ID A0A1V4JY62_PATFA Unreviewed; 856 AA.
AC A0A1V4JY62;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 20.
DE RecName: Full=Origin recognition complex subunit 1 {ECO:0000256|ARBA:ARBA00019081, ECO:0000256|RuleBase:RU365058};
GN Name=ORC1 {ECO:0000313|EMBL:OPJ77084.1};
GN ORFNames=AV530_007496 {ECO:0000313|EMBL:OPJ77084.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ77084.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ77084.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ77084.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ77084.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Component of the origin recognition complex (ORC) that binds
CC origins of replication. DNA-binding is ATP-dependent, however specific
CC DNA sequences that define origins of replication have not been
CC identified so far. ORC is required to assemble the pre-replication
CC complex necessary to initiate DNA replication.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBUNIT: ORC is composed of six subunits.
CC {ECO:0000256|RuleBase:RU365058}.
CC -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123,
CC ECO:0000256|RuleBase:RU365058}.
CC -!- SIMILARITY: Belongs to the ORC1 family. {ECO:0000256|ARBA:ARBA00008398,
CC ECO:0000256|RuleBase:RU365058}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ77084.1}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; LSYS01005497; OPJ77084.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4JY62; -.
DR STRING; 372326.A0A1V4JY62; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0005524; F:ATP binding; IEA:UniProtKB-KW.
DR GO; GO:0016887; F:ATP hydrolysis activity; IEA:InterPro.
DR GO; GO:0003682; F:chromatin binding; IEA:InterPro.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0006260; P:DNA replication; IEA:UniProtKB-KW.
DR CDD; cd00009; AAA; 1.
DR CDD; cd04719; BAH_Orc1p_animal; 1.
DR CDD; cd08768; Cdc6_C; 1.
DR Gene3D; 1.10.8.60; -; 1.
DR Gene3D; 2.30.30.490; -; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR003593; AAA+_ATPase.
DR InterPro; IPR041083; AAA_lid_10.
DR InterPro; IPR003959; ATPase_AAA_core.
DR InterPro; IPR001025; BAH_dom.
DR InterPro; IPR043151; BAH_sf.
DR InterPro; IPR015163; Cdc6_C.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR10763; CELL DIVISION CONTROL PROTEIN 6-RELATED; 1.
DR PANTHER; PTHR10763:SF23; ORIGIN RECOGNITION COMPLEX SUBUNIT 1; 1.
DR Pfam; PF00004; AAA; 1.
DR Pfam; PF17872; AAA_lid_10; 1.
DR Pfam; PF01426; BAH; 1.
DR Pfam; PF09079; Cdc6_C; 1.
DR SMART; SM00382; AAA; 1.
DR SMART; SM00439; BAH; 1.
DR SMART; SM01074; Cdc6_C; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51038; BAH; 1.
PE 3: Inferred from homology;
KW ATP-binding {ECO:0000256|RuleBase:RU365058};
KW DNA replication {ECO:0000256|ARBA:ARBA00022705,
KW ECO:0000256|RuleBase:RU365058};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125, ECO:0000256|RuleBase:RU365058};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842};
KW Nucleotide-binding {ECO:0000256|RuleBase:RU365058};
KW Nucleus {ECO:0000256|RuleBase:RU365058};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648}.
FT DOMAIN 43..166
FT /note="BAH"
FT /evidence="ECO:0000259|PROSITE:PS51038"
FT REGION 394..479
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 426..452
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 856 AA; 96472 MW; 4BF55E36EFD4BC9F CRC64;
MNTRQKSKII YSWYGKPTSS DRKLRTLQYK GILIISERSR TETCIQLGEF ILVEGENADQ
PFVAQLLDLY EDGAQQKRAV VQWFSHFTEI PQNKRKLLKR EVFPGEVFFD QVSGYDTDIA
VETIIKSVVV TPLRLGEELP IKFENEKTFY VKQSWDGKCF KPLSPDIFSK LKAANKKGSG
IPNSSNSFIS SDLTSPLKQE TERVVRSATK PKNVELEIES KHSASKSSVA KERHSQRMAN
AIKTPTARKK LQLNSPTRSP KTRLLGCEVL ELLDDDCDTV APLELSATKR KVKFTGILGS
PPKVPRANDK SKSVFDTAEN WCSDTMQLSP YNKVKDCSEK PENLKRKDDN IPLTEDQQLS
IQSLVLTPRS RRMCAQKTSA RIAEQISILN ALNQEEDSLS SSDSSYSSSS EEEEDDDDVL
CTPEKETKSS RTFSTPKSSR RSSVQTPAKT LKKTPLPGTP KTPRNATPEI PRRNHAAQKP
ASILEEARLR LHVSAVPESL PCREEEFQDI YNFVESKLID GTGGCMYISG VPGTGKTATV
HEVIRSLQQA AENDDLPSFQ CVEINGMKLT DPHQAYVQIL ELLTGQKVTA THAAELLAKL
FSMPGPKRKT TVLIVDELDL LWTRKQNVMY NLFDWPTQKH SKLIILAIAN TMDLPERIMM
NRVASRLGLT RMSFQPYTFK QLQQIISSRL NSIKAFEEDA IQLVSRKVAA LSGDARRCLD
ICRRATEICE FASQKRTPEI VRMTHVTEAI DEMFSSPYIK AIRNASLHEQ IFLKAILAEF
RRAGVEEATV QQVYHQHVAL CRIEGMQSPT VSELMGICSR LGACRLLLVE SSNKYIHMRV
RLNISQDDVM YALKDE
//
