ID A0A1V4K6K2_PATFA Unreviewed; 1728 AA.
AC A0A1V4K6K2;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 03-MAY-2023, entry version 17.
DE RecName: Full=E3 ubiquitin-protein ligase {ECO:0000256|RuleBase:RU366018};
DE EC=2.3.2.27 {ECO:0000256|RuleBase:RU366018};
GN Name=UBR3 {ECO:0000313|EMBL:OPJ80034.1};
GN ORFNames=AV530_002441 {ECO:0000313|EMBL:OPJ80034.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ80034.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ80034.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ80034.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ80034.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Ubiquitin ligase protein which is a component of the N-end
CC rule pathway. Recognizes and binds to proteins bearing specific N-
CC terminal residues that are destabilizing according to the N-end rule,
CC leading to their ubiquitination and subsequent degradation.
CC {ECO:0000256|RuleBase:RU366018}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900,
CC ECO:0000256|RuleBase:RU366018};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|RuleBase:RU366018}.
CC -!- SIMILARITY: Belongs to the UBR1 family. {ECO:0000256|ARBA:ARBA00009750,
CC ECO:0000256|RuleBase:RU366018}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ80034.1}.
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DR EMBL; LSYS01004331; OPJ80034.1; -; Genomic_DNA.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniRule.
DR GO; GO:0071596; P:ubiquitin-dependent protein catabolic process via the N-end rule pathway; IEA:UniProtKB-UniRule.
DR CDD; cd16483; RING-H2_UBR3; 1.
DR CDD; cd19673; UBR-box_UBR3; 1.
DR Gene3D; 2.10.110.30; -; 1.
DR InterPro; IPR044046; E3_ligase_UBR-like_C.
DR InterPro; IPR039164; UBR1-like.
DR InterPro; IPR001841; Znf_RING.
DR InterPro; IPR003126; Znf_UBR.
DR PANTHER; PTHR21497:SF39; E3 UBIQUITIN-PROTEIN LIGASE UBR3; 1.
DR PANTHER; PTHR21497; UBIQUITIN LIGASE E3 ALPHA-RELATED; 1.
DR Pfam; PF18995; PRT6_C; 1.
DR Pfam; PF02207; zf-UBR; 1.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SUPFAM; SSF57850; RING/U-box; 1.
DR PROSITE; PS50089; ZF_RING_2; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU366018};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU366018};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|RuleBase:RU366018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU366018};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00175}.
FT DOMAIN 1..48
FT /note="UBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51157"
FT DOMAIN 1168..1223
FT /note="RING-type"
FT /evidence="ECO:0000259|PROSITE:PS50089"
FT ZN_FING 1..48
FT /note="UBR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT REGION 194..221
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 867..888
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1023..1048
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1030..1048
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1728 AA; 195650 MW; F46EC5086147D36C CRC64;
MSLCAECFHQ GEHAGHDYNM FRSQAGGACD CGDSNVMREA GFCKRHRIKS NSNVPCVPKD
LLMMSELVLP QFIFSLIQHL REGYNEPALD LPSEKDLHKI LQVLEPHVSF LEDLTKMGGA
MRSVLTQVLT SQQFYKDLSS GVGENACAKK SHEKYLIALK GSGLAFPEDK IACGVQEEGA
GTSTLAVQGL AGATATSGQG DSSDEEDQDG SQGVGKRKRV KLSSTTKDQS IMDVLKHKCF
LEELLFWTIK YEFPQKMVTF LLNMLPDQDY KIAFTKTFVQ HYAFIMKTLK KSHESDTMSN
RIVHISVQLF SNEELARQVT EECQLLDIMV TVLLYMMESC LIKSELQDEE NSLHVVVNCG
EALLKNNTYW PLVSDFINIL SHQSVAKKFL EDHGLLVTWM NFVSFFQGMN LNKRELNEHV
EFESQTYYAA FAAELEACAQ PMWGLLSHCK VRETQEYTRN VVRYCLEALQ DWFDAINFVD
EPAPNQVTFH LPLHRYFAMF LSKAVKCQEL DLDTILPDQE MLMKLMIHPL QIQASLSEIH
SNMWVRNGLQ IKGQAMTYVQ SHFCNSMIDP DIYLLQVCAS RLDPDYFISS VFERFKVVDL
LTMASQHQNT VLDSEHERSM LEGALTFLVL LLSLRLHLGM TDDEILRAEM VAQLCMNDRT
HSSLLDLIPE NPNPKSGIIP GSLSFESVLS AVADFKAPVF EPGGSMQQGM YTPKAEVWDK
EFDPVMVILR TVYRRDVQSA MDRYTAFLKQ SGKFPGNPWP PYKKRTPLHP SYKGLIKLLH
CKTLHIVLFT LLYKILMDHQ NLSEHVLCMV LYLIELGLEN SPEQESDEEE SAGGQERCHD
SWFPGSNLVS NMRHFINYVR VRVPETAPEV KREPPASTSS DGLAASQNSG TAQVFSLVAE
RRKKFQEIIN RNTSEANQVV RPKTSMKWSA PGATPQLTTA ILEVKESILS LLIKLHHKLS
GKQNSYYPPW LDDVDVLIHP ESSRYCHGDG MTAVERILLK AALQSRLNKR IIEEICRKVT
PPVPPKKISS AEKKALDKEE RRQKARERQQ KLLAEFASRQ KSFMETAMDV ESPDADIAME
VATSEQHVSE AIYDCVICGQ SGPSTEDRPT GLVVLLQASS VLGQCRSSTE PKKLPTTEEE
QIYSWDTCAT LHDARLSTLQ RYFKDSSCLQ AVSIGWEGGV YVQTCGHTLH IDCHKSYMES
LRNDQVLQGF SVDKGEFTCP LCRQFANSVL PCYPGNNTER SLWQSHSNKC MQDLVQEVED
LQEQLGTFPS ETNLSKEMES VMKDIKSTTQ KKYTDYSKSP GSPDNDFLFM YSVARTNLEL
ELVHRGGNLC SGGASTAGKR SCLNQLFHVL AMHMRLYSID SAYNPWRKLT QLMQDKNSEL
VSEELPEVPV LYRDVSSLLL IQILTMPQPL HKEHFTCIIK VLFTLLYTQA LAAFSVKCSA
EERMAWKESG ALKKNTSSGE KSWEVLLGHV ISELSKGKIY EEQETEELTV VNPDSVECDL
QQFCLPFLRI TSLLQHHLFG GDLPSCQEDE EFTVLASCLG LLPSFQSAHQ FTSASCLDWP
VPAFDMISQW CSELVSFSDT HPDQVKMLLM QEPKWDLPRL LQLPENYNTI FQYYHRKTCT
VCTKVPKDPA VCLVCGTFVC LKGLCCKQQS YCECVLHSQN CGAGTGIFLL INASVIIIIR
GHRFCLWGSV YLDAHGEEDR DLRRGKPLYI CKERYKVLEQ QFLLDMRL
//
