID A0A1V4JV90_PATFA Unreviewed; 1081 AA.
AC A0A1V4JV90;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE SubName: Full=Solute carrier family 12 member 7 {ECO:0000313|EMBL:OPJ76112.1};
GN Name=SLC12A7 {ECO:0000313|EMBL:OPJ76112.1};
GN ORFNames=AV530_015415 {ECO:0000313|EMBL:OPJ76112.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ76112.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ76112.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ76112.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ76112.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=chloride(in) + K(+)(in) = chloride(out) + K(+)(out);
CC Xref=Rhea:RHEA:72427, ChEBI:CHEBI:17996, ChEBI:CHEBI:29103;
CC Evidence={ECO:0000256|ARBA:ARBA00034453};
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the SLC12A transporter family.
CC {ECO:0000256|ARBA:ARBA00010593}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ76112.1}.
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DR EMBL; LSYS01006073; OPJ76112.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4JV90; -.
DR STRING; 372326.A0A1V4JV90; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0015379; F:potassium:chloride symporter activity; IEA:InterPro.
DR Gene3D; 1.20.1740.10; Amino acid/polyamine transporter I; 1.
DR InterPro; IPR004841; AA-permease/SLC12A_dom.
DR InterPro; IPR000076; KCL_cotranspt.
DR InterPro; IPR018491; SLC12_C.
DR InterPro; IPR004842; SLC12A_fam.
DR NCBIfam; TIGR00930; 2a30; 1.
DR PANTHER; PTHR11827:SF47; SOLUTE CARRIER FAMILY 12 MEMBER 7; 1.
DR PANTHER; PTHR11827; SOLUTE CARRIER FAMILY 12, CATION COTRANSPORTERS; 1.
DR Pfam; PF00324; AA_permease; 2.
DR Pfam; PF03522; SLC12; 2.
DR PRINTS; PR01081; KCLTRNSPORT.
PE 3: Inferred from homology;
KW Chloride {ECO:0000256|ARBA:ARBA00023214};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Potassium {ECO:0000256|ARBA:ARBA00022958};
KW Potassium transport {ECO:0000256|ARBA:ARBA00022538};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW Symport {ECO:0000256|ARBA:ARBA00022847};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022847}.
FT TRANSMEM 115..138
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 150..173
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 194..215
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 250..267
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 274..293
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 413..433
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 453..479
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 499..517
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 553..571
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 577..599
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 611..635
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 121..296
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 414..692
FT /note="Amino acid permease/ SLC12A"
FT /evidence="ECO:0000259|Pfam:PF00324"
FT DOMAIN 706..823
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT DOMAIN 822..1081
FT /note="SLC12A transporter C-terminal"
FT /evidence="ECO:0000259|Pfam:PF03522"
FT REGION 1..49
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 15..42
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1081 AA; 120418 MW; 50504D22D0D1FCAF CRC64;
MPTSFTVVPV EAQGEERGPA ERDEQWQKVE DDERDRGHGD GIAKESSPFI NSAEVDRGNM
YEGKNMALFE EEMDSNPMVS SLLNKLANYT NLTQGVVEHE ADEDSKRKEV KVPRMGTFIG
VYLPCLQNIL GVILFLRLTW IVGTAGVLES FIIVFMCCAC TMLTAISMSA IATNGVVPAG
GSYYMISRSL GPEFGGAVGL CFYLGTTFAG AMYILGTIEI LLTYISPSAA IFKAEEVGEE
TKAMLNNMRV YGTCIIILMA IVVFVGVKYV NKLALVFLAC VILSIIAIYA GVIKTAFDPP
DFPICLLGNR TLSKRSFDVC AKFTENNNET KTTTLWRLFC DSSLFNATCD DYFSLNNVTE
IQGIPGIMSG VLTDNLWSAY SEKGSLLEKK NQASVAGSEE TKMGGLPYVF TDIMTYFTML
VGIYFPSVTG IMAGSNRSGD LKDAQKSIPT GTILAISTTS LIYLSCIVLF GACIEGVVLR
DKFGEAVNGN LVVATLAWPS PWVIVIGSFF STCGAGLQSL TGAPRLLQAI ARDGIVPFIQ
VFGHGKANGE PTWALLLTAG ICEIGILIAS LDSVAPILSM FFLMCYMFVN LACAVQTLLR
TPNWRPRFKY YHWTLSFLGM SLCLALMFIC SWYYALIAML IAGCIYKYIE YRGAEKEWGD
GIRGLSLNAA RYALLRVEDG PPHTKNWRPQ LLVLLNLDNE QLVKHPRLLS FTSQLKAGKG
LTIVGSVLQG VYLDKCTETQ KAEENVKALM GVEKTKGFCQ IVVSPNFRDG ISYLIQSAGL
GGMKHNTVLM AWPQSWKQTE NRFSWKNFVD TVRETTAAQQ ALLVAKNIDL FPTNQERFTE
GNIDVWWIVH DGGMLMLLPF LLRQHKVWRK CKMRIFTVAQ MDDNSIQMKK DLQMFLYHLR
LNAEVEVVEM FENDISAFTY EKTLMMEQRS QMLKQMQLSK NEREREAQLI HDRNTASHST
PAVKSSVAAA MPEKVQMTWT KEKFVAEKHK NKDLNVTGFK DIFNMKPNRT NVRRMHTAVK
LNGVVLDKSQ HAQLVLLNMP GPPKNRKGDE NYMEFLEVLT EGLDRVLLVR GSGREVITIY
S
//
