ID A0A1V4K2Y9_PATFA Unreviewed; 803 AA.
AC A0A1V4K2Y9;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 08-NOV-2023, entry version 22.
DE SubName: Full=Ras GTPase-activating protein 4 {ECO:0000313|EMBL:OPJ78733.1};
GN ORFNames=AV530_003505 {ECO:0000313|EMBL:OPJ78733.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ78733.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ78733.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ78733.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ78733.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ78733.1}.
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DR EMBL; LSYS01005108; OPJ78733.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4K2Y9; -.
DR STRING; 372326.A0A1V4K2Y9; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR CDD; cd05395; RasGAP_RASA4; 1.
DR Gene3D; 2.60.40.150; C2 domain; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR000008; C2_dom.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR039360; Ras_GTPase.
DR InterPro; IPR023152; RasGAP_CS.
DR InterPro; IPR001936; RasGAP_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR001562; Znf_Btk_motif.
DR PANTHER; PTHR10194:SF4; RAS GTPASE-ACTIVATING PROTEIN 4-RELATED; 1.
DR PANTHER; PTHR10194; RAS GTPASE-ACTIVATING PROTEINS; 1.
DR Pfam; PF00779; BTK; 1.
DR Pfam; PF00168; C2; 2.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00616; RasGAP; 1.
DR PRINTS; PR00360; C2DOMAIN.
DR SMART; SM00107; BTK; 1.
DR SMART; SM00239; C2; 2.
DR SMART; SM00233; PH; 1.
DR SMART; SM00323; RasGAP; 1.
DR SUPFAM; SSF49562; C2 domain (Calcium/lipid-binding domain, CaLB); 2.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS50004; C2; 2.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS00509; RAS_GTPASE_ACTIV_1; 1.
DR PROSITE; PS50018; RAS_GTPASE_ACTIV_2; 1.
DR PROSITE; PS51113; ZF_BTK; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00432}.
FT DOMAIN 1..105
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 116..233
FT /note="C2"
FT /evidence="ECO:0000259|PROSITE:PS50004"
FT DOMAIN 305..513
FT /note="Ras-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50018"
FT DOMAIN 568..675
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 803 AA; 89949 MW; CCEF84911D970415 CRC64;
MARRSALSIR IVEGRNLPAK DITGSSDPYC IVKIDDEAII RTTTVWKTLS PFWGEEYEVH
LQPTFHSVSI YVMDEDALSR DDVIGKVCIT RDMLVEHPEG YSGWVSLSEV DPDEEVQGEI
HLRVEVHGSQ GGRRLLRCTV LEARDLARKD RNGASDPFVR LRYNGKAQES AVVKKSCYPR
WNETFEFELA EPTEEKLCVE VWDWDLVGRN DFLGKVVFSV QGLEAAGQEE GWFRLRPDKS
KPREDEHRGS LGSLQLQVRL RDETVLPSPC YQPLVQLLCQ EVKLGRQDGQ VHLVTLLDET
ITAECRQEVA VNLVKLFLGQ GLVKEYLDLL FELELAKPCE PNTLFRSNSL ASKSMESFLK
VTGMPYLHAV LGPTITRVFE EKKYVELDPS KVEIKDVGCS GLHRVQTEGE VIEQGRQYLQ
SYLDELLDAI SRSAPACPPV IRAVFRQLFH RVGERFPQHQ HTKFVAITSF LCLRFFSPAI
MTPKLFHLRE THADARTSRT LLLLAKAVQL VGNMEPAAGR AKETWLAPLL PALQQGIALM
KDFITRLVGM EQEEKEEGEG QPPVPPTTVV KEGLLFVHKT RGKGPVLATA AKKLHFCLSG
DTLSFGKSPG AERSGAIALG DILAAEKVEE KSFGSAHVMQ VVYVDAGGQQ ETAYLQCKCV
NELNQWLSAL RKVCVNNPRV LRAYHPGVFR GDKWSCCHQR ERTGPGCDRT HHGVTLQEWS
DPLDPATEAQ RLFHHLLGLR GTLREKYWEL LEPEDAQNGP MGEGVPLPEG LSRLLGVLGD
LEQCHRLAQP PAPPAPALLQ LQT
//
