ID A0A1V4K6I1_PATFA Unreviewed; 1008 AA.
AC A0A1V4K6I1;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 22-FEB-2023, entry version 21.
DE SubName: Full=Rap guanine nucleotide exchange factor 4 isoform B {ECO:0000313|EMBL:OPJ80066.1};
GN Name=RAPGEF4 {ECO:0000313|EMBL:OPJ80066.1};
GN ORFNames=AV530_002464 {ECO:0000313|EMBL:OPJ80066.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ80066.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ80066.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ80066.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ80066.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ80066.1}.
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DR EMBL; LSYS01004331; OPJ80066.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4K6I1; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd00038; CAP_ED; 2.
DR CDD; cd04437; DEP_Epac; 1.
DR CDD; cd00155; RasGEF; 1.
DR CDD; cd06224; REM; 1.
DR Gene3D; 1.10.8.1240; -; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 2.
DR Gene3D; 1.10.840.10; Ras guanine-nucleotide exchange factors catalytic domain; 1.
DR Gene3D; 1.20.870.10; Son of sevenless (SoS) protein Chain: S domain 1; 1.
DR Gene3D; 1.10.10.10; Winged helix-like DNA-binding domain superfamily/Winged helix DNA-binding domain; 1.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR000591; DEP_dom.
DR InterPro; IPR008937; Ras-like_GEF.
DR InterPro; IPR000651; Ras-like_Gua-exchang_fac_N.
DR InterPro; IPR019804; Ras_G-nucl-exch_fac_CS.
DR InterPro; IPR023578; Ras_GEF_dom_sf.
DR InterPro; IPR001895; RASGEF_cat_dom.
DR InterPro; IPR036964; RASGEF_cat_dom_sf.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR InterPro; IPR029071; Ubiquitin-like_domsf.
DR InterPro; IPR036388; WH-like_DNA-bd_sf.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR PANTHER; PTHR23113; GUANINE NUCLEOTIDE EXCHANGE FACTOR; 1.
DR PANTHER; PTHR23113:SF175; RAP GUANINE NUCLEOTIDE EXCHANGE FACTOR 4; 1.
DR Pfam; PF00027; cNMP_binding; 2.
DR Pfam; PF00610; DEP; 1.
DR Pfam; PF00617; RasGEF; 1.
DR Pfam; PF00618; RasGEF_N; 1.
DR PRINTS; PR00103; CAMPKINASE.
DR SMART; SM00100; cNMP; 2.
DR SMART; SM00049; DEP; 1.
DR SMART; SM00147; RasGEF; 1.
DR SMART; SM00229; RasGEFN; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 2.
DR SUPFAM; SSF48366; Ras GEF; 1.
DR SUPFAM; SSF54236; Ubiquitin-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 2.
DR PROSITE; PS50186; DEP; 1.
DR PROSITE; PS00720; RASGEF; 1.
DR PROSITE; PS50009; RASGEF_CAT; 1.
DR PROSITE; PS50212; RASGEF_NTER; 1.
PE 4: Predicted;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658,
KW ECO:0000256|PROSITE-ProRule:PRU00168};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648}.
FT DOMAIN 43..146
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 213..288
FT /note="DEP"
FT /evidence="ECO:0000259|PROSITE:PS50186"
FT DOMAIN 353..454
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT DOMAIN 493..631
FT /note="N-terminal Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50212"
FT DOMAIN 769..1006
FT /note="Ras-GEF"
FT /evidence="ECO:0000259|PROSITE:PS50009"
SQ SEQUENCE 1008 AA; 115216 MW; 7B72CC202335FDBA CRC64;
MVAAHTSHSS SSGEWIACLD KRPLERSSED VDIIFTRLKE VKAFEKFHPN LLQQICLCGY
YENLEKGITL FRQGDIGTNW YAVLTGSLDV KVSDTSNHQD AVTICTLGVG TAFGESILDN
TPRHATIVTR EYSELLRIEQ KDFKALWEKY RQYMSGLLTP PYGVMETGSN NDRMPDKDSM
SSSALCQVSK NCNKVPSEKI LRAGKILRNT ILSRAPHMIR DRKYHLKTYR QCCVGTELVD
WMMQQSPCVH SRSQAVGMWQ VLLEEGVLNH VDQEHHFQDK YLFYRFLDDE HEDAPLPTEE
EKKECDEELQ DTMLFLSQIG PDAHMRMILR KPPGQRTVDD LEIIYEELLH IKALSHLSTT
VKRELAGVLI FESHPKAGTV LFNQGEEGTS WYIILKGSVN VVIYGKGVVC TLHEGDDFGK
LALVNDAPRA ASIVLREDNC HFLRVDKEDF NRILRDVEAN TVRLKEHDQD VLVLEKIPAG
NRISNQGNSQ PQHKYIVMSG TPEKILEHFL ETMRLEATLN EATDSVLNDF IMMHCVFMPN
SQLCPALMAH YHAQPSQGTE QEKMDYALNN KRRVIRLVLQ WAALYGDLLQ EDEAAMAFLE
EFYVSVSDDT RMIAALKEQL PELEKIVKQV SEEPKAPQKK HKVLLQLFNT SDDRAQKRQP
IRGSDEVLFK VYCIDQTYTT IRVPVSSSVK EVISAVADKL GSGEGLIIVK MSSGGEKVVL
KPHDVSVFTT LSVNGRLFAC PRDQFDSLAP LPEQEGPSAG TVGTFELMSS KDLAHQMTIY
DWELFNCVHE LELIYHTFGR HNFKKTTANL DLFLRRFNEL QFWVVTEICL CSQLSKRVQL
LKKYIKIAAH CKEYKNLNSF FAIIMGLSNV AVSRLSLTWE KLPSKFKKIY AEFESLMDPS
RNHRAYRLTV AKLDPPIIPF MPLLIKDMTF THEGNKTFTD NLVNFEKMRM IANTVRTVKF
CRSQSFNPDA ALTNKNHQDV RSYVRQLNVI DNQRTLSQMS HRLEPRRA
//
