ID   A0A1V4KBL5_PATFA        Unreviewed;       621 AA.
AC   A0A1V4KBL5;
DT   07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT   07-JUN-2017, sequence version 1.
DT   24-JAN-2024, entry version 10.
DE   RecName: Full=Zinc transporter ZIP12 {ECO:0000256|ARBA:ARBA00040591};
DE   AltName: Full=Solute carrier family 39 member 12 {ECO:0000256|ARBA:ARBA00042541};
DE   AltName: Full=Zrt- and Irt-like protein 12 {ECO:0000256|ARBA:ARBA00042971};
GN   Name=SLC39A12 {ECO:0000313|EMBL:OPJ81753.1};
GN   ORFNames=AV530_014315 {ECO:0000313|EMBL:OPJ81753.1};
OS   Patagioenas fasciata monilis.
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC   Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX   NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ81753.1, ECO:0000313|Proteomes:UP000190648};
RN   [1] {ECO:0000313|EMBL:OPJ81753.1, ECO:0000313|Proteomes:UP000190648}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ81753.1};
RC   TISSUE=Blood {ECO:0000313|EMBL:OPJ81753.1};
RA   Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA   Shapiro B.;
RT   "Band-tailed pigeon sequencing and assembly.";
RL   Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC   -!- CATALYTIC ACTIVITY:
CC       Reaction=Zn(2+)(in) = Zn(2+)(out); Xref=Rhea:RHEA:29351,
CC         ChEBI:CHEBI:29105; Evidence={ECO:0000256|ARBA:ARBA00034634};
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC   -!- SIMILARITY: Belongs to the ZIP transporter (TC 2.A.5) family.
CC       {ECO:0000256|ARBA:ARBA00006939}.
CC   -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC       whole genome shotgun (WGS) entry which is preliminary data.
CC       {ECO:0000313|EMBL:OPJ81753.1}.
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DR   EMBL; LSYS01003958; OPJ81753.1; -; Genomic_DNA.
DR   AlphaFoldDB; A0A1V4KBL5; -.
DR   Proteomes; UP000190648; Unassembled WGS sequence.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0046873; F:metal ion transmembrane transporter activity; IEA:InterPro.
DR   InterPro; IPR003689; ZIP.
DR   InterPro; IPR049406; ZIP4_12_EF-hand.
DR   InterPro; IPR041137; ZIP4_N.
DR   PANTHER; PTHR12191; SOLUTE CARRIER FAMILY 39; 1.
DR   PANTHER; PTHR12191:SF4; ZINC TRANSPORTER ZIP12; 1.
DR   Pfam; PF21116; EF-hand_Zip; 1.
DR   Pfam; PF02535; Zip; 1.
DR   Pfam; PF18292; ZIP4_domain; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}.
FT   TRANSMEM        335..358
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        365..389
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        412..437
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        467..493
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        531..550
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        562..580
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        592..615
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          22..180
FT                   /note="Zinc transporter ZIP4 N-terminal"
FT                   /evidence="ECO:0000259|Pfam:PF18292"
FT   DOMAIN          188..314
FT                   /note="Zinc transporter ZIP4/12 EF-hand"
FT                   /evidence="ECO:0000259|Pfam:PF21116"
SQ   SEQUENCE   621 AA;  69816 MW;  B8B99A0BC5AB8870 CRC64;
     MEVLRVLSAD NNELHMNHSR ELVKMLLERA ECPQRIYGMQ EDCNLCLEPD ALLIVAGGDL
     EDHLSEEVFE RISLILLYYI LHHRDVCSSE LSLNNKDYKF YLQSMLSLRH DEDCYYFSRN
     ETEDILAAVR QHFKTSETQC VDVSTLEKNA DIMDRDGADE NTLPRLAALI ITLALQGVCM
     GKASLPSPEF FTKYIFNSLN STTELQVTEL EQLLNVLTVK KTCTVNGQFH SHKRRRYGMA
     IRDTGNRNIT VKEGHPKGDY LKGYFEDGER NTDWDQACFS ANELVKIFLK NSSSSISKDH
     FKQISPAIIQ QLLTCSCHLP DSKQTKLPPT TLEKYGYSTV AVLLITIGSM FGTTLILFNS
     CQEIYTLVLQ LFVGLAVGTL SGDALLHLIP QTLGLHKHEA QEVEHFYEGK EYIWKLLGII
     GGIHGFFLIE KCFFLLVTPR EQRSPEDCES AEVPPESKAI SKKSKKISLL AIMVLVGDSL
     HNFADGLVIG AAFSSSTETG VTTTIAILCH EIPHEMGDFA VLLSTGLPTK IAILMNFISA
     LTAFLGLYIG LSVSTDLCIQ NWIFTVTAGM FLYLSLAEML PEMTHIQTQR PWLMFLLQNL
     GLLLGWLCLL LLAIYEQKIK I
//