ID A0A1V4KD49_PATFA Unreviewed; 715 AA.
AC A0A1V4KD49;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 27-MAR-2024, entry version 21.
DE RecName: Full=Histone-arginine methyltransferase CARM1 {ECO:0000256|ARBA:ARBA00021804};
DE EC=2.1.1.319 {ECO:0000256|ARBA:ARBA00011925};
DE AltName: Full=Coactivator-associated arginine methyltransferase 1 {ECO:0000256|ARBA:ARBA00033236};
DE AltName: Full=Protein arginine N-methyltransferase 4 {ECO:0000256|ARBA:ARBA00030670};
GN ORFNames=AV530_010218 {ECO:0000313|EMBL:OPJ82283.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ82283.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ82283.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ82283.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ82283.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=L-arginyl-[protein] + 2 S-adenosyl-L-methionine = 2 H(+) +
CC N(omega),N(omega)-dimethyl-L-arginyl-[protein] + 2 S-adenosyl-L-
CC homocysteine; Xref=Rhea:RHEA:48096, Rhea:RHEA-COMP:10532, Rhea:RHEA-
CC COMP:11991, ChEBI:CHEBI:15378, ChEBI:CHEBI:29965, ChEBI:CHEBI:57856,
CC ChEBI:CHEBI:59789, ChEBI:CHEBI:61897; EC=2.1.1.319;
CC Evidence={ECO:0000256|ARBA:ARBA00001817};
CC -!- SUBCELLULAR LOCATION: Chromosome {ECO:0000256|ARBA:ARBA00004286}.
CC Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Nucleus
CC {ECO:0000256|ARBA:ARBA00004123}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ82283.1}.
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DR EMBL; LSYS01003709; OPJ82283.1; -; Genomic_DNA.
DR STRING; 372326.A0A1V4KD49; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0005694; C:chromosome; IEA:UniProtKB-SubCell.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0016274; F:protein-arginine N-methyltransferase activity; IEA:InterPro.
DR GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 2.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 2.
DR InterPro; IPR025799; Arg_MeTrfase.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR020989; Histone-Arg_MeTrfase_N.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR029063; SAM-dependent_MTases_sf.
DR PANTHER; PTHR11006:SF51; HISTONE-ARGININE METHYLTRANSFERASE CARM1; 1.
DR PANTHER; PTHR11006; PROTEIN ARGININE N-METHYLTRANSFERASE; 1.
DR Pfam; PF11531; CARM1; 1.
DR Pfam; PF01031; Dynamin_M; 2.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR PROSITE; PS51678; SAM_MT_PRMT; 1.
PE 4: Predicted;
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Methyltransferase {ECO:0000256|ARBA:ARBA00022603, ECO:0000256|PROSITE-
KW ProRule:PRU01015}; Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW ECO:0000256|PROSITE-ProRule:PRU01015};
KW Transferase {ECO:0000256|PROSITE-ProRule:PRU01015};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 330..353
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 164..188
FT /note="Histone-arginine methyltransferase CARM1 N-terminal"
FT /evidence="ECO:0000259|Pfam:PF11531"
FT DOMAIN 574..650
FT /note="Dynamin stalk"
FT /evidence="ECO:0000259|Pfam:PF01031"
FT DOMAIN 651..715
FT /note="Dynamin stalk"
FT /evidence="ECO:0000259|Pfam:PF01031"
SQ SEQUENCE 715 AA; 79623 MW; 1F22BCDD9C082F0E CRC64;
MHRAGAGALW GRPGAGLGGP RGTVWIWGPL GHIYPLRCGF GGLWGTFGDP WGTFGGSLSK
FTHLGADLVT PAEHLGQISV FRCSFGASVR HVGVRTHQPT PAPPPAAVQP ALIPDKERKR
RYPFCFFAGA GXXXXXXXXX XXXXXXXXXX XXXXXXXXXX XXXXXFCSFY NILKNCRGHN
TERSVFSERT EESSAVQYFQ FYGYLSQQQN MMQDYVRTGT YQRAILQNHS DFKDKIVLDR
FTGATFDLLV ADTAVRSVPA PPGRHEVRFT LDGAVTSRCY RCRYRHRDGS AWATSAPSAE
IAVTDLGDGG CDPPTAPAPT PDALRRDASW IVPVAVGAAA LVLLVLAVAA VAWRGGGGHH
GAGARKIYAV EASTMAQHAE VLVKSNNLTE RIVVVPGKVE EVALPEQVDI IISEPMGYML
FNERMLESYL HAKKYLKPSG NMFPTIGDVH LAPFTDEQLY MEQFTKANFW YQPSFHGVDL
SALRGAAVDE YFRQPVVYLH FRIEIPFKFH MLHSGLVHGL AFWFDVAFIG SIMTVWLSTA
PTEPLTHWYQ VRCLFQSPLF AKAGDTLSGT CLLVANKSQK DIDGKKDIRA ALAAERKFFL
SHPAYRHMAD RMGTPHLQKV LNQQLTNHIR ETLPSLRSKL QSQLLSLEKE QFGVDFEKRI
EGSGDQVDTL ELSGGARINR IFHERFPFEL VKMEFDEKDL RREISYAIKN IHGVR
//
