ID A0A1V4K8N7_PATFA Unreviewed; 486 AA.
AC A0A1V4K8N7;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 17.
DE SubName: Full=5'-nucleotidase domain-containing protein 2 {ECO:0000313|EMBL:OPJ80819.1};
GN Name=NT5DC2 {ECO:0000313|EMBL:OPJ80819.1};
GN ORFNames=AV530_004237 {ECO:0000313|EMBL:OPJ80819.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ80819.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ80819.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ80819.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ80819.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- COFACTOR:
CC Name=Mg(2+); Xref=ChEBI:CHEBI:18420;
CC Evidence={ECO:0000256|PIRSR:PIRSR017434-2};
CC Note=Binds 1 Mg(2+) ion per subunit. {ECO:0000256|PIRSR:PIRSR017434-2};
CC -!- SIMILARITY: Belongs to the 5'(3')-deoxyribonucleotidase family.
CC {ECO:0000256|ARBA:ARBA00009589}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ80819.1}.
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DR EMBL; LSYS01004144; OPJ80819.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4K8N7; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0016787; F:hydrolase activity; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR CDD; cd07522; HAD_cN-II; 1.
DR Gene3D; 3.40.50.1000; HAD superfamily/HAD-like; 1.
DR InterPro; IPR036412; HAD-like_sf.
DR InterPro; IPR008380; HAD-SF_hydro_IG_5-nucl.
DR InterPro; IPR023214; HAD_sf.
DR InterPro; IPR016695; Pur_nucleotidase.
DR NCBIfam; TIGR02244; HAD-IG-Ncltidse; 1.
DR PANTHER; PTHR12103; 5'-NUCLEOTIDASE DOMAIN-CONTAINING; 1.
DR PANTHER; PTHR12103:SF14; 5'-NUCLEOTIDASE DOMAIN-CONTAINING PROTEIN 2; 1.
DR Pfam; PF05761; 5_nucleotid; 1.
DR PIRSF; PIRSF017434; Purine_5'-nucleotidase; 1.
DR SUPFAM; SSF56784; HAD-like; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801};
KW Magnesium {ECO:0000256|ARBA:ARBA00022842, ECO:0000256|PIRSR:PIRSR017434-2};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|PIRSR:PIRSR017434-2};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648}.
FT ACT_SITE 39
FT /note="Nucleophile"
FT /evidence="ECO:0000256|PIRSR:PIRSR017434-1"
FT ACT_SITE 41
FT /note="Proton donor"
FT /evidence="ECO:0000256|PIRSR:PIRSR017434-1"
FT BINDING 39
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR017434-2"
FT BINDING 41
FT /ligand="GMP"
FT /ligand_id="ChEBI:CHEBI:58115"
FT /evidence="ECO:0000256|PIRSR:PIRSR017434-2"
FT BINDING 324
FT /ligand="Mg(2+)"
FT /ligand_id="ChEBI:CHEBI:18420"
FT /evidence="ECO:0000256|PIRSR:PIRSR017434-2"
SQ SEQUENCE 486 AA; 57227 MW; D5CFEBD177BA2507 CRC64;
MKKLVYDLLP PGVCSLLNPA TIYANNEISL GDIEIYGFDY DYTLAQYSNL LHSMIFNTAR
DILIEQFKYP EGLGKYDYIP GFAIRGLHYD VQKSLLMKID AFHYVQLGTA YRGLKPVPDE
EVIELYGGTQ HIPLYQMSDF YGKGPSLKQF MDIFSLPEMT LLSSVIDYFI THGIEFDQVH
LYKDISDAIR DVHVKGVMYK WIEKDLEQYI LHGDEIYAVL NRLVNHKKKL FLITNSPFSF
VDKGMKHMVG KNWRDLFDMV IVQADKPNFF TDRRKPFRKL DEDGSLQWDK INQLEKGKIY
KEGNLFDFLR LTGWRGSKVL YFGDHLYSDL ADLMLRHGWR TGAIVPELET EIRIINTEQY
MHSLTWQQAL TGLLERMQMY QDAESKQVLL EWMKERQEIR SLTKNLFNPQ FGSIFRTFHN
PTYFSRRLVR FSDIYMASIS CLLNYDVNFT FYPRRTPLQH EAPLWMDQLC TGCMKTPFLE
EMVHIR
//
