ID A0A1V4KFD3_PATFA Unreviewed; 2120 AA.
AC A0A1V4KFD3;
DT 07-JUN-2017, integrated into UniProtKB/TrEMBL.
DT 07-JUN-2017, sequence version 1.
DT 08-NOV-2023, entry version 18.
DE SubName: Full=Ral GTPase-activating protein subunit alpha-1 isoform A {ECO:0000313|EMBL:OPJ83176.1};
GN Name=RALGAPA1 {ECO:0000313|EMBL:OPJ83176.1};
GN ORFNames=AV530_010572 {ECO:0000313|EMBL:OPJ83176.1};
OS Patagioenas fasciata monilis.
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Archelosauria; Archosauria; Dinosauria; Saurischia; Theropoda;
OC Coelurosauria; Aves; Neognathae; Columbiformes; Columbidae; Patagioenas.
OX NCBI_TaxID=372326 {ECO:0000313|EMBL:OPJ83176.1, ECO:0000313|Proteomes:UP000190648};
RN [1] {ECO:0000313|EMBL:OPJ83176.1, ECO:0000313|Proteomes:UP000190648}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=BTP2013 {ECO:0000313|EMBL:OPJ83176.1};
RC TISSUE=Blood {ECO:0000313|EMBL:OPJ83176.1};
RA Soares A.E., Novak B.J., Rice E.S., O'Connell B., Chang D., Weber S.,
RA Shapiro B.;
RT "Band-tailed pigeon sequencing and assembly.";
RL Submitted (FEB-2016) to the EMBL/GenBank/DDBJ databases.
CC -!- CAUTION: The sequence shown here is derived from an EMBL/GenBank/DDBJ
CC whole genome shotgun (WGS) entry which is preliminary data.
CC {ECO:0000313|EMBL:OPJ83176.1}.
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DR EMBL; LSYS01003385; OPJ83176.1; -; Genomic_DNA.
DR Proteomes; UP000190648; Unassembled WGS sequence.
DR GO; GO:0005634; C:nucleus; IEA:InterPro.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0051056; P:regulation of small GTPase mediated signal transduction; IEA:InterPro.
DR Gene3D; 3.40.50.11210; Rap/Ran-GAP; 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR035974; Rap/Ran-GAP_sf.
DR InterPro; IPR000331; Rap/Ran_GAP_dom.
DR InterPro; IPR046859; RGPA/RALGAPB_N.
DR InterPro; IPR027107; Tuberin/Ral-act_asu.
DR PANTHER; PTHR10063:SF3; RAL GTPASE-ACTIVATING PROTEIN SUBUNIT ALPHA-1; 1.
DR PANTHER; PTHR10063; TUBERIN; 1.
DR Pfam; PF20412; RALGAPB_N; 1.
DR Pfam; PF02145; Rap_GAP; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF111347; Rap/Ran-GAP; 1.
DR PROSITE; PS50085; RAPGAP; 1.
PE 4: Predicted;
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000190648}.
FT DOMAIN 1841..2049
FT /note="Rap-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50085"
FT REGION 339..385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 462..489
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 690..746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 922..954
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 982..1001
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1012..1050
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 2083..2120
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 348..363
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 364..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 466..487
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 690..709
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 711..744
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 938..954
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 2091..2120
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2120 AA; 238774 MW; 2722FB5A36705A54 CRC64;
MFSKKPHGDV RKSTQKVLDT RKDPLTRLKH LRVLIENAES IDLKQFFDVH FSHIYYVFFE
NFVTIEVGLK QKGHKSQREE LDSILFIFEK ILQLLPERIH QRWQFHSIGL ILKKLLHTGN
SLKIRREGVR LFLLWLQALQ NNCSKEQLWM FSCLIPGFSS PQSEYGPRTL DNLINPPVNV
QETQVTIEEI TPLVPPQSGD KGQEDLTSYF LEALLKYIVI QVKSLEWKNK ENQEKGFSFL
FSNFKKYYLP SIFPNICKET SLYNPILDIP QMRPKPHYVM VKKDAETNEA IYCTKEPFIK
ARVIVIRWLV SFWLEPKPHT GPHIPGMEGE NVPKNIQRAA ASMASREDSK NDSSDKQDRN
AEPEQSHSNT STLTEREPSS SSLCSIDEEH LTDIEIVRKV FSSKRNNVNF LTEIFRQAFL
LPICEAAAMR KVVKVYQEWI QQEDKPLFMK EPEEIMQCTT VDCDENGDHN SSEKAKDREE
EKEMNSSHVR NSNWGRNGCY EDTLHKIYDI DTEEQNVRAG VQSVLQVFII NSSNIFFLEP
ANEIKALLDE HTDMCKRILN IYRHMVVQVT MDKKTWEQML LVLLRVTESV LKIPPQTFLQ
YQGRKNSTLA GRLAGPLFQT LIVAWIKANL NVYISRELWD DLLSVMSSLT YWEELATEWS
LTMETLTKVL ARNLYSLDLS DLPLDKLSEQ KQKKHKGKGA GHEFPKSSVD KSFSRGWSRD
QPGQAPMRQR SATTTGSPGT EKARSIVRQK TVAMRSRSIG ECALPSAYIR SAKSAPVLIH
TSKPFLPDIV LTPLSDELSD IDDAQILPRP PRVRHFSQSE DAPGEVFGAL NEEQPLPRSS
STSDILEPFA VERAKANRED MSQKLHHIDS DIGSSNTNVP DLMDEFIAER LRSGSALNVT
RRGSSPGSLE VPKDLPDILN KQNQMRPIDD PGVPSEWTSP ASAGSSDLIS SDSHSDSFSA
FQYDGRKFEN FSFGTEAGTP ASTDVDAISG QQQSAEEQEV ASLTTLHIDS ETSSLNQQPL
SAEAATITGS ESASPIQSAL GSRSQTPSPA TLHADHIEQK DLQLDEKLHH SVLQTPDDLE
TSEFPSECCS VMAGGTLTGW HADVATVMWR RMLGILGDVN SIMDPEIHAQ VFDYLCELWQ
NLAKIRDNLG ISTDNLTSPS PPVLIPPLRI LTPWLFKATM LTDKYKQGKL HAYKLICKTM
KRRQDVSPNK DFLTHFYNIM HCGLLHVDQD IVNTIIKHCS PQFFSLGLPG ATMLIMDFIV
AAGRVAASSF LNAPRVEAQV LLGSLVCFPN LYHELPALHP NIPDIAVSQF TDVKELIIKT
VLSSAREEPS GPARCVALCS LGIWICEELV HESHHPQIKE ALNVICVSLK FPNKTVAQVA
CSMLNMLIHY VHRLQVYQAD SPLRIIQILI ATITHLLPST EASSYEQDKR LVVSLLLCLL
DWIMALPLKT LLQPLHTTGA ENDKTERSVL NCIYKVLHGC VYGSQCFSNP KYFPLSLSDL
ACVDYDPFMH LESLKEPEPL HSPDSERSSK LQPVTEVKSH MQQGLISVAA RTVITHLVNH
LGHYPMSGGP AMLTSQVCEN NDNPYSESPE LSPELFEKPN LQFFVLNNTS LVSCIQIQAE
DDMPGGGLSA GLASANSNVR IIVRDLSGKY SWDSAILYGP SSLCGSSQQT SFALSLSQQD
KPEDALSSFE HVEDVSARDG ITLQVKKKFR DTVPTWDTIR DEEDALDELL QYLGVTSPEC
LQRTGVSLNI PAPQPVCISE KQENDVINAI LKQHTEEREF VEKHFNDLNM RAMEQDEPTS
QKPQSAFYYC RLLLSILGMN SWDKRRSFHL LKKNEKLLRE LRNLDSRQCR ETHKIAVFYV
AEGQEDKHSI LTNTGGSQAY EDFVAGLGWE VNLTNHCGFM GGLQKNKSTG LTTPYFATST
VEVMFHVSTR MPSDSDDSLT KKLRHLGNDE VHIVWSEHTR DYRRGIIPTE FGDVLIVIYP
MKNHMFSIQI MKKPEVPFFG PLFDGAIVNG KILPIMVRAT AINASRALKS LIPLYQNFYE
ERARYLQTIH LTTTCPQRQI IKYQFCLSEG FCPETQLGET PAAATAQVDG TDLASPMSPR
TSKSRMSMKL RRSSGSANKS
//
