ID A0A1V4KB66_PATFA Unreviewed; 191 AA.
AC A0A1V4KB66;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 18.
DE RecName: Full=Mitochondrial genome maintenance exonuclease 1 {ECO:0000256|HAMAP-Rule:MF_03030};
DE EC=3.1.-.- {ECO:0000256|HAMAP-Rule:MF_03030};
GN Name=MGME1 {ECO:0000256|HAMAP-Rule:MF_03030,
GN ECO:0000313|EMBL:OPJ81634.1};
GN ORFNames=AV530_014636 {ECO:0000313|EMBL:OPJ81634.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ81634.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ81634.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ81634.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ81634.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Metal-dependent single-stranded DNA (ssDNA) exonuclease
CC involved in mitochondrial genome maintenance. Has preference for 5'-3'
CC exonuclease activity. Necessary for maintenance of proper 7S DNA
CC levels. Probably involved in mitochondrial DNA (mtDNA) repair.
CC {ECO:0000256|HAMAP-Rule:MF_03030}.
CC -!- SUBCELLULAR LOCATION: Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03030}.
CC -!- SIMILARITY: Belongs to the MGME1 family. {ECO:0000256|HAMAP-
CC Rule:MF_03030}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ81634.1}.
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DR EMBL; LSYS01003963; OPJ81634.1; -; Genomic_DNA.
DR AlphaFoldDB; A0A1V4KB66; -.
DR STRING; 372326.A0A1V4KB66; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0005739; C:mitochondrion; IEA:UniProtKB-SubCell.
DR GO; GO:0008297; F:single-stranded DNA exodeoxyribonuclease activity; IEA:UniProtKB-UniRule.
DR GO; GO:0043504; P:mitochondrial DNA repair; IEA:UniProtKB-UniRule.
DR Gene3D; 3.90.320.10; -; 1.
DR HAMAP; MF_03030; MGME1; 1.
DR InterPro; IPR011604; PDDEXK-like_dom_sf.
DR InterPro; IPR038726; PDDEXK_AddAB-type.
DR PANTHER; PTHR31340; MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1; 1.
DR PANTHER; PTHR31340:SF3; MITOCHONDRIAL GENOME MAINTENANCE EXONUCLEASE 1; 1.
DR Pfam; PF12705; PDDEXK_1; 1.
PE 3: Inferred from homology;
KW Exonuclease {ECO:0000256|HAMAP-Rule:MF_03030, ECO:0000313|EMBL:OPJ81634.1};
KW Hydrolase {ECO:0000256|HAMAP-Rule:MF_03030};
KW Mitochondrion {ECO:0000256|HAMAP-Rule:MF_03030};
KW Nuclease {ECO:0000256|HAMAP-Rule:MF_03030};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648}.
FT DOMAIN 34..155
FT /note="PD-(D/E)XK endonuclease-like"
FT /evidence="ECO:0000259|Pfam:PF12705"
FT ACT_SITE 97
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03030"
FT ACT_SITE 110
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03030"
FT ACT_SITE 112
FT /evidence="ECO:0000256|HAMAP-Rule:MF_03030"
SQ SEQUENCE 191 AA; 21845 MW; C439AA6884F09A96 CRC64;
MSPQQNFYLE RWKQKMILEL GKAGFDEYTK NLFLQGELFH AALESIFLSE ETAAKEQGKD
ISGYLSSVQH VLKDISEVKA LESAVQHETL QYLGLVDCVA KYRGQLCVID WKTSEKPKPS
LKNTFDNPLQ VAAYIGAINH DASYDFQVSC GLVVVAYKNG SPAHPHFMDP DLCSQYWNQW
LLRLEEYMDR N
//
