ID A0A1V4KEV2_PATFA Unreviewed; 1730 AA.
AC A0A1V4KEV2;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 24-JAN-2024, entry version 23.
DE RecName: Full=E3 ubiquitin-protein ligase {ECO:0000256|RuleBase:RU366018};
DE EC=2.3.2.27 {ECO:0000256|RuleBase:RU366018};
GN Name=UBR1 {ECO:0000313|EMBL:OPJ82999.1};
GN ORFNames=AV530_010441 {ECO:0000313|EMBL:OPJ82999.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ82999.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ82999.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ82999.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ82999.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- FUNCTION: Ubiquitin ligase protein which is a component of the N-end
CC rule pathway. Recognizes and binds to proteins bearing specific N-
CC terminal residues that are destabilizing according to the N-end rule,
CC leading to their ubiquitination and subsequent degradation.
CC {ECO:0000256|RuleBase:RU366018}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine +
CC [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-
CC cysteine + N(6)-ubiquitinyl-[acceptor protein]-L-lysine.;
CC EC=2.3.2.27; Evidence={ECO:0000256|ARBA:ARBA00000900,
CC ECO:0000256|RuleBase:RU366018};
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906, ECO:0000256|RuleBase:RU366018}.
CC -!- SIMILARITY: Belongs to the UBR1 family. {ECO:0000256|ARBA:ARBA00009750,
CC ECO:0000256|RuleBase:RU366018}.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ82999.1}.
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DR EMBL; LSYS01003385; OPJ82999.1; -; Genomic_DNA.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0061630; F:ubiquitin protein ligase activity; IEA:UniProtKB-UniRule.
DR GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-UniRule.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniRule.
DR GO; GO:0071596; P:ubiquitin-dependent protein catabolic process via the N-end rule pathway; IEA:UniProtKB-UniRule.
DR CDD; cd16685; RING-H2_UBR1; 1.
DR CDD; cd19678; UBR-box_UBR1; 1.
DR Gene3D; 2.10.110.30; -; 1.
DR Gene3D; 3.30.1390.10; -; 1.
DR Gene3D; 1.10.10.2670; E3 ubiquitin-protein ligase; 1.
DR InterPro; IPR003769; ClpS_core.
DR InterPro; IPR042065; E3_ELL-like.
DR InterPro; IPR044046; E3_ligase_UBR-like_C.
DR InterPro; IPR014719; Ribosomal_bL12_C/ClpS-like.
DR InterPro; IPR047507; UBR-box_UBR1.
DR InterPro; IPR039164; UBR1-like.
DR InterPro; IPR036390; WH_DNA-bd_sf.
DR InterPro; IPR003126; Znf_UBR.
DR PANTHER; PTHR21497:SF27; E3 UBIQUITIN-PROTEIN LIGASE UBR1; 1.
DR PANTHER; PTHR21497; UBIQUITIN LIGASE E3 ALPHA-RELATED; 1.
DR Pfam; PF02617; ClpS; 1.
DR Pfam; PF18995; PRT6_C; 1.
DR Pfam; PF02207; zf-UBR; 1.
DR SMART; SM00396; ZnF_UBR1; 1.
DR SUPFAM; SSF54736; ClpS-like; 1.
DR SUPFAM; SSF46785; Winged helix' DNA-binding domain; 1.
DR PROSITE; PS51157; ZF_UBR; 1.
PE 3: Inferred from homology;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723,
KW ECO:0000256|RuleBase:RU366018};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648};
KW Transferase {ECO:0000256|ARBA:ARBA00022679, ECO:0000256|RuleBase:RU366018};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786,
KW ECO:0000256|RuleBase:RU366018};
KW Zinc {ECO:0000256|ARBA:ARBA00022833, ECO:0000256|RuleBase:RU366018};
KW Zinc-finger {ECO:0000256|RuleBase:RU366018}.
FT DOMAIN 71..142
FT /note="UBR-type"
FT /evidence="ECO:0000259|PROSITE:PS51157"
FT ZN_FING 71..142
FT /note="UBR-type"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00508"
FT REGION 819..846
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 974..997
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 819..836
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1730 AA; 197502 MW; 6DF62C6CF8038693 CRC64;
MWCDERFNFQ ATFLQCLAKH VPNIYSAEMD PLVEKQEEMV QAAILYPLEC YLFGEDPDVF
LEKLQQSGTS QLCGKVFKGG ETTYSCRDCA VDPTCVLCMD CFQNSIHKNH RYKMHSSTGG
GFCDCGDTEA WKAGPLCTKH EPGASGSAKE NSGCQLKEEI MEHSRRVFPS VIKYIVDMLV
WEEEKELPPE LVISREKVDS YYCVLFNDEH HSYDHVIYSL QRALGCELGE AQLHTTAIDK
EGRRAVKAGH YASCQEVKEE IKRHSENVSQ RPLHVEVLHA DVMAHQKFAL RLGSWLNKLM
SYSSDFRQIF CQICLKEEAG SEKPCFISKL MLWDAKLHKG ARKVLHELIF SSFFMEMEYK
KLFAVEFVKY YKALQKEYIS DDHDRVLSVT ALSVQMFTVP TLARHLIEEQ NVITTITETL
LEVLPEYLDK NDKFNFQGYS QDKLNRVYAV IYDLRYVLVS KPTLWTDRLR VRFLEGFVSF
LRILTCMQGM EEIKRQIGQH IEVDPDWEAA IAIQMQLKNI LLMFQEWCAC DEELLLKAYS
ECHKAVIRCS TNGRSREKTV FHLCGHTLES RPYRVSADPV SIHLPLSRTL AGLHVRLSKT
GTISRLHEFV SPEEFQVELL VEYPLRCLVL VAQVVAEMWR RNGLSLISQV FYYQDVKCRE
EMYDKDIIML QIGASLMDPN QFLLLILQRY ELAEAFKKLK PTKDQDLIKQ YNVLIEEMLQ
ILIYVVGERY VPGVSNVTKE DVIMREIIHL LCIEPMAHSA ITKSLPENEN YETGLENVID
KVATFKKPGV SGHGVYELKD ECLKEFNMFF YHYTKTQHSK AEHTQKKRRK QENRDEALPP
PPPPDFSPAF SNVVRILNCD VMMHILRTIL QRAVELETHL WTEAMIQMVL HLLSLGLLEE
KQQLQKSPEE EVTFDFYHKA TRMGSSALNA VSVLTLLEKL KRVPQLEAQK DTVSWILQMF
DTVKRLREKS SLTTVAATSG SEATKVDEST QDKEKAERKR KAEAARLHRQ KIMAQMSALQ
RNFIETHKLL YENTLEAQGK EDAVMEEESI SSAIDYSRIS LGPKRGPSVA EKEVLTCILC
QEEQEVKLES AAMVLSACVQ KSTALTQNRS RILEHSGDTL DPLFMHPDLP CGTHAGSCGH
VMHAACWQKY FEAMQLNFRQ RLHVEQIFDL ENGEYLCPLC KSLCNTVIPI VPLQAQKINS
EDAEAVAQIL SLARWLEIII ARISGYSVKN AKGEKQNLPA FTNKGMGNSA LEFNSILSFG
VQSSAKYSNS IKEMLILFAT TVYRVGLKVA PNEADYRIPM MTWSTCAFTV QCIENLLEAE
GKPLFGSLQN RQHSGLKALV QFAAAQRTTS PQVLIQQHLI RLLGVLLPNF KVEDTPSLLE
VDMFHILVGV VLSFPSLYWE DAVDLQPSSI SSAYNHLYLF HLTTLAHITQ IVVSSATESP
SAQSYENSEE AHSAQAFCRE VCQYTSGCFS QDIPGWLVWD CVKKGIMPYL RCAALFFHYM
LGVSPPEDLL QVSEEGQFKA LCSYLSLPTN LFLLFQEYRD TVNPLLQRWC ADPMVLSCLK
GKSIAVRYPR KRNSLIELPE DYSCLLNQAS QFRCPRSSDD EQKHPVLCLF CGAMLCSQNT
CCQELVNGEE LGACTSHALQ CGAGVCMFLK IRECKVVLIE GKTRGCLYPA PYLDEYGETD
PGLKRGNPLH LCRERYRKLH LLWQQHCIIE EIARSQETNQ IFFGFNWQLL
//
