ID A0A1V4K8K6_PATFA Unreviewed; 424 AA.
AC A0A1V4K8K6;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 13.
DE SubName: Full=Rho GTPase-activating protein 8 {ECO:0000313|EMBL:OPJ80715.1};
GN Name=ARHGAP8 {ECO:0000313|EMBL:OPJ80715.1};
GN ORFNames=AV530_010968 {ECO:0000313|EMBL:OPJ80715.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ80715.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ80715.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ80715.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ80715.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ80715.1}.
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DR EMBL; LSYS01004200; OPJ80715.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4K8K6; -.
DR STRING; 372326.A0A1V4K8K6; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd04404; RhoGAP-p50rhoGAP; 1.
DR CDD; cd00170; SEC14; 1.
DR Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR InterPro; IPR049592; ARHGAP1_RhoGAP.
DR InterPro; IPR001251; CRAL-TRIO_dom.
DR InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR PANTHER; PTHR45808; RHO GTPASE-ACTIVATING PROTEIN 68F; 1.
DR PANTHER; PTHR45808:SF4; RHO GTPASE-ACTIVATING PROTEIN 8; 1.
DR Pfam; PF13716; CRAL_TRIO_2; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00516; SEC14; 1.
DR SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR PROSITE; PS50191; CRAL_TRIO; 1.
DR PROSITE; PS50238; RHOGAP; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000190648}.
FT DOMAIN 45..200
FT /note="CRAL-TRIO"
FT /evidence="ECO:0000259|PROSITE:PS50191"
FT DOMAIN 227..413
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 1..41
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..19
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 424 AA; 49231 MW; 73F62CBF6C9C8D29 CRC64;
MSEIDYEKLA EIELQKDEAE DTQSEQEETN TSPPLEDPEL NINHPYYDVA RHGIIQLAGD
DNSGRKVITF SCCRMPPSHQ LNHARLLEYL KYTLDQYVEN DYTVVYFHYG LKSLNKPSLK
WLQTAYKEFD RKYKKNLKAL YVVHPTNFIK ILWNIFKPLI SHKFGKKITY LNYLSDLREH
LKYDQLNIPQ EVIRHDENLR RKQKGKLPPV IKVPPPRPPL PTQQFGVSLQ YIMDKNKGEL
IPPVMKETVS YLKRKGLQVE GLFRRSASIQ TIKDVQKLYN QGKSVNFDDY HDIHIPAVIL
KTFLRELPQP LLTFECYDHV LGITSVESSL RVTRCKQIVQ GLPEHNYVVL KYLICFLHMV
SQESIYNRMT ASSLACVFGL NLIWPSKGTA SLSALVPLNL FTELLIDFYT NIFNSRTVPG
EILP
//
