ID A0A1V4JVQ5_PATFA Unreviewed; 443 AA.
AC A0A1V4JVQ5;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 18.
DE SubName: Full=CASP8 and FADD-like apoptosis regulator {ECO:0000313|EMBL:OPJ76233.1};
GN Name=CFLAR {ECO:0000313|EMBL:OPJ76233.1};
GN ORFNames=AV530_004013 {ECO:0000313|EMBL:OPJ76233.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ76233.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ76233.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ76233.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ76233.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- SIMILARITY: Belongs to the peptidase C14A family.
CC {ECO:0000256|ARBA:ARBA00010134}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ76233.1}.
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DR EMBL; LSYS01005888; OPJ76233.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4JVQ5; -.
DR STRING; 372326.A0A1V4JVQ5; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR GO; GO:0042981; P:regulation of apoptotic process; IEA:InterPro.
DR CDD; cd08337; DED_c-FLIP_r1; 1.
DR CDD; cd08340; DED_c-FLIP_r2; 1.
DR Gene3D; 3.40.50.1460; -; 2.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 2.
DR InterPro; IPR029030; Caspase-like_dom_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR001875; DED_dom.
DR InterPro; IPR011600; Pept_C14_caspase.
DR InterPro; IPR001309; Pept_C14_p20.
DR InterPro; IPR015917; Pept_C14A.
DR PANTHER; PTHR48169:SF4; CASP8 AND FADD LIKE APOPTOSIS REGULATOR; 1.
DR PANTHER; PTHR48169; DED DOMAIN-CONTAINING PROTEIN; 1.
DR Pfam; PF01335; DED; 2.
DR Pfam; PF00656; Peptidase_C14; 2.
DR SMART; SM00115; CASc; 1.
DR SMART; SM00031; DED; 2.
DR SUPFAM; SSF52129; Caspase-like; 1.
DR SUPFAM; SSF47986; DEATH domain; 2.
DR PROSITE; PS50208; CASPASE_P20; 1.
DR PROSITE; PS50168; DED; 2.
PE 3: Inferred from homology;
KW Apoptosis {ECO:0000256|ARBA:ARBA00022703};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW Repeat {ECO:0000256|ARBA:ARBA00022737}.
FT DOMAIN 6..78
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 97..175
FT /note="DED"
FT /evidence="ECO:0000259|PROSITE:PS50168"
FT DOMAIN 271..320
FT /note="Caspase family p20"
FT /evidence="ECO:0000259|PROSITE:PS50208"
SQ SEQUENCE 443 AA; 50898 MW; C5C7BBA6CDDA3B60 CRC64;
MTRCQVPAVL IHQIEEELDK EEEEMMVFLC RDLAPDLATA DLRELLLALN EREKLSFLGL
CELLYRVKRF DLLRRILKTE KVAVEANLAR SVSLVPDYRA LMLEMNENLE KEEVGSLAFL
LRDYAPRMKM AKDKSFLALV IDLEKLNLVG PDQLDLIESC FRNIHRIDLT RKIQKYKREA
LMSSVHSQPV YVNALQASLP NLSLIDPPYN SGIQNTHRLK SQNGQSLIPA EPVHMSIQES
GPVSQKVFVD QYRMQSQPLG ICLIIDCIGN DTDMLEETFR GLGYDIRCHR YLNTNAMVQT
LLEVARLQKH RNCDSFICVL SYIVPENEQE CTSLLEVDGN DEKSIANAKP PCKVTIPQEA
DIFWSQCKVD ASTLERSGTS SSYYLRCLSE LLRNPHKRKL SILDIHTELN RRVYEWNQTA
DPSQQYSLLL QHTLRKKLFL SPT
//
